公开(公告)号：US20230371984A1

公开(公告)日：2023-11-23

申请号：US18319445

申请日：2023-05-17

Applicant: Washington University ,  The George Washington University

Inventor： Eric Leuthardt ,  Guy Genin ,  Peter Brunner ,  Robert Pless ,  Camilo Molina ,  Carl Hacker ,  Daniel Moran ,  Alicia Repka ,  Halle Lowe ,  Jacob Sandler

IPC: A61B17/58 ,  A61B34/20 ,  A61B90/00

CPC classification number: A61B17/58 ,  A61B34/20 ,  A61B90/39 ,  A61B2034/2055

Abstract: Among the various aspects of the present disclosure is the provision of devices, systems, and methods for tracking the positions and orientations of at least one bone screw implanted within a surgical site. The disclosed device includes an extension that includes an extension base configured to couple to the bone screw, a marker arm coupled at one end to the extension base in a hinged arrangement, and an optical marker attached to a free end of the marker arm opposite the hinged attachment. The optical marker includes a pair of lenticular arrays in a coplanar arrangement in which the major axes of the lenticular arrays are mutually perpendicular. Each lenticular array is configured to display different hues at different viewing angles. The disclosed method includes transforming a single image of a surgical site containing at least one bone screw and extension into the global positions of each bone screw based on the pixel positions and hues corresponding to the lenticular arrays of each optical marker.

公开(公告)号：US10813941B2

公开(公告)日：2020-10-27

申请号：US16071459

申请日：2017-01-23

Applicant: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION ,  WASHINGTON UNIVERSITY IN ST. LOUIS

Inventor： Cynthia Dowd ,  Audrey Odom ,  Rachel Edwards ,  Robert Brothers

IPC: A61K31/7056 ,  A61K45/06 ,  A61K31/122 ,  A61K31/137 ,  A61K31/357 ,  A61K31/366 ,  A61K31/437 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/65 ,  A61K31/49 ,  A61K31/683 ,  A61K31/519 ,  A61K31/155 ,  A61P33/06

Abstract: A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.

公开(公告)号：US12122799B2

公开(公告)日：2024-10-22

申请号：US17253841

申请日：2019-06-18

Applicant: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION ,  WASHINGTON UNIVERSITY

Inventor： Cynthia Dowd ,  Audrey Odom John ,  Rachel Edwards ,  Kenneth M. Heidel ,  Xu Wang ,  Rene Chofor

IPC: A61P31/04 ,  C07F9/40

CPC classification number: C07F9/4015 ,  A61P31/04 ,  C07F9/4009

Abstract: The present disclosure provides method of treating or preventing a microbial infection caused by a prokaryotic pathogen in a subject, the method comprising administering a compound of Formula (I) as set forth in the specification. In one embodiment, the prokaryotic pathogen belongs to the genus Staphylococcus.

公开(公告)号：US11098072B2

公开(公告)日：2021-08-24

申请号：US16627004

申请日：2018-06-27

Applicant: The George Washington University ,  Washington University in St. Louis ,  George Mason University ,  Saint Louis University

Inventor： Cynthia Dowd ,  Xu Wang ,  Robert Carl Brothers ,  Audrey Ragan Odom John ,  Rachel Edwards ,  Marvin Meyers ,  Stacy Arnett ,  Robin Couch ,  Kenneth Heidel

IPC: C07F9/38 ,  A61P33/06 ,  A61P31/06 ,  C07F9/40

Abstract: The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are α,β-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.

公开(公告)号：US20190030056A1

公开(公告)日：2019-01-31

申请号：US16071459

申请日：2017-01-23

Applicant: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORA ,  WASHINGTON UNIVERSITY IN ST. LOUIS

Inventor： Cynthia DOWD ,  Audrey ODOM ,  Rachel Edwards ,  Robert BROTHERS

IPC: A61K31/7056 ,  A61P33/06 ,  A61K31/122 ,  A61K31/137 ,  A61K31/357 ,  A61K31/366 ,  A61K31/437 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/65

CPC classification number: A61K31/7056 ,  A61K31/122 ,  A61K31/137 ,  A61K31/155 ,  A61K31/357 ,  A61K31/366 ,  A61K31/437 ,  A61K31/4706 ,  A61K31/49 ,  A61K31/496 ,  A61K31/519 ,  A61K31/65 ,  A61K31/683 ,  A61K45/06 ,  A61P33/06 ,  Y02A50/411 ,  A61K2300/00

Abstract: A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.

公开(公告)号：US20210261580A1

公开(公告)日：2021-08-26

申请号：US17253841

申请日：2019-06-18

Applicant: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFI1 ,  WASHINGTON UNIVERSITY

Inventor： CYNTHIA DOWD ,  AUDREY ODOM JOHN ,  RACHEL EDWARDS ,  KENNETH M. HEIDEL ,  XU WANG ,  RENE CHOFOR

IPC: C07F9/40 ,  A61P31/04

Abstract: The present disclosure provides method of treating or preventing a microbial infection caused by a prokaryotic pathogen in a subject, the method comprising administering a compound of Formula (I) as set forth in the specification. In one embodiment, the prokaryotic pathogen belongs to the genus Staphylococcus.

公开(公告)号：US12238268B2

公开(公告)日：2025-02-25

申请号：US18448547

申请日：2023-08-11

Applicant: Washington University

Inventor： Samuel Achilefu ,  Yang Liu ,  Viktor Gruev ,  Joseph P. Culver ,  Walter Akers ,  Adam Bauer

IPC: G09G5/00 ,  A61B34/00 ,  A61B90/00 ,  A61B90/30 ,  A61K49/00 ,  C07K7/06 ,  G02B27/01 ,  H04N13/344 ,  H04N25/76 ,  A61B1/00 ,  A61B1/06

Abstract: A goggle system is provided. The goggle system includes a computing device, a goggle device configured to be worn by a user and including a detector configured to simultaneously acquire image data of a subject in a first image mode and a second image mode, at least one eye assembly configured to display at least one of an image in the first image mode, an image in the second image mode, and a hybrid image including pixels of image data from the first image mode and pixels of image data from the second image mode, and a communications module configured to transmit acquired image data from the goggle device to the computing device.

公开(公告)号：US12235948B2

公开(公告)日：2025-02-25

申请号：US17755692

申请日：2020-11-06

Applicant: Washington University

Inventor： Shantanu Chakrabartty ,  Mustafizur Rahman

IPC: G06F21/44 ,  G06F21/42 ,  H04L9/30

Abstract: A one-time self-powered timer circuit whose state can be measured only once, after which the timer will desynchronize itself. In this manner, the timers can only be used for one-pad authentication. The security of the public-key distribution algorithms that will exploit the synchronization between billions of hardware-software timers, time reversibility of software timer and time irreversibility of hardware timers and one-time read-out to deliver classical and quantum-like benefits. System-on-chip and circuit implementation of the self-powered timer array, read-out, programming and initialization modules that implements the proposed public-key distribution algorithms.

公开(公告)号：US12227562B2

公开(公告)日：2025-02-18

申请号：US17544416

申请日：2021-12-07

Applicant: The Regents of the University of California ,  The George Washington University ,  Baker Heart and Diabetes Research Institute

Inventor： Yury Miller ,  Michael Bukrinsky ,  Dmitri Sviridov

IPC: C07K16/18 ,  A61P31/18 ,  B82Y5/00 ,  A61K39/00

Abstract: In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for preventing or slowing the spread of a viral infection, wherein optionally the viral infection is a coronavirus infection, optionally a COVID-19 infection or variant thereof, or a human immunodeficiency virus (HIV) infection, preventing or decreasing coronavirus or HIV-co-morbidities in an individual, or inhibiting, or slowing the rate of, coronavirus (optionally COVID-19) or HIV replication in vitro and in vivo.

公开(公告)号：US12226382B2

公开(公告)日：2025-02-18

申请号：US17395357

申请日：2021-08-05

Applicant: Washington University

Inventor： Marco Colonna ,  Tyler Ulland

IPC: A61K31/195 ,  A61P25/28 ,  C12Q1/6827 ,  C12Q1/6883

Abstract: Among the various aspects of the present disclosure is the provision of methods of treating a microglial dysfunction-associated diseases, disorder, and conditions. The present disclosure provides for a method for treating microglial dysfunction in a subject having a microglial dysfunction-associated neurodegenerative disease comprising administering to a subject a therapeutically effective amount of a microglial rescuing agent. The present disclosure also provides for a method of reversing neuronal damage in a subject having a microglial dysfunction-associated neurodegenerative disease, wherein the microglial dysfunction-associated neurodegenerative disease is characterized by a single nucleotide polymorphisms (SNPs) or mutation in Trem2 or ApoE affecting microglial functions.