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    Method and system for directing a localized biological response to an implant
    1.
    发明授权
    Method and system for directing a localized biological response to an implant 有权

    公开(公告)号：US10583308B2

    公开(公告)日：2020-03-10

    申请号：US15376147

    申请日：2016-12-12

    Applicant: Profusa, Inc.

    Inventor： William A. McMillan ,  Natalie Wisniewski

    IPC: A61M35/00 ,  A61N5/06 ,  A61B5/145 ,  A61K9/70 ,  A61B5/1459 ,  A61M5/142 ,  A61M11/00 ,  A61M37/00 ,  A61K9/00 ,  A61N5/067

    Abstract: The invention provides methods for directing a localized biological response of a mammalian body to an implant disposed within the body. In one embodiment, a delivery system is positioned outside the body and adjacent to the implant within the body. The delivery system comprises a first tissue response modifier effective for directing a localized biological response of the body to the implant. The tissue response modifier is nonsurgically delivered from the delivery system into the body in a quantity effective to direct the localized biological response of the body to the implant. The invention also provides an implant system for long-term use comprising an implant and nonsurgical means for delivering a tissue response modifier through the epidermis of the body, the tissue response modifier effective for directing a localized biological response of the body to the implant.

    METHOD AND DEVICE FOR CORRECTING OPTICAL SIGNALS
    5.
    发明申请
    METHOD AND DEVICE FOR CORRECTING OPTICAL SIGNALS 审中-公开
    用于校正光信号的方法和装置

    公开(公告)号：US20140275869A1

    公开(公告)日：2014-09-18

    申请号：US14199497

    申请日：2014-03-06

    Applicant: Profusa, Inc.

    Inventor： Gregory J. Kintz ,  William McMillan ,  Natalie Wisniewski

    IPC: A61B5/1459

    CPC classification number: A61B5/1459 ,  A61B5/14532 ,  A61B5/7203

    Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

    Abstract translation: 光学装置用于监测植入在哺乳动物组织中的植入物（例如皮下）。 植入物接收来自光学装置的激发光并且发射由光学装置检测到的光，包括与分析物相关的光学信号。 由于水合，血液灌注和氧合的变化，组织的分散和吸收性质随时间而变化。 光学装置具有光源，滤光器和检测器的布置，以在激发波长范围内传输激发光并测量检测波长内的发射光。 监测组织中光的散射和吸收的变化，例如漫反射。 光源，滤光片和检测器也可用于监测组织中的自发荧光以校正自发荧光背景。

    Method and device for correcting optical signals
    6.
    发明授权
    Method and device for correcting optical signals 有权

    公开(公告)号：US12059254B2

    公开(公告)日：2024-08-13

    申请号：US17493451

    申请日：2021-10-04

    Applicant: Profusa, Inc.

    Inventor： Gregory J. Kintz ,  William McMillan ,  Natalie Wisniewski

    IPC: A61B5/1459 ,  A61B5/00 ,  A61B5/145

    CPC classification number: A61B5/1459 ,  A61B5/14532 ,  A61B5/7203

    Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

    Method and device for correcting optical signals
    8.
    发明授权
    Method and device for correcting optical signals 有权

    公开(公告)号：US11134871B2

    公开(公告)日：2021-10-05

    申请号：US16102070

    申请日：2018-08-13

    Applicant: Profusa, Inc.

    Inventor： Gregory J. Kintz ,  William A. McMillan ,  Natalie Wisniewski

    IPC: A61B5/00 ,  A61B5/1459 ,  A61B5/145

    Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

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