- 专利标题： QUININE AND ITS USE TO GENERATE INNATE IMMUNE RESPONSE
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申请号： US17996853申请日： 2021-04-21
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公开(公告)号： US20230144186A1公开(公告)日： 2023-05-11
- 发明人: Noam Cohen , Robert J. Lee , Susan R. Weiss , Joel N. Maslow , Christine C. Roberts , Sara Cherry , Michael Kohanski , Nithin D. Adappa , James N. Palmer , Li Hui Tan
- 申请人： The Trustees of the University of Pennsylvania
- 申请人地址： US PA Philadelphia
- 专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人地址： US PA Philadelphia
- 国际申请： PCT/US2021/028463 2021.04.21
- 进入国家日期： 2022-10-21
- 主分类号： A61K31/49
- IPC分类号： A61K31/49 ; G01N33/569 ; A61K9/00 ; A61P31/14
摘要：
The invention provides methods and compositions for assaying infectivity of viruses and potential treatments of such viruses in the upper respiratory tract using an air-liquid interface model with nasal epithelium cells; and treatment of viral infections of the upper respiratory tract by treating with bitter taste receptor agonists that stimulate NO production and/or antimicrobial protein production.
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