公开(公告)号：US20190112423A1

公开(公告)日：2019-04-18

申请号：US16131644

申请日：2018-09-14

Applicant: The Regents of the University of California

Inventor： Kit S. Lam ,  Yuanpei Li ,  Juntao Luo ,  Kai Xiao

IPC: C08G65/334 ,  A61K47/34 ,  A61K47/60 ,  A61K31/337 ,  C08L71/02 ,  C08G65/329 ,  C08G83/00 ,  A61K47/28 ,  A61K45/06 ,  A61K9/107

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US20140161719A1

公开(公告)日：2014-06-12

申请号：US13803878

申请日：2013-03-14

Applicant: The Regents of the University of California

Inventor： Kit S. Lam ,  Yuanpei Li ,  ChongXian Pan ,  Tzu-yin Lin

IPC: A61K47/42

CPC classification number: A61K47/60 ,  A61K31/704 ,  A61K41/0033 ,  A61K41/0052 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/62 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0002 ,  A61K49/0036 ,  A61K49/0082 ,  A61K49/0423 ,  A61K49/1809 ,  A61K51/1227 ,  A61N5/062 ,  B82Y5/00

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Abstract translation: 本发明提供了聚合形成以疏水核心和亲水外部为特征的纳米载体的两亲性的前体衍生物。 纳米载体核可以包括两亲官能团，例如胆酸或胆酸衍生物，并且外部可以包括支链或直链的聚（乙二醇）链段。 纳米载体如疏水性药物和其他材料可以通过非共价方式螯合在核心中，或者可以共价结合到四聚体上。 Teendendrimer结构可以被定制以改变负载特性，与诸如生物膜的材料的相互作用以及其它特征。

公开(公告)号：US11219692B2

公开(公告)日：2022-01-11

申请号：US16355123

申请日：2019-03-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Kit S. Lam ,  Yuanpei Li ,  Chong-Xian Pan

IPC: A61K9/00 ,  A61K47/60 ,  A61K41/00 ,  A61K49/00 ,  A61K49/04 ,  B82Y5/00 ,  A61K49/18 ,  A61K51/12 ,  A61K47/62 ,  A61K47/69 ,  A61K31/704 ,  A61N5/06

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US11135309B2

公开(公告)日：2021-10-05

申请号：US15752326

申请日：2016-08-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Kit S. Lam ,  Yuanpei Li ,  Kai Xiao ,  Caihong Feng

IPC: A61K47/69 ,  A61K9/51 ,  A61K47/32 ,  C08F230/06 ,  A61K9/00 ,  A61K47/58 ,  A61K47/54 ,  A61K47/68 ,  A61K49/18 ,  A61P35/00 ,  A61K31/69

Abstract: The present invention provides a nanoparticle including at least one poly(vinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.

公开(公告)号：US09642916B2

公开(公告)日：2017-05-09

申请号：US13803878

申请日：2013-03-14

Applicant: The Regents of the University of California

Inventor： Kit S. Lam ,  Yuanpei Li ,  Chong-Xian Pan ,  Tzu-yin Lin

IPC: A61K47/42 ,  A61K47/48 ,  A61K49/04 ,  B82Y5/00 ,  A61K31/704 ,  A61K41/00 ,  A61K49/00 ,  A61K51/08 ,  A61K51/12 ,  A61N5/06

CPC classification number: A61K47/60 ,  A61K31/704 ,  A61K41/0033 ,  A61K41/0052 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/62 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0002 ,  A61K49/0036 ,  A61K49/0082 ,  A61K49/0423 ,  A61K49/1809 ,  A61K51/1227 ,  A61N5/062 ,  B82Y5/00

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US11369688B2

公开(公告)日：2022-06-28

申请号：US16332950

申请日：2017-09-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Kit S. Lam ,  Yuanpei Li ,  Gaurav Bharadwaj

IPC: A61K47/64 ,  A61K47/61 ,  A61K47/60 ,  A61K9/51 ,  A61K47/54 ,  A61K31/192 ,  A61K31/404 ,  A61K31/407 ,  A61K31/421 ,  B82Y5/00

Abstract: Methods and compositions are provided for hybrid telodendrimers and nanocarriers containing such hybrid telodendrimers.

公开(公告)号：US10238750B2

公开(公告)日：2019-03-26

申请号：US14651860

申请日：2013-12-12

Applicant: The Regents of the University of California

Inventor： Kit Lam ,  Yuanpei Li ,  Chongxian Pan

IPC: A61K9/00 ,  A61K47/60 ,  A61K49/04 ,  B82Y5/00 ,  A61K31/704 ,  A61K41/00 ,  A61K49/00 ,  A61K47/69 ,  A61K49/18 ,  A61K51/12 ,  A61K47/62 ,  A61N5/06

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US11559585B2

公开(公告)日：2023-01-24

申请号：US16622722

申请日：2018-06-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Yuanpei Li ,  Xiangdong Xue ,  Yee Huang ,  Zhao Ma

IPC: A61K9/00 ,  A61K47/69 ,  A61K31/337 ,  A61K31/417 ,  A61K31/475 ,  A61K31/4965 ,  A61K31/704 ,  A61K41/00 ,  G01N23/02

Abstract: The present inventions provides drug-drug conjugates, drug-porphyrin conjugates, nanoparticles of the conjugates, as well as modified nanoparticles having PEGylated exteriors or encapsulated by red blood cell vesicles. The conjugates, nanoparticles and nanocarriers are useful for treating cancers and other diseases, as well as for imaging diseased tissue or organs.

公开(公告)号：US11192978B2

公开(公告)日：2021-12-07

申请号：US16131644

申请日：2018-09-14

Applicant: The Regents of the University of California

Inventor： Kit S. Lam ,  Yuanpei Li ,  Juntao Luo ,  Kai Xiao

IPC: A61K47/60 ,  C08G83/00 ,  A61K47/28 ,  C08G65/334 ,  C08G65/329 ,  C08L71/02 ,  A61K9/107 ,  A61K45/06 ,  A61K47/34 ,  A61K31/337 ,  A61K9/127

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

公开(公告)号：US20160038605A1

公开(公告)日：2016-02-11

申请号：US14651860

申请日：2013-12-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Kit Lam ,  Yuanpei Li ,  Chongxian Pan

IPC: A61K47/48 ,  A61K51/12 ,  A61N5/06 ,  A61K41/00 ,  A61K49/00 ,  A61K31/704 ,  A61K51/08

CPC classification number: A61K47/60 ,  A61K31/704 ,  A61K41/0033 ,  A61K41/0052 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/62 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0002 ,  A61K49/0036 ,  A61K49/0082 ,  A61K49/0423 ,  A61K49/1809 ,  A61K51/1227 ,  A61N5/062 ,  B82Y5/00

Abstract: The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

Abstract translation: 本发明提供了聚合形成以疏水核心和亲水外部为特征的纳米载体的两亲性的前体衍生物。 纳米载体核可以包括两亲官能团，例如胆酸或胆酸衍生物，并且外部可以包括支链或直链的聚（乙二醇）链段。 纳米载体如疏水性药物和其他材料可以通过非共价方式螯合在核心中，或者可以共价结合到四聚体上。 Teendendrimer结构可以被定制以改变负载特性，与诸如生物膜的材料的相互作用以及其它特征。