公开(公告)号：US11219692B2

公开(公告)日：2022-01-11

申请号：US16355123

申请日：2019-03-15

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Kit S. Lam ,  Yuanpei Li ,  Chong-Xian Pan

IPC分类号： A61K9/00 ,  A61K47/60 ,  A61K41/00 ,  A61K49/00 ,  A61K49/04 ,  B82Y5/00 ,  A61K49/18 ,  A61K51/12 ,  A61K47/62 ,  A61K47/69 ,  A61K31/704 ,  A61N5/06

摘要： The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US11135309B2

公开(公告)日：2021-10-05

申请号：US15752326

申请日：2016-08-15

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Kit S. Lam ,  Yuanpei Li ,  Kai Xiao ,  Caihong Feng

IPC分类号： A61K47/69 ,  A61K9/51 ,  A61K47/32 ,  C08F230/06 ,  A61K9/00 ,  A61K47/58 ,  A61K47/54 ,  A61K47/68 ,  A61K49/18 ,  A61P35/00 ,  A61K31/69

摘要： The present invention provides a nanoparticle including at least one poly(vinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.

公开(公告)号：US10588982B2

公开(公告)日：2020-03-17

申请号：US15727490

申请日：2017-10-06

申请人： The Regents of the University of California

发明人： Diana Lac ,  Chun Feng ,  Gaurav Bhardwaj ,  Siddarth Chandrasekaran ,  Kit S. Lam

IPC分类号： A61K47/65 ,  C07D495/04 ,  C07D403/12 ,  A61K47/68

摘要： Methods and compositions are described herein for covalently linking an antibody to a molecular payload. Compositions are described herein containing an antibody covalently linked to a molecular payload.

公开(公告)号：US09644038B2

公开(公告)日：2017-05-09

申请号：US13719785

申请日：2012-12-19

申请人： The Regents of the University of California ,  Lawrence Livermore National Security, LLC

发明人： Juntao Luo ,  Wei He ,  Kit S. Lam ,  Paul Henderson ,  Matthew Coleman ,  R. Holland Cheng ,  Li Xing

IPC分类号： C07K14/00 ,  C07K17/02 ,  C07K14/775

CPC分类号： C07K17/02 ,  C07K14/775

摘要： The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

公开(公告)号：US09642916B2

公开(公告)日：2017-05-09

申请号：US13803878

申请日：2013-03-14

申请人： The Regents of the University of California

发明人： Kit S. Lam ,  Yuanpei Li ,  Chong-Xian Pan ,  Tzu-yin Lin

IPC分类号： A61K47/42 ,  A61K47/48 ,  A61K49/04 ,  B82Y5/00 ,  A61K31/704 ,  A61K41/00 ,  A61K49/00 ,  A61K51/08 ,  A61K51/12 ,  A61N5/06

CPC分类号： A61K47/60 ,  A61K31/704 ,  A61K41/0033 ,  A61K41/0052 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/62 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0002 ,  A61K49/0036 ,  A61K49/0082 ,  A61K49/0423 ,  A61K49/1809 ,  A61K51/1227 ,  A61N5/062 ,  B82Y5/00

摘要： The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US20210401993A1

公开(公告)日：2021-12-30

申请号：US17142026

申请日：2021-01-05

申请人： The Regents of the University of California

发明人： Nancy E. Lane ,  Ruiwu Liu ,  Wei Yao ,  Kit S. Lam

IPC分类号： A61K47/54 ,  A61K9/00 ,  A61K31/663 ,  A61K35/28 ,  A61K9/08 ,  A61K47/64

摘要： The present invention provides methods of treating a subject having a primary inflammatory disease or disorder comprising administering to the subject a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, wherein the composition comprising the LLP2A-bisphosphonate conjugate enhances the delivery of mesenchymal stem cells to a site of inflammation. Methods of enhancing an anti-inflammatory or immunomodulatory property of mesenchymal stem cells, comprising administering to a subject in need thereof the mesenchymal stem cells and a composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug, are also provided.

公开(公告)号：US20170174722A1

公开(公告)日：2017-06-22

申请号：US15387380

申请日：2016-12-21

申请人： The Regents of the University of California

发明人： Kit S. Lam ,  Ruiwu Liu ,  Wei Yao ,  Nancy Lane

IPC分类号： C07K5/097

CPC分类号： C07K5/0821 ,  A61K31/00 ,  A61K31/66 ,  A61K31/661 ,  A61K31/663 ,  A61K35/28 ,  A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/10 ,  A61K47/548 ,  A61K47/64 ,  C07F9/02 ,  C07K5/0817 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1019 ,  C07K7/06

摘要： The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α4β1 integrin on mesenchymal stem cells and for the surface of bone.

公开(公告)号：US08895055B2

公开(公告)日：2014-11-25

申请号：US13719766

申请日：2012-12-19

申请人： The Regents of the University of California

发明人： Kit S. Lam ,  Juntao Luo ,  Joyce S. Lee

IPC分类号： A61K9/127 ,  A61K31/7048

CPC分类号： A61K9/1271 ,  A61K9/1275 ,  A61K31/7048

摘要： The present invention provides a nanodisc without a membrane scaffold protein. The nanodisc includes a telodendrimer and a lipid; the nanodisc does not include a membrane scaffold protein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Methods of making the nanodiscs are also provided.

摘要翻译： 本发明提供一种没有膜支架蛋白的纳米圆盘。 纳米圆盘包括一个teendendrimer和一个脂质; 纳米圆盘不包括膜支架蛋白。 teendendrimer具有通式PEG-L-D（R）n，其中D是树枝状聚合物; L是与树枝状聚合物的焦点基团连接的键或连接体; 每个PEG是聚（乙二醇）聚合物; 每个R是树枝状聚合物的末端基团，或末端基团与共价键合的疏水基团，亲水基团，两亲化合物或药物; 并且下标n是2至20的整数。还提供了制造纳米圆盘的方法。

公开(公告)号：US20130164369A1

公开(公告)日：2013-06-27

申请号：US13719766

申请日：2012-12-19

申请人： The Regents of the University of California

发明人： Kit S. Lam ,  Juntao Luo ,  Joyce S. Lee

IPC分类号： A61K9/127 ,  A61K31/7048

CPC分类号： A61K9/1271 ,  A61K9/1275 ,  A61K31/7048

摘要： The present invention provides a nanodisc without a membrane scaffold protein. The nanodisc includes a telodendrimer and a lipid; the nanodisc does not include a membrane scaffold protein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Methods of making the nanodiscs are also provided.

摘要翻译： 本发明提供一种没有膜支架蛋白的纳米圆盘。 纳米圆盘包括一个teendendrimer和一个脂质; 纳米圆盘不包括膜支架蛋白。 teendendrimer具有通式PEG-L-D（R）n，其中D是树枝状聚合物; L是与树枝状聚合物的焦点基团连接的键或连接体; 每个PEG是聚（乙二醇）聚合物; 每个R是树枝状聚合物的末端基团，或末端基团与共价键合的疏水基团，亲水基团，两亲化合物或药物; 并且下标n是2至20的整数。还提供了制造纳米圆盘的方法。

公开(公告)号：US11612663B2

公开(公告)日：2023-03-28

申请号：US17062300

申请日：2020-10-02

申请人： The Regents of the University of California ,  Purdue Research Foundation

发明人： Alyssa Panitch ,  Emily Michelle Misnick ,  Jenny B. Lin ,  Kit S. Lam ,  Ruiwu Liu ,  Dake Hao ,  Aijun Wang

IPC分类号： A61K38/00 ,  A61K47/61 ,  A61K47/64 ,  A61K47/60 ,  A61P9/00 ,  C07K7/06 ,  C07K7/08

摘要： The present disclosure provides pro-angiogenic proteoglycan mimetics that can provide a provisional, pro-angiogenic scaffold to support tissue regeneration while limiting systemic exposure to VEGF activity. These mimetics can protect a collagen matrix from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing. For example, the provided compounds can be delivered from the end of a catheter following balloon angioplasty to coat the collagen exposed areas, prevent platelet binding and thrombosis, support capture of EPCs from blood to facilitate reendothelialization, and reduce late-lumen loss (neointimal hyperplasia).