公开(公告)号：US20190192657A1

公开(公告)日：2019-06-27

申请号：US16099035

申请日：2017-05-03

Applicant: COSMOPHOS LTD ,  UNIVERSIDAD AUTÓNOMA DE MADRID ,  KØBENHAVNS UNIVERSITET ,  UNIVERSITY OF EASTERN FINLAND

Inventor： Panagiotis TROHOPOULOS ,  Jørn Bolstad CHRISTENSEN ,  Tomás TORRES-CEBADA ,  Seyed Moein MOGHIMI ,  Seppo Pasi Antero YLÄ-HERTTUALA ,  Mario FICKER ,  Linping WU ,  María MEDEL GONZÁLEZ ,  Petri Ilmari MÄKINEN

IPC: A61K41/00 ,  A61K49/00 ,  A61P35/00 ,  A61P9/10

CPC classification number: A61K41/0071 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0093 ,  A61P9/10 ,  A61P35/00

Abstract: There is disclosed a composition comprising self-assembled nano-particles, the nano-particles comprising dendrimers having a phthalocyanine covalently bound to the periphery thereof. The composition is useful in the therapy and/or diagnosis and/or therapy monitoring and/or theranostics of a lesion of a tissue.

公开(公告)号：US20180245129A1

公开(公告)日：2018-08-30

申请号：US15967216

申请日：2018-04-30

Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Inventor： Edward J. DELIKATNY ,  Anatoliy V. Popov ,  Gang Zheng ,  Theresa Mawn

IPC: C12Q1/61 ,  G01N33/574 ,  G01N33/542 ,  G01N33/50 ,  A61K49/00 ,  A61K41/00

CPC classification number: C12Q1/61 ,  A61K41/0071 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0036 ,  G01N33/5011 ,  G01N33/542 ,  G01N33/57484

Abstract: The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.

公开(公告)号：US20180184956A1

公开(公告)日：2018-07-05

申请号：US15830798

申请日：2017-12-04

Applicant: Profusa, Inc.

Inventor： Soya Gamsey ,  Natalie Wisniewski ,  Kristen Helton ,  William McMillan

IPC: A61B5/1455 ,  C07F15/00 ,  A61B5/145 ,  A61K49/00 ,  G01N33/497 ,  C12Q1/54 ,  C09K11/06 ,  A61B5/00

CPC classification number: A61B5/14552 ,  A61B5/0059 ,  A61B5/14532 ,  A61B2503/40 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0073 ,  C07F15/0066 ,  C09K11/06 ,  C09K2211/185 ,  C12Q1/54 ,  G01N33/497 ,  G01N2333/904

Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

公开(公告)号：US09827313B2

公开(公告)日：2017-11-28

申请号：US14670890

申请日：2015-03-27

Applicant: SNU R&DB FOUNDATION ,  Institute for Basic Science ,  The Catholic University of Korea Industry-Academic Cooperation Foundation

Inventor： Taeghwan Hyeon ,  Kun Na ,  Daishun Ling ,  Wooram Park ,  Sin-jung Park ,  Yang Lu ,  Kyoung Sub Kim ,  Michael J. Hackett ,  Byung Hyo Kim ,  Hyeona Yim ,  Yong Sun Jeon

IPC: A61K49/00 ,  A61K41/00 ,  A61K49/18

CPC classification number: A61K41/0071 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/1857

Abstract: The present invention relates to a nanoformulated self-assembled pharmaceutical composition for photodynamic therapy. More particularly, the present invention is directed to a self-assembled pharmaceutical composition for photodynamic therapy comprising a photosensitizer, a ligand A which is separated at a specific pH range, and a ligand B of which surface charge changes at a specific pH range and a method for manufacturing the same.

公开(公告)号：US09772286B2

公开(公告)日：2017-09-26

申请号：US13703829

申请日：2011-06-20

Applicant: Keiji Inoue ,  Taro Shuin ,  Mutsuo Furihata ,  Yoshihiko Hirao ,  Tohru Tanaka

Inventor： Keiji Inoue ,  Taro Shuin ,  Mutsuo Furihata ,  Yoshihiko Hirao ,  Tohru Tanaka

IPC: G01N21/64 ,  G01N33/574 ,  G01N33/58 ,  A61K49/00 ,  A61K41/00

CPC classification number: G01N21/6486 ,  A61K41/0061 ,  A61K49/0021 ,  A61K49/0036 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/57407 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/582

Abstract: It is to provide a method for detecting urothelial cancer simply and with high accuracy. It is a method for detecting urothelial cancer comprising administering 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these to a test subject, collecting urine from the test subject, and detecting the presence of fluorescence or amount of fluorescence in the collected urine.

公开(公告)号：US20170128591A1

公开(公告)日：2017-05-11

申请号：US15319607

申请日：2015-06-18

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Juan Chen ,  Gang Zheng ,  Liyang Cui

IPC: A61K9/16 ,  B82Y5/00 ,  A61K49/00 ,  A61K31/404 ,  A61K9/51 ,  A61K41/00

CPC classification number: B82Y5/00 ,  A61K9/1075 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/404 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/42 ,  A61K47/544 ,  A61K47/6907 ,  A61K49/0036 ,  Y10S977/773 ,  Y10S977/801 ,  Y10S977/906 ,  Y10S977/915

Abstract: There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35 nm in diameter or less.

公开(公告)号：US09642916B2

公开(公告)日：2017-05-09

申请号：US13803878

申请日：2013-03-14

Applicant: The Regents of the University of California

Inventor： Kit S. Lam ,  Yuanpei Li ,  Chong-Xian Pan ,  Tzu-yin Lin

IPC: A61K47/42 ,  A61K47/48 ,  A61K49/04 ,  B82Y5/00 ,  A61K31/704 ,  A61K41/00 ,  A61K49/00 ,  A61K51/08 ,  A61K51/12 ,  A61N5/06

CPC classification number: A61K47/60 ,  A61K31/704 ,  A61K41/0033 ,  A61K41/0052 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/62 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0002 ,  A61K49/0036 ,  A61K49/0082 ,  A61K49/0423 ,  A61K49/1809 ,  A61K51/1227 ,  A61N5/062 ,  B82Y5/00

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US09597405B2

公开(公告)日：2017-03-21

申请号：US14588584

申请日：2015-01-02

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  SAN JOSE STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Victor Yee-Way Lee ,  Robert D. Miller ,  Hector H. Nuno ,  Joseph Sly

IPC: A61K49/00 ,  A61K47/48 ,  A61K9/51 ,  G01N33/58 ,  A61K49/04 ,  A61K49/18 ,  B82Y5/00 ,  B01J13/02 ,  C09B67/02 ,  C09B67/08 ,  C09B67/00 ,  C09B47/00 ,  B82Y30/00

CPC classification number: A61K47/48176 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5192 ,  A61K47/58 ,  A61K47/6929 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0065 ,  A61K49/0093 ,  A61K49/0097 ,  A61K49/0423 ,  A61K49/1818 ,  B01J13/02 ,  B82Y5/00 ,  B82Y30/00 ,  C09B47/00 ,  C09B67/0005 ,  C09B67/0032 ,  C09B67/0097 ,  C09B68/444 ,  C09B68/446 ,  G01N33/587 ,  Y10T428/249953 ,  Y10T428/2993 ,  Y10T428/2998

Abstract: A nanoshell is disclosed, comprising a star polymer occlusion complex comprising i) an amphiphilic unimolecular star polymer having a crosslinked core covalently linked to 6 or more independent polymer arms, and ii) a cargo material occluded in the star polymer; and a shell comprising an inorganic material in contact with a peripheral surface of the star polymer occlusion complex.

公开(公告)号：US20170049891A1

公开(公告)日：2017-02-23

申请号：US15235362

申请日：2016-08-12

Applicant: Nanoco Technologies Ltd.

Inventor： Imad Naasani

IPC: A61K41/00 ,  A61K47/48 ,  A61M5/00 ,  G01N33/58 ,  A61B5/00 ,  A61K9/50 ,  A61K49/00

CPC classification number: A61K41/0061 ,  A61B5/0071 ,  A61K9/501 ,  A61K47/64 ,  A61K47/6923 ,  A61K49/0036 ,  A61K49/005 ,  A61K49/0067 ,  A61M5/007 ,  B82Y5/00 ,  B82Y15/00 ,  G01N33/587 ,  Y10S977/915 ,  Y10S977/927

Abstract: A 5-aminolevulinic acid conjugated quantum dot nanoparticle is useful for treating cancer by administering the 5-aminolevulinic acid conjugated quantum dot nanoparticle in photodynamic therapy as a precursor of both a fluorescence label and a photosensitizer.

Abstract translation: 5-氨基乙酰丙酸共轭量子点纳米颗粒可用作治疗癌症的方法，其作为荧光标记物和光敏剂的前体，在光动力学治疗中施用5-氨基乙酰丙酸共轭量子点纳米颗粒。

公开(公告)号：US20160176886A1

公开(公告)日：2016-06-23

申请号：US15054517

申请日：2016-02-26

Applicant: NORTH CAROLINA STATE UNIVERSITY

Inventor： JONATHAN S. LINDSEY ,  MICHAEL KRAYER

IPC: C07D487/22 ,  A61K41/00 ,  A61N5/06 ,  G01N33/58 ,  G01N15/14 ,  C09B47/00 ,  A61K49/00

CPC classification number: C07D487/22 ,  A61K41/0071 ,  A61K49/0036 ,  A61N5/062 ,  C09B47/00 ,  G01N15/1404 ,  G01N33/582

Abstract: Compound of Formula I: are described, along with compositions containing the same and methods of use thereof.

Abstract translation: 描述了式I化合物，以及含有其的组合物及其使用方法。