公开(公告)号：US20170128591A1

公开(公告)日：2017-05-11

申请号：US15319607

申请日：2015-06-18

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Juan Chen ,  Gang Zheng ,  Liyang Cui

IPC: A61K9/16 ,  B82Y5/00 ,  A61K49/00 ,  A61K31/404 ,  A61K9/51 ,  A61K41/00

CPC classification number: B82Y5/00 ,  A61K9/1075 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/404 ,  A61K41/0071 ,  A61K41/0076 ,  A61K47/42 ,  A61K47/544 ,  A61K47/6907 ,  A61K49/0036 ,  Y10S977/773 ,  Y10S977/801 ,  Y10S977/906 ,  Y10S977/915

Abstract: There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35 nm in diameter or less.

公开(公告)号：US20240408209A1

公开(公告)日：2024-12-12

申请号：US18736918

申请日：2024-06-07

Applicant: Queen's University at Kingston ,  University Health Network

Inventor： Kevin Stamplecoskie ,  Parimah Aminfar ,  Goonay Yousefalizadeh ,  Gang Zheng ,  Juan Chen

IPC: A61K41/00 ,  A61K33/242 ,  A61N5/06

Abstract: A gold nanocluster of the formula Au16(RGDC)14, wherein RGDC is arginine-glycine-aspartic acid-cysteine, and methods for synthesis, are described. The gold nanocluster effectively produces Type I ROS and functions as photosensitizer, and has utility in applications such as, but not limited to, biomedical applications and photocatalysis. The gold nanocluster may be useful in photodynamic therapy (PDT) in cells and tissues for treating diseases such as certain cancers.

公开(公告)号：US20210308286A1

公开(公告)日：2021-10-07

申请号：US17264220

申请日：2019-07-30

Applicant: The Johns Hopkins University ,  University Health Network

Inventor： Martin G. Pomper ,  Ronnie C. Mease ,  Ying Chen ,  Sangeeta Ray ,  Juan Chen ,  Marta Overchuk ,  Kara Harmatys ,  Gang Zheng

IPC: A61K51/08 ,  A61K41/00 ,  A61P35/00 ,  A61K49/00 ,  A61K47/65

Abstract: Theranostic probes comprising a porphyrin-based photosensitizer, a D-peptide linker, and a urea-based PSMA-targeting ligand and methods of their use for treating and/or imaging PMSA-expressing tumors are disclosed.

公开(公告)号：US20190307893A1

公开(公告)日：2019-10-10

申请号：US16086235

申请日：2017-03-10

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Gang Zheng ,  Kenneth Ng ,  Juan Chen ,  Misa Takada ,  Kara Harmatys

IPC: A61K47/69 ,  A61K47/54 ,  A61K9/127 ,  C07K17/02 ,  A61K41/00

Abstract: The application relates to liposomal nanovesicles comprising porphyrin-lipid conjugates within the liposomal lipid bilayer. Said porphyrin-lipid conjugate comprise porphyrins that are modified with a —CH(R1)—O—R2 group and that chelate a metal ion. Such modifications of the porphyrin allow for ordered assembly in the lipid bilayer of the nanovesicles while resulting in a bathochromic shift in the wavelength of light absorbed by the porphyrin chromophore. These nanovesicles can be used for photothermal therapy, photodynamic therapy, photoacoustic imaging and fluorescence imaging. The application also teaches methods for preparing the porphyrin-lipid conjugates and the nanovesicles.