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公开(公告)号：US20140363900A1
公开(公告)日：2014-12-11
申请号：US14363778
申请日：2012-12-05
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Jonathan Lovell , Elizabeth Huynh
CPC classification number: C12Q1/6806 , A61K41/0028 , B01J13/02 , C12N11/04 , C12N13/00 , C12N15/88 , C12P1/00 , G01N1/28 , Y10T436/143333
Abstract: There is provided herein vesicles comprising a bilayer comprising porphyrin-phospholipid conjugate, wherein the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipids, wherein the vesicle is 1-100 microns in diameter.
Abstract translation: 提供了包含包含卟啉 - 磷脂缀合物的双层的囊泡，其中卟啉 - 磷脂缀合物包含共价连接到脂质侧链上的卟啉，卟啉衍生物或卟啉类似物，优选在sn-1或sn-2位， 的一种磷脂，其中囊泡的直径为1-100微米。
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公开(公告)号：US20170128591A1
公开(公告)日：2017-05-11
申请号：US15319607
申请日：2015-06-18
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Juan Chen , Gang Zheng , Liyang Cui
CPC classification number: B82Y5/00 , A61K9/1075 , A61K9/5169 , A61K31/337 , A61K31/404 , A61K41/0071 , A61K41/0076 , A61K47/42 , A61K47/544 , A61K47/6907 , A61K49/0036 , Y10S977/773 , Y10S977/801 , Y10S977/906 , Y10S977/915
Abstract: There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35 nm in diameter or less.
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3.发明申请Porphyrin-Lipid Stabilized Nanoparticles for Surface Enhanced Raman Scattering Based Imaging 审中-公开卟啉 - 脂质稳定纳米粒子的表面增强拉曼散射成像公开(公告)号：US20150104815A1
公开(公告)日：2015-04-16
申请号：US14397097
申请日：2013-04-19
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Natalie Tam
IPC: G01N21/65 , G01N33/574 , G01N33/58
CPC classification number: G01N21/658 , G01N33/57423 , G01N33/587
Abstract: Herein are provided nano-particles comprising a nanocore of Raman-scattering material stabilized by a bilayer comprising a porphyrin-phospholipid conjugate, methods of making the same and their use in Surface Enhanced Raman Scattering.
Abstract translation: 本文提供包含由包含卟啉 - 磷脂缀合物的双层稳定的拉曼散射材料的纳米孔的纳米颗粒，其制备方法及其在表面增强拉曼散射中的用途。
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公开(公告)号：US20240408209A1
公开(公告)日：2024-12-12
申请号：US18736918
申请日：2024-06-07
Applicant: Queen's University at Kingston , University Health Network
Inventor： Kevin Stamplecoskie , Parimah Aminfar , Goonay Yousefalizadeh , Gang Zheng , Juan Chen
IPC: A61K41/00 , A61K33/242 , A61N5/06
Abstract: A gold nanocluster of the formula Au16(RGDC)14, wherein RGDC is arginine-glycine-aspartic acid-cysteine, and methods for synthesis, are described. The gold nanocluster effectively produces Type I ROS and functions as photosensitizer, and has utility in applications such as, but not limited to, biomedical applications and photocatalysis. The gold nanocluster may be useful in photodynamic therapy (PDT) in cells and tissues for treating diseases such as certain cancers.
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公开(公告)号：US10729792B2
公开(公告)日：2020-08-04
申请号：US15567294
申请日：2016-04-14
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Joseph Keca
IPC: C07D487/22 , A61K49/22 , C07F9/6561 , C07F9/10 , C12P17/18
Abstract: There is provided herein, a texaphyrin-phospholipid conjugate, wherein the texaphyrin-phospholipid conjugate comprises a texaphyrin, texaphyrin derivative or texaphyrin analog covalently attached to a lipid side chain of a phospholipid.
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Patent Agency Ranking
公开(公告)号：US20150359912A1
公开(公告)日：2015-12-17
申请号：US14764403
申请日：2014-01-28
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Elizabeth Huynh , Kenneth Ng , Mojdeh Shakiba , Robert Weersink , Brian Wilson
CPC classification number: A61K49/227 , A61K49/0036 , A61K49/0052 , A61K49/0084 , A61K49/221
Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.
Abstract translation: 本文提供了具有包含饱和第一磷脂和不超过约15摩尔％的与J-骨料形成染料共价缀合的第二磷脂的双层的纳米囊。
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公开(公告)号：US20140257100A1
公开(公告)日：2014-09-11
申请号：US14351354
申请日：2012-10-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Jonathan Lovell , Elizabeth Huynh
CPC classification number: A61B8/481 , A61B5/0095 , A61K9/14 , A61K47/22 , A61K47/24 , A61K49/048 , A61K49/223
Abstract: The present invention relates to a microbubble comprising a monolayer of porphyrin-phospholipid conjugate, said microbubble having encapsulated therein, and to the use of said microbubble in ultrasound imaging of a target area in a subject.
Abstract translation: 本发明涉及包含单层卟啉 - 磷脂缀合物的微泡，所述微泡封装在其中，以及所述微泡在受试者的靶区域的超声成像中的用途。
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公开(公告)号：US20210308286A1
公开(公告)日：2021-10-07
申请号：US17264220
申请日：2019-07-30
Applicant: The Johns Hopkins University , University Health Network
Inventor： Martin G. Pomper , Ronnie C. Mease , Ying Chen , Sangeeta Ray , Juan Chen , Marta Overchuk , Kara Harmatys , Gang Zheng
Abstract: Theranostic probes comprising a porphyrin-based photosensitizer, a D-peptide linker, and a urea-based PSMA-targeting ligand and methods of their use for treating and/or imaging PMSA-expressing tumors are disclosed.
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公开(公告)号：US20190307893A1
公开(公告)日：2019-10-10
申请号：US16086235
申请日：2017-03-10
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Kenneth Ng , Juan Chen , Misa Takada , Kara Harmatys
Abstract: The application relates to liposomal nanovesicles comprising porphyrin-lipid conjugates within the liposomal lipid bilayer. Said porphyrin-lipid conjugate comprise porphyrins that are modified with a —CH(R1)—O—R2 group and that chelate a metal ion. Such modifications of the porphyrin allow for ordered assembly in the lipid bilayer of the nanovesicles while resulting in a bathochromic shift in the wavelength of light absorbed by the porphyrin chromophore. These nanovesicles can be used for photothermal therapy, photodynamic therapy, photoacoustic imaging and fluorescence imaging. The application also teaches methods for preparing the porphyrin-lipid conjugates and the nanovesicles.
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公开(公告)号：US20170319719A1
公开(公告)日：2017-11-09
申请号：US15661125
申请日：2017-07-27
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Elizabeth Huynh , Kenneth Ng , Mojdeh Shakiba , Robert Weersink , Brian Wilson
CPC classification number: A61K49/227 , A61K49/0036 , A61K49/0052 , A61K49/0084 , A61K49/221
Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.
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