公开(公告)号：US20240342286A1

公开(公告)日：2024-10-17

申请号：US18669670

申请日：2024-05-21

申请人： ORTA DOGU TEKNIK UNIVERSITESI ,  KOC UNIVERSITESI

发明人： Gorkem GUNBAS ,  Safacan KOLEMEN ,  Osman KARAMAN ,  Gizem ATAKAN ,  Toghrul ALMAMMADOV

IPC分类号： A61K41/00 ,  C07F5/02 ,  C07F7/08

CPC分类号： A61K41/0057 ,  C07F5/022 ,  C07F7/0814

摘要： Near-infrared (NIR) absorbing photosensitizers for imaging and treatment of cancer in a photodynamic therapy (PDT) are provided. Specifically, the NIR photosensitizers are mitochondria targeted and water-soluble, and used as a cytotoxic drug in a photodynamic therapy of the cancer. The NIR photosensitizers are activated with wavelengths of light, wherein the light penetrates through a body not just a skin. Hence the NIR photosensitizers aim to transform PDT from being a specialized treatment to a generally applicable one. PDT is almost completely non-invasive compared to current treatment methods.

公开(公告)号：US12109269B2

公开(公告)日：2024-10-08

申请号：US18175956

申请日：2023-02-28

申请人： LOYOLA UNIVERSITY OF CHICAGO

发明人： Daniel Paul Becker ,  Marlon Ray Lutz, Jr.

IPC分类号： A61K41/00 ,  A61K47/54 ,  C07F7/08

CPC分类号： A61K41/0095 ,  A61K47/545 ,  C07F7/0814

摘要： Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.

公开(公告)号：US20240114782A1

公开(公告)日：2024-04-04

申请号：US18266832

申请日：2021-12-15

申请人： Merck Patent GmbH

发明人： Philipp STOESSEL

IPC分类号： H10K85/60 ,  C07D471/08 ,  C07D471/16 ,  C07D487/06 ,  C07D487/16 ,  C07D487/18 ,  C07D487/22 ,  C07D491/16 ,  C07D491/20 ,  C07D491/22 ,  C07D495/16 ,  C07D495/22 ,  C07D498/22 ,  C07F7/08 ,  C09K11/02 ,  C09K11/06 ,  H10K85/40

CPC分类号： H10K85/6572 ,  C07D471/08 ,  C07D471/16 ,  C07D487/06 ,  C07D487/16 ,  C07D487/18 ,  C07D487/22 ,  C07D491/16 ,  C07D491/20 ,  C07D491/22 ,  C07D495/16 ,  C07D495/22 ,  C07D498/22 ,  C07F7/0814 ,  C09K11/02 ,  C09K11/06 ,  H10K85/40 ,  H10K85/615 ,  H10K85/624 ,  H10K85/654 ,  H10K85/657 ,  H10K50/11

摘要： The present invention relates to aromatic compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.

公开(公告)号：US11932661B2

公开(公告)日：2024-03-19

申请号：US17204094

申请日：2021-03-17

申请人： SAMSUNG SDI CO., LTD.

发明人： Byungku Kim ,  Junmo Park ,  Min Seok Seo ,  Namheon Lee ,  Mijin Lee ,  Kipo Jang ,  Sung-Hyun Jung ,  Eunjeong Choi

IPC分类号： H01L51/00 ,  C07F7/08 ,  H10K85/40 ,  H10K85/60 ,  H10K50/16 ,  H10K50/17

CPC分类号： C07F7/0807 ,  C07F7/0814 ,  H10K85/40 ,  H10K85/636 ,  H10K85/654 ,  H10K85/6572 ,  H10K85/6574 ,  H10K85/6576 ,  H10K50/16 ,  H10K50/171

摘要： A composition for an organic photoelectronic device, an organic photoelectronic device, and a display device, the composition comprising a first compound represented by Chemical Formula 1, and a second compound represented by Chemical Formula 2:

公开(公告)号：US11802124B2

公开(公告)日：2023-10-31

申请号：US17056653

申请日：2019-07-09

申请人： LG CHEM, LTD.

发明人： Hongsik Yoon ,  Jin Joo Kim ,  Wanpyo Hong ,  Dong Hoon Lee ,  Min Woo Jung ,  Jungha Lee

IPC分类号： C07D409/14 ,  C07D409/04 ,  C07D409/10 ,  C07D417/14 ,  C07D491/048 ,  C07F7/08 ,  H10K85/40 ,  H10K85/60 ,  H10K50/16 ,  H10K50/18 ,  H10K50/15 ,  H10K50/17

CPC分类号： C07D409/14 ,  C07D409/04 ,  C07D409/10 ,  C07D417/14 ,  C07D491/048 ,  C07F7/0814 ,  H10K85/40 ,  H10K85/654 ,  H10K85/6572 ,  H10K85/6574 ,  H10K85/6576 ,  H10K50/156 ,  H10K50/16 ,  H10K50/171 ,  H10K50/18

摘要： A compound of Chemical Formula 1, and an organic light emitting device including the same.

公开(公告)号：US20230312616A1

公开(公告)日：2023-10-05

申请号：US17861567

申请日：2022-07-11

申请人： Vertex Pharmaceuticals Incorporated

发明人： Alexander Russell ABELA ,  Jeremy J. CLEMENS ,  Peter Diederik Jan GROOTENHUIS ,  Sara Sabina HADIDA RUAH ,  Yoshihiro ISHIHARA ,  Haripada KHATUYA ,  Jason McCARTNEY ,  Mark Thomas MILLER ,  Fabrice Jean Denis PIERRE ,  Joe Anh TRAN ,  Jinglan ZHOU

IPC分类号： C07F7/08 ,  C07F7/30

CPC分类号： C07F7/0816 ,  C07F7/30 ,  C07F7/083 ,  C07F7/0814

摘要： This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

公开(公告)号：US11738092B2

公开(公告)日：2023-08-29

申请号：US17112288

申请日：2020-12-04

申请人： Dantari, Inc.

发明人： Emily A. Wyent ,  Carl M. Blumenfeld ,  Robert J. Lamm

IPC分类号： A61K47/69 ,  C07D491/22 ,  A61K47/60 ,  C07F5/02 ,  C07F7/08 ,  A61K47/54

CPC分类号： A61K47/6929 ,  A61K47/549 ,  A61K47/60 ,  C07D491/22 ,  C07F5/025 ,  C07F7/0814

摘要： Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.

公开(公告)号：US20230189633A1

公开(公告)日：2023-06-15

申请号：US17901519

申请日：2022-09-01

申请人： Samsung Display Co., Ltd.

发明人： SEULONG KIM ,  HAJIN SONG ,  JIHWAN YOON ,  JINA HUR ,  JAEHOON HWANG

IPC分类号： H01L51/00 ,  C07F7/08 ,  C09K11/06

CPC分类号： H01L51/0094 ,  C07F7/0814 ,  C09K11/06 ,  C07F7/081 ,  H01L51/5064

摘要： A light emitting element that includes a first electrode, a first hole transport region on the first electrode, a first emission layer on the first hole transport region, a first electron transport region on the first emission layer, and a second electrode on the first electron transport region is provided. The first hole transport region includes a polycyclic compound represented by Formula 1 and a compound represented by Formula H-1:

公开(公告)号：US20180175304A1

公开(公告)日：2018-06-21

申请号：US15577558

申请日：2016-11-17

申请人： LG Chem, Ltd.

发明人： Yongbum Cha ,  Jin Joo Kim ,  Sung Kil Hong ,  Sang Duk Suh

IPC分类号： H01L51/00 ,  C09K11/06 ,  C07D491/20 ,  C07D495/20 ,  C07D471/10 ,  C07F9/6568

CPC分类号： H01L51/0071 ,  C07D471/06 ,  C07D471/10 ,  C07D491/20 ,  C07D495/20 ,  C07F7/0814 ,  C07F7/0816 ,  C07F9/6561 ,  C07F9/65685 ,  C09K11/06 ,  C09K2211/1018 ,  H01L51/0052 ,  H01L51/0054 ,  H01L51/0058 ,  H01L51/0059 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0067 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/0085 ,  H01L51/0094 ,  H01L51/50 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5056 ,  H01L51/5088 ,  H01L51/5096

摘要： The present specification provides a compound having a spiro structure and an organic light emitting device including the same.

公开(公告)号：US20180155271A1

公开(公告)日：2018-06-07

申请号：US15889295

申请日：2018-02-06

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： ROBERT H. GRUBBS ,  ALEXEY FEDOROV ,  ANTON TOUTOV ,  NICHOLAS A. SWISHER

IPC分类号： C07C209/28 ,  C07F7/08 ,  C07C321/26 ,  C07C319/06 ,  C07C211/48 ,  C07C209/62 ,  C07C39/15 ,  C07C37/50 ,  C07C37/055 ,  C07C15/24 ,  C07C15/18 ,  C07C15/16 ,  C07C15/14 ,  C07C15/06 ,  C07C15/04 ,  C07C15/02 ,  C07C1/22

CPC分类号： C07C209/28 ,  C07B2200/05 ,  C07C1/22 ,  C07C37/055 ,  C07C37/50 ,  C07C209/62 ,  C07C319/06 ,  C07F7/081 ,  C07F7/0814 ,  C07C39/15 ,  C07C15/06 ,  C07C15/16 ,  C07C15/18 ,  C07C15/14 ,  C07C15/04 ,  C07C15/02 ,  C07C15/24 ,  C07C211/48 ,  C07C321/26

摘要： The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.