公开(公告)号：US11903702B2

公开(公告)日：2024-02-20

申请号：US17020071

申请日：2020-09-14

Applicant: Profusa, Inc.

Inventor： Mary K. Balaconis ,  Scott Nichols ,  Sierra Guidry ,  Yu Zhang ,  Ryan Schweller ,  Soya Gamsey ,  Jacob William Clary ,  Sulolit Pradhan ,  Natalie Wisniewski

IPC: A61B5/1455 ,  G01N33/58 ,  A61B5/1459 ,  C09K11/06 ,  A61K49/00 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/14556 ,  A61B5/1459 ,  A61B5/14552 ,  A61K49/001 ,  C09K11/06 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14542 ,  C09K2211/185 ,  G01N33/582 ,  G01N2333/904

Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.

公开(公告)号：US11534503B2

公开(公告)日：2022-12-27

申请号：US16235278

申请日：2018-12-28

Applicant: Profusa, Inc.

Inventor： Mary K. Balaconis ,  Scott Nichols

IPC: A61K49/00

Abstract: Oxidase-based sensors and methods of using the sensors are provided.

公开(公告)号：US10772546B2

公开(公告)日：2020-09-15

申请号：US16023906

申请日：2018-06-29

Applicant: Profusa, Inc.

Inventor： Mary K. Balaconis ,  Scott Nichols ,  Sierra Guidry ,  Yu Zhang ,  Ryan Schweller ,  Soya Gamsey ,  Jacob William Clary ,  Sulolit Pradhan ,  Natalie Wisniewski

IPC: A61B5/1455 ,  G01N33/58 ,  A61B5/1459 ,  A61B5/145 ,  A61B5/00

Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.