Invention Application
- Patent Title: LLP2A-BISPHOSPHONATE CONJUGATES FOR OSTEOPOROSIS TREATMENT
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Application No.: US15387380Application Date: 2016-12-21
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Publication No.: US20170174722A1Publication Date: 2017-06-22
- Inventor: Kit S. Lam , Ruiwu Liu , Wei Yao , Nancy Lane
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Main IPC: C07K5/097
- IPC: C07K5/097
Abstract:
The present invention provides compounds and pharmaceutical compositions of a peptidomimetic ligand, e.g. LLP2A, conjugated with a bisphosphonate drug, e.g. Alendronate. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the α4β1 integrin on mesenchymal stem cells and for the surface of bone.
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