公开(公告)号：US20170128591A1

公开(公告)日：2017-05-11

申请号：US15319607

申请日：2015-06-18

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Juan Chen ,  Gang Zheng ,  Liyang Cui

IPC: A61K9/16 ,  B82Y5/00 ,  A61K49/00 ,  A61K31/404 ,  A61K9/51 ,  A61K41/00

CPC classification number: B82Y5/00 ,  A61K9/1075 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/404 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/42 ,  A61K47/544 ,  A61K47/6907 ,  A61K49/0036 ,  Y10S977/773 ,  Y10S977/801 ,  Y10S977/906 ,  Y10S977/915

Abstract: There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35 nm in diameter or less.