- 专利标题: Porphyrin modified telodendrimers
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申请号: US13803878申请日: 2013-03-14
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公开(公告)号: US09642916B2公开(公告)日: 2017-05-09
- 发明人: Kit S. Lam , Yuanpei Li , Chong-Xian Pan , Tzu-yin Lin
- 申请人: The Regents of the University of California
- 申请人地址: US CA Oakland
- 专利权人: The Regents of the University of California
- 当前专利权人: The Regents of the University of California
- 当前专利权人地址: US CA Oakland
- 代理机构: Kilpatrick, Townsend & Stockton LLP
- 主分类号: A61K47/42
- IPC分类号: A61K47/42 ; A61K47/48 ; A61K49/04 ; B82Y5/00 ; A61K31/704 ; A61K41/00 ; A61K49/00 ; A61K51/08 ; A61K51/12 ; A61N5/06
摘要:
The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.
公开/授权文献
- US20140161719A1 PORPHYRIN MODIFIED TELODENDRIMERS 公开/授权日:2014-06-12
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