公开(公告)号：US11667784B2

公开(公告)日：2023-06-06

申请号：US16043992

申请日：2018-07-24

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Theresa Reineke ,  Craig Van Bruggen

IPC分类号： C08L39/00 ,  A61K47/50 ,  A61K47/58 ,  A61K31/49 ,  A61K48/00 ,  C08F220/56 ,  C08L33/14 ,  C08L33/24 ,  A61K47/32 ,  A61K38/02 ,  C12N15/87

CPC分类号： C08L39/00 ,  A61K31/49 ,  A61K47/32 ,  A61K47/50 ,  A61K47/58 ,  A61K48/0041 ,  C08F220/56 ,  C08L33/14 ,  C08L33/24 ,  A61K38/02 ,  C08L2203/02 ,  C12N15/87 ,  C08F220/56 ,  C08F226/02

摘要： Copolymers polymerized from at least one or more cinchona alkaloid containing compounds; and an acrylamide containing monomer, an acrylate containing monomer, or combinations thereof. Method of forming a copolymer-genetic component complex that includes a genetic component and a copolymer where the copolymer includes one or more cinchona alkaloid containing compounds and an acrylamide containing monomer, an acrylate containing monomer, or combinations thereof. Methods of delivering a genetic component to a cell.

公开(公告)号：US20230144186A1

公开(公告)日：2023-05-11

申请号：US17996853

申请日：2021-04-21

申请人： The Trustees of the University of Pennsylvania

发明人： Noam Cohen ,  Robert J. Lee ,  Susan R. Weiss ,  Joel N. Maslow ,  Christine C. Roberts ,  Sara Cherry ,  Michael Kohanski ,  Nithin D. Adappa ,  James N. Palmer ,  Li Hui Tan

IPC分类号： A61K31/49 ,  G01N33/569 ,  A61K9/00 ,  A61P31/14

CPC分类号： A61K31/49 ,  G01N33/56983 ,  A61K9/0043 ,  A61P31/14 ,  G01N2333/165

摘要： The invention provides methods and compositions for assaying infectivity of viruses and potential treatments of such viruses in the upper respiratory tract using an air-liquid interface model with nasal epithelium cells; and treatment of viral infections of the upper respiratory tract by treating with bitter taste receptor agonists that stimulate NO production and/or antimicrobial protein production.

公开(公告)号：US20180327809A1

公开(公告)日：2018-11-15

申请号：US15839387

申请日：2017-12-12

申请人： Concert Pharmaceuticals, Inc.

发明人： Roger Tung

IPC分类号： C12Q1/28 ,  G01N33/493 ,  G01N33/49 ,  A61K31/49 ,  A61K31/195 ,  C07B59/00 ,  C07D471/08 ,  A61K31/485 ,  A61K31/4709 ,  C07D221/28

CPC分类号： C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/002 ,  C07D221/28 ,  C07D471/08 ,  G01N33/491 ,  G01N33/493

摘要： This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σi receptor agonist that also has NMDA antagonist activity.

公开(公告)号：US20180243289A1

公开(公告)日：2018-08-30

申请号：US15748804

申请日：2016-07-29

申请人： Concert Pharmaceuticals, Inc.

发明人： Roger D. Tung

IPC分类号： A61K31/485 ,  A61K31/49

CPC分类号： A61K31/485 ,  A61K31/49

摘要： This invention relates to methods of treating agitation comprising administering a morphinan compound or a pharmaceutically acceptable salt thereof. This invention also provides the use in methods of treating agitation and related disorders with such a morphinan compound in combination with quinidine, or pharmaceutically acceptable salt of either or both thereof.

公开(公告)号：US09968653B2

公开(公告)日：2018-05-15

申请号：US15414925

申请日：2017-01-25

申请人： Regeneron Pharmaceuticals, Inc. ,  University Health Network

发明人： Lisa Arleen Purcell Ngambo ,  Sarah J. Higgins ,  Kevin C. Kain

IPC分类号： A61K38/16 ,  A61K38/18 ,  A61K31/357 ,  C07K14/515

CPC分类号： A61K38/1891 ,  A61K31/357 ,  A61K31/365 ,  A61K31/49 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/1866 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K14/515 ,  C07K16/22 ,  C07K2319/30 ,  Y02A50/386 ,  Y02A50/412 ,  A61K2300/00

摘要： The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a modified angiopoietin molecule such as AngF1-Fc-F1.

公开(公告)号：US20160101083A1

公开(公告)日：2016-04-14

申请号：US14975118

申请日：2015-12-18

申请人： BioResponse, L.L.C.

发明人： Michael A. Zeligs

IPC分类号： A61K31/404 ,  A61K31/407 ,  A61K45/06

CPC分类号： C07D209/04 ,  A61K31/12 ,  A61K31/155 ,  A61K31/357 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4164 ,  A61K31/4706 ,  A61K31/49 ,  A61K31/59 ,  A61K33/24 ,  A61K36/00 ,  A61K36/06 ,  A61K36/258 ,  A61K36/886 ,  A61K36/8962 ,  A61K38/193 ,  A61K45/06 ,  C07D209/52 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/492 ,  A61K2300/00

摘要： The present invention includes methods and compositions for the treatment and prevention of protozoal parasitic infections utilizing Diindolylmethane-related indoles. Additive and synergistic interaction of Diindolylmethane-related indoles with other known anti-parasitic and pro-apoptotic agents is believed to permit more effective therapy and prevention of protozoal parasitic infections. The methods and compositions described provide new treatment of protozoal parasitic diseases of mammals and birds including malaria, leishmaniasis, trypanosomiasis, trichomoniasis, neosporosis and coccidiosis.

摘要翻译： 本发明包括用于治疗和预防利用二吲哚基甲烷相关吲哚的原生动物寄生虫感染的方法和组合物。 二吲哚甲烷相关吲哚与其他已知的抗寄生虫和促凋亡剂的添加和协同相互作用被认为允许更有效的治疗和预防原生动物寄生虫感染。 所述的方法和组合物提供了对哺乳动物和鸟类的原生动物寄生虫病的新的治疗，包括疟疾，利什曼病，锥虫病，毛滴虫病，新孢子虫病和球虫病。

公开(公告)号：US09301956B2

公开(公告)日：2016-04-05

申请号：US14430168

申请日：2014-03-04

申请人： ADAM MICKIEWICZ UNIVERSITY

发明人： Lech Celewicz ,  Karol Kacprzak ,  Piotr Ruszkowski

IPC分类号： A61K31/49

CPC分类号： A61K31/49

摘要： 9-O-propargyl ethers of cinchona alkaloids of general formula represented by formula 1 wherein respective ethers have the following absolute configuration at C-8 and C-9 atoms: (8R,9S)-cinchonine configuration or (8R,9R)-9-epicinchonine configuration are useful in treatments of at least one of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.

摘要翻译： 由式1表示的通式生物碱的9-O-炔丙基醚，其中相应的醚在C-8和C-9原子具有以下绝对构型：（8R，9S） - 嘧啶醌构型或（8R，9R）-9 至少一种乳腺癌，宫颈癌，肺癌和鼻咽癌的治疗有用。

公开(公告)号：US20160045566A1

公开(公告)日：2016-02-18

申请号：US14529677

申请日：2014-10-31

申请人： Regeneron Pharmaceuticals, Inc. ,  University Health Network

发明人： Lisa Arleen Purcell Ngambo ,  Sarah J. Higgins ,  Kevin C. Kain

IPC分类号： A61K38/18 ,  A61K31/357 ,  C07K14/515 ,  A61K45/06

CPC分类号： A61K38/1891 ,  A61K31/357 ,  A61K31/365 ,  A61K31/49 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/1866 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K14/515 ,  C07K16/22 ,  C07K2319/30 ,  Y02A50/386 ,  Y02A50/412 ,  A61K2300/00

摘要： The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a modified angiopoietin molecule such as AngF1-Fc-F1.

摘要翻译： 本发明提供了治疗，预防或降低脑疟疾严重程度的方法。 本发明的方法包括向有需要的受试者施用治疗有效量的包含修饰的血管生成素分子如AngF1-Fc-F1的药物组合物。

公开(公告)号：US09072711B2

公开(公告)日：2015-07-07

申请号：US14141694

申请日：2013-12-27

申请人： Concert Pharmaceuticals, Inc.

发明人： Roger Tung

IPC分类号： A61K31/4748 ,  A61K31/195 ,  C07B59/00 ,  A61K31/4709 ,  A61K31/485 ,  C07D221/28 ,  C07D471/08 ,  A61K31/49

CPC分类号： A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/002 ,  C07D221/28 ,  C07D471/08

摘要： This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.

摘要翻译： 本公开涉及新的吗啡喃化合物及其衍生物，其药学上可接受的盐，溶剂合物和水合物。 本公开还提供了包含本公开的化合物的组合物以及这些组合物在治疗通过施用也具有NMDA拮抗剂活性的1受体激动剂有益治疗的疾病和病症的方法中的用途。

公开(公告)号：US20140221286A1

公开(公告)日：2014-08-07

申请号：US14345893

申请日：2012-09-20

申请人： Gilead Sciences, Inc.

发明人： Luiz Belardinelli ,  Arvinder Dhalla

IPC分类号： A61K38/28 ,  A61K31/138 ,  A61K31/4458 ,  A61K31/4965 ,  A61K31/519 ,  A61K31/341 ,  A61K31/49 ,  A61K31/166 ,  A61K31/4402 ,  A61K31/4166 ,  A61K31/4453 ,  A61K31/5415 ,  A61K45/06 ,  A61K31/64 ,  A61K31/4015 ,  A61K31/451 ,  A61K31/192 ,  A61K31/4439 ,  A61K31/167

CPC分类号： A61K38/28 ,  A61K31/138 ,  A61K31/166 ,  A61K31/167 ,  A61K31/192 ,  A61K31/341 ,  A61K31/4015 ,  A61K31/4166 ,  A61K31/4196 ,  A61K31/4402 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/4458 ,  A61K31/451 ,  A61K31/49 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/519 ,  A61K31/5415 ,  A61K31/64 ,  A61K45/06 ,  A61K2300/00

摘要： It is discovered that sodium-channel blockers inhibit the secretion of glucagon from pancreatic alpha cells. The present disclosure, based on such discoveries, provides compositions and methods for the treatment of hyperglycemia and related diseases and conditions with Na-channel blockers.

摘要翻译： 发现钠通道阻断剂抑制胰高血糖素从胰腺α细胞分泌。 基于这些发现的本公开提供了用Na通道阻断剂治疗高血糖症和相关疾病和病症的组合物和方法。