公开(公告)号：US11607454B2

公开(公告)日：2023-03-21

申请号：US16303400

申请日：2017-05-19

Applicant: UNIVERSITY HEALTH NETWORK ,  THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Brian Wilson ,  Christine Allen

IPC: A61K41/00 ,  A61N5/10

Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.

公开(公告)号：US20170319719A1

公开(公告)日：2017-11-09

申请号：US15661125

申请日：2017-07-27

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Gang Zheng ,  Elizabeth Huynh ,  Kenneth Ng ,  Mojdeh Shakiba ,  Robert Weersink ,  Brian Wilson

IPC: A61K49/22 ,  A61K49/00

CPC classification number: A61K49/227 ,  A61K49/0036 ,  A61K49/0052 ,  A61K49/0084 ,  A61K49/221

Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.

公开(公告)号：US20150359912A1

公开(公告)日：2015-12-17

申请号：US14764403

申请日：2014-01-28

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Gang Zheng ,  Elizabeth Huynh ,  Kenneth Ng ,  Mojdeh Shakiba ,  Robert Weersink ,  Brian Wilson

IPC: A61K49/22 ,  A61K49/00

CPC classification number: A61K49/227 ,  A61K49/0036 ,  A61K49/0052 ,  A61K49/0084 ,  A61K49/221

Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.

Abstract translation: 本文提供了具有包含饱和第一磷脂和不超过约15摩尔％的与J-骨料形成染料共价缀合的第二磷脂的双层的纳米囊。