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公开(公告)号：US11867698B2
公开(公告)日：2024-01-09
申请号：US17027391
申请日：2020-09-21
Applicant: Life Technologies Corporation
Inventor： Jeffrey Dzubay , Kyle Gee , Vladimir Martin , Aleksey Rukavishnikov , Daniel Beacham
IPC: G01N33/58 , G01N33/50 , G01N33/84 , C09B11/24 , C09B11/28 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C09K11/06 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B57/00 , C09B69/00 , G01N31/22 , G01N33/80
CPC classification number: G01N33/582 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/80 , G01N33/84 , G01N2333/245 , Y10T436/143333
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I:
wherein the variables are described throughout the application.-
公开(公告)号：US09939454B2
公开(公告)日：2018-04-10
申请号：US14937736
申请日：2015-11-10
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jeffrey Dzubay , Kyle Gee , Vladimir Martin , Aleksey Rukavishnikov , Daniel Beacham
IPC: G01N33/84 , G01N33/58 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/28 , C09B57/00 , C09B69/00 , G01N31/22 , C09B11/24 , G01N33/50 , G01N33/80 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C09K11/06 , C07F5/02
CPC classification number: G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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公开(公告)号：US08968997B2
公开(公告)日：2015-03-03
申请号：US13965566
申请日：2013-08-13
Applicant: Life Technologies Corporation
Inventor： Kyle Gee , Vladimir Martin
IPC: G01N21/75 , C07D401/04 , C07D413/04 , C07D417/04 , C07D263/56 , C07D263/57 , C07D471/06 , C07D491/16 , C09K11/06 , G01N33/58 , G01N33/84
CPC classification number: G01N21/75 , C07D263/56 , C07D263/57 , C07D401/04 , C07D413/04 , C07D417/04 , C07D471/06 , C07D491/16 , C09B57/00 , C09B57/02 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/1048 , C09K2211/1088 , G01N33/582 , G01N33/84
Abstract: Disclosed are benzoxazole-based compounds, kits, and methods of producing and using the described compounds in fluorescence-based detection of analytes (e.g., metal ions). Also disclosed are uses of benzoxazole-based compounds as ratiometric metal ion indicators.
Abstract translation: 公开了基于苯并恶唑的化合物，试剂盒以及在分析物（例如金属离子）的基于荧光的检测中制备和使用所述化合物的方法。 还公开了苯并恶唑类化合物作为比例金属离子指示剂的用途。
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公开(公告)号：US20210041465A1
公开(公告)日：2021-02-11
申请号：US17027391
申请日：2020-09-21
Applicant: Life Technologies Corporation
Inventor： Jeffrey DZUBAY , Kyle Gee , Vladimir Martin , Aleksey Rukavishnikov , Daniel Beacham
IPC: G01N33/84 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C09K11/06 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/28 , C09B57/00 , C09B69/00 , G01N31/22 , G01N33/50 , C09B11/24 , G01N33/58 , G01N33/80
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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Patent Agency Ranking
公开(公告)号：US20180238912A1
公开(公告)日：2018-08-23
申请号：US15899021
申请日：2018-02-19
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jeffrey DZUBAY , Kyle Gee , Vladimir Martin , Aleksey Rukavishnikov , Daniel Beacham
IPC: G01N33/84 , C09B11/24 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/28 , C09B57/00 , G01N31/22 , G01N33/50 , G01N33/58 , C09K11/06 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C07F5/02 , C09B69/00 , G01N33/80
CPC classification number: G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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公开(公告)号：US09372181B2
公开(公告)日：2016-06-21
申请号：US14307445
申请日：2014-06-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle Gee , Vladimir Martin
IPC: G01N23/00 , G01N33/20 , C07C229/18 , C07D221/14 , C07D265/38 , C07D311/82 , C09B5/60 , C09B5/62 , C09B11/06 , G01N33/84 , C07D209/14 , C07D311/90 , C07D413/04
CPC classification number: G01N33/84 , C07C229/18 , C07C311/44 , C07D209/14 , C07D221/14 , C07D265/38 , C07D311/82 , C07D311/90 , C07D413/04 , C07K14/195 , C07K14/43595 , C09B5/60 , C09B5/62 , C09B11/06 , C09B11/08 , C09B19/00 , C09B19/005 , C09B57/08 , C09K11/06 , C09K2211/1014 , G01N33/20 , G01N2458/00
Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.
Abstract translation: 本发明提供用于检测靶金属离子的荧光化合物，其中化合物表现出大于50nm的斯托克斯位移，并且可检测信号通过光诱导电子转移（PET）调节。 本发明化合物由三种功能元件组成，即离子感测部分（螯合部分），报道部分（荧光团或荧光蛋白）以及本发明化合物的感测和报道部分之间的间隔物或接头，其允许在结合金属时的PET 通过适当的波长离子和激发。
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公开(公告)号：US20140363824A1
公开(公告)日：2014-12-11
申请号：US14307445
申请日：2014-06-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle Gee , Vladimir Martin
IPC: G01N33/20
CPC classification number: G01N33/84 , C07C229/18 , C07C311/44 , C07D209/14 , C07D221/14 , C07D265/38 , C07D311/82 , C07D311/90 , C07D413/04 , C07K14/195 , C07K14/43595 , C09B5/60 , C09B5/62 , C09B11/06 , C09B11/08 , C09B19/00 , C09B19/005 , C09B57/08 , C09K11/06 , C09K2211/1014 , G01N33/20 , G01N2458/00
Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.
Abstract translation: 本发明提供用于检测靶金属离子的荧光化合物，其中化合物表现出大于50nm的斯托克斯位移，并且可检测信号通过光诱导电子转移（PET）调节。 本发明化合物由三种功能元件组成，即离子感测部分（螯合部分），报道部分（荧光团或荧光蛋白）以及本发明化合物的感测和报道部分之间的间隔物或接头，其允许在结合金属时的PET 通过适当的波长离子和激发。
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公开(公告)号：US09910051B2
公开(公告)日：2018-03-06
申请号：US14455550
申请日：2014-08-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Daniel Beacham , Jeffrey Dzubay , Kyle Gee , Vladimir Martin , Aleksey Rukavishnikov
IPC: G01N33/84 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/28 , C09B57/00 , C09B69/00 , G01N31/22 , C09B11/24 , G01N33/50 , G01N33/58 , G01N33/80 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07D209/14 , C09K11/06 , C07F5/02
CPC classification number: G01N33/84 , C07D209/14 , C07D311/82 , C07D311/90 , C07D405/12 , C07D413/04 , C07D491/22 , C07F5/02 , C07K1/13 , C09B7/00 , C09B11/12 , C09B11/24 , C09B11/28 , C09B57/00 , C09B69/00 , C09K11/06 , G01N31/22 , G01N33/5005 , G01N33/5058 , G01N33/5091 , G01N33/582 , G01N33/80 , G01N2333/245 , Y10T436/143333
Abstract: A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and monitoring intracellular processes. The pH sensitive fluorescent dyes of the present invention include compounds of Formula I: wherein the variables are described throughout the application.
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公开(公告)号：US09846168B2
公开(公告)日：2017-12-19
申请号：US15152346
申请日：2016-05-11
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle Gee , Vladimir Martin
IPC: G01N21/76 , G01N33/84 , C07C229/18 , C07D221/14 , C07D265/38 , C07D311/82 , C09B5/60 , C09B5/62 , C09B11/06 , C09K11/06 , C07D209/14 , C07D311/90 , G01N33/20 , C07C311/44 , C07K14/195 , C07K14/435 , C09B11/08 , C09B19/00 , C09B57/08 , C07D413/04
CPC classification number: G01N33/84 , C07C229/18 , C07C311/44 , C07D209/14 , C07D221/14 , C07D265/38 , C07D311/82 , C07D311/90 , C07D413/04 , C07K14/195 , C07K14/43595 , C09B5/60 , C09B5/62 , C09B11/06 , C09B11/08 , C09B19/00 , C09B19/005 , C09B57/08 , C09K11/06 , C09K2211/1014 , G01N33/20 , G01N2458/00
Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.
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