- 专利标题： LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT
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申请号： US15387380申请日： 2016-12-21
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公开(公告)号： US20170174722A1公开(公告)日： 2017-06-22
- 发明人: Kit S. Lam , Ruiwu Liu , Wei Yao , Nancy Lane
- 申请人： The Regents of the University of California
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 主分类号： C07K5/097
- IPC分类号： C07K5/097
摘要：
The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α4β1 integrin on mesenchymal stem cells and for the surface of bone.
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