-
公开(公告)号：US20160271105A1
公开(公告)日：2016-09-22
申请号：US15078800
申请日：2016-03-23
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Sara Sabina HADIDA-RUAH , Peter Diederik Jan GROOTENHUIS , Fredrick F. VAN GOOR , Jinglan ZHOU , Brian Richard BEAR , Mark Thomas MILLER , Jason McCARTNEY , Mehdi Michel Djamel NUMA , Xiaoqing YANG , Nitin NAIR
IPC: A61K31/404 , A61K9/28 , A61K31/4709 , A61K45/06
CPC classification number: A61K31/404 , A61K9/28 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/47 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N33/6893 , G01N2333/705 , G01N2800/382 , A61K2300/00
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
-
公开(公告)号：US20230312616A1
公开(公告)日：2023-10-05
申请号：US17861567
申请日：2022-07-11
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Alexander Russell ABELA , Jeremy J. CLEMENS , Peter Diederik Jan GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Jason McCARTNEY , Mark Thomas MILLER , Fabrice Jean Denis PIERRE , Joe Anh TRAN , Jinglan ZHOU
CPC classification number: C07F7/0816 , C07F7/30 , C07F7/083 , C07F7/0814
Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
-
公开(公告)号：US20210139514A1
公开(公告)日：2021-05-13
申请号：US17044993
申请日：2019-04-05
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Alexander Russell ABELA , Jeremy J. CLEMENS , Peter Diederik Jan GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Jason McCARTNEY , Mark Thomas MILLER , Fabrice Jean Denis PIERRE , Joe Anh TRAN , Jinglan ZHOU
Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
-
公开(公告)号：US20190076419A1
公开(公告)日：2019-03-14
申请号：US15949404
申请日：2018-04-10
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Sara Sabina HADIDA RUAH , Peter Diederik Jan GROOTENHUIS , Fredrick F. VAN GOOR , Jinglan ZHOU , Brian Richard BEAR , Mark Thomas MILLER , Jason McCARTNEY , Mehdi Michel Djamel NUMA
IPC: A61K31/47 , C07D209/08 , A61K31/405 , A61K31/41 , C07D487/04 , G01N33/50 , A61K31/4045 , A61K31/407 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D233/64 , C07D471/04 , C07D405/14 , C07D405/12 , A61K31/404
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
-
公开(公告)号：US20210032272A1
公开(公告)日：2021-02-04
申请号：US15733738
申请日：2019-04-12
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Alexander Russell ABELA , Jeremy J. CLEMENS , Peter Diederik Jan GROOTENHUIS , Sara Sabina HADIDA RUAH , Yoshihiro ISHIHARA , Haripada KHATUYA , Jason McCARTNEY , Mark Thomas MILLER , Fabrice Jean Denis PIERRE , Joe Anh TRAN , Jinglan ZHOU
Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.
-
Patent Agency Ranking
6.发明申请Pyrrolopyrazine-Spirocyclic piperidine amides as modulators of ion channels 有权吡咯并吡嗪 - 螺环哌啶酰胺作为离子通道的调节剂公开(公告)号：US20150174127A1
公开(公告)日：2015-06-25
申请号：US14578628
申请日：2014-12-22
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Sara Sabina HADIDA RUAH , Edward Adam KALLEL , Mark Thomas MILLER , Vijayalaksmi ARUMUGAM , Jason McCARTNEY , Corey ANDERSON , Peter Diederik Jan GROOTENHUIS , Licong JIANG
IPC: A61K31/499 , A61K31/506
CPC classification number: C07D471/20 , A61K31/499 , A61K31/506 , C07D519/00
Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的吡咯并吡嗪 - 螺环哌啶酰胺化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号：US20230127655A1
公开(公告)日：2023-04-27
申请号：US17692235
申请日：2022-03-11
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Sara Sabina HADIDA RUAH , Peter Diederik Jan GROOTENHUIS , Fredrick F. VAN GOOR , Jinglan ZHOU , Brian Richard BEAR , Mark Thomas MILLER , Jason McCARTNEY , Mehdi Michel Djamel NUMA
IPC: A61K31/47 , C07D487/04 , G01N33/50 , C07D209/08 , A61K31/405 , A61K31/407 , A61K31/4192 , A61K31/4045 , C07D471/04 , A61K31/4184 , A61K31/454 , A61K31/404 , A61K31/5377 , C07D233/64 , C07D403/12 , A61K45/06 , C07D405/12 , C07D405/14 , A61K31/41
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
-
公开(公告)号：US20230100634A1
公开(公告)日：2023-03-30
申请号：US17217323
申请日：2021-03-30
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Sara Sabina HADIDA RUAH , Peter Diederik Jan GROOTENHUIS , Fredrick F. VAN GOOR , Jinglan ZHOU , Brian Richard BEAR , Mark Thomas MILLER , Jason McCARTNEY , Mehdi Michel Djamel NUMA
IPC: A61K31/47 , C07D471/04 , C07D209/08 , C07D405/12 , C07D405/14 , C07D233/64 , C07D403/12 , A61K31/4045 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D487/04 , G01N33/50 , A61K31/405 , A61K31/404
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
-
公开(公告)号：US20170189389A1
公开(公告)日：2017-07-06
申请号：US15234877
申请日：2016-08-11
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Sara Sabina HADIDA-RUAH , Peter Diederik Jan GROOTENHUIS , Fredrick F. VAN GOOR , Jinglan ZHOU , Brian Richard BEAR , Mark Thomas MILLER , Jason McCARTNEY , Mehdi Michel Djamel NUMA , Xiaoqing YANG
IPC: A61K31/47 , A61K31/404
CPC classification number: A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
-
公开(公告)号：US20170145011A1
公开(公告)日：2017-05-25
申请号：US15369029
申请日：2016-12-05
Applicant: Vertex Pharmaceuticals Incorporated
Inventor： Sara Sabina HADIDA RUAH , Edward Adam KALLEL , Mark Thomas MILLER , Vijayalaksmi ARUMUGAM , Jason McCARTNEY , Corey ANDERSON , Peter Diederik Jan GROOTENHUIS , Licong JIANG
IPC: C07D471/20 , A61K31/499
CPC classification number: C07D471/20 , A61K31/499 , A61K31/506 , C07D519/00
Abstract: The invention relates to pyrrolopyrazine-spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.051 seconds)
