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公开(公告)号：US11597917B2
公开(公告)日：2023-03-07
申请号：US16619883
申请日：2018-06-06
Applicant: THE MEDICAL COLLEGE OF WISCONSIN, INC. , UNIVERSITY HEALTH NETWORK , WASHINGTON UNIVERSITY IN ST. LOUIS
Inventor： Jeffrey A. Medin , John F. Dipersio , Murtaza S. Nagree
IPC: C12N9/04 , A61P43/00 , A61K9/00 , A61K35/28 , C12N5/0789 , C12N7/00 , C12N9/40 , C12N9/24 , C12N9/80 , C12N15/86
Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.
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公开(公告)号：US11085933B2
公开(公告)日：2021-08-10
申请号：US16593316
申请日：2019-10-04
Applicant: Washington University in St. Louis
Inventor： David H. Gutmann , Corina Anastasaki
IPC: G01N33/53 , G01N33/68 , C12Q1/6883
Abstract: The present disclosure is generally related to neurofibromatosis type 1. More particularly, disclosed herein are methods for detecting behavioral disorders, methods for detecting cognitive impairment, and methods for detecting brain neurofibromin-dependent dopaminergic signaling associated with neurofibromatosis type 1.
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公开(公告)号：US10467741B2
公开(公告)日：2019-11-05
申请号：US15054215
申请日：2016-02-26
Applicant: Washington University in St. Louis
Inventor： Hua Li , Sasa Mutic , Mark Anastasio
Abstract: A method for optimizing a CT simulation protocol for different size patients for contouring and segmentation of organs and tumors. The method scanning different size phantoms, cadavers, or patients with a CT scanning x-ray tube to create a set of images and to create data sets for each different size phantoms, cadavers, or patients and then calculating an image quality index (IQI) as a benchmark for contouring accuracy. Finding an optimal IQI that characterizes patients of different sizes and using the optimal IQI to determine the accuracy of the contouring and segmentation of A CT simulation protocol for a patient.
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公开(公告)号：US20180310869A1
公开(公告)日：2018-11-01
申请号：US15770127
申请日：2016-10-19
Applicant: Washington University in St. Louis
Inventor： Dmitriy Yablonskiy , Yue Zhao
CPC classification number: A61B5/4088 , A61B5/0042 , A61B5/055 , A61B5/14542 , G01R33/50 , G01R33/5601 , G01R33/5608 , G01R33/5616 , G01R33/56366
Abstract: Disclosed are systems, biomarkers, and methods for the diagnosis of Alzheimer's Disease.
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5.发明申请System and Method for the Validation and Quality Assurance of Computerized Contours of Human Anatomy 审中-公开人体解剖学电脑轮廓的验证和质量保证体系与方法
公开(公告)号：US20150297916A1
公开(公告)日：2015-10-22
申请号：US14700592
申请日：2015-04-30
Applicant: Washington University in St. Louis
Inventor： Hsin-Chen Chen , Sasa Mutic , Jun Tan , Michael Altman , James Kavanaugh , Hua Li
IPC: A61N5/10
CPC classification number: A61N5/1039 , G06T7/13 , G06T2207/10081 , G06T2207/10116 , G06T2207/20081 , G06T2207/30004
Abstract: A system and method for validating the accuracy of delineated contours in computerized imaging using statistical data for generating assessment criterion that define acceptable tolerances for delineated contours, with the statistical data being conditionally updated and/or refined between individual processes for validating delineated contours to thereby adjust the tolerances defined by the assessment criterion in the stored statistical data, such that the stored statistical data is more closely representative of a target population. In an alternative embodiment, a system and method for validating the accuracy of delineated contours in computerized imaging using machine learning for assessing delineated contours, with the machine learning training data being used to generate geometric attributes, and the geometric attributes used to construct intra- and interstructural geometric attribute distribution models to automatically detect contouring errors. The present invention may be used to facilitate, as one example, radiation therapy.
Abstract translation: 用于使用用于生成评估标准的统计数据来验证计算机化成像中的描绘轮廓的准确度的系统和方法，所述评估标准定义了描绘轮廓的可接受公差，其中统计数据在用于验证所描绘的轮廓之间的各个过程之间有条件地更新和/或改进以由此调整 在所存储的统计数据中由评估标准定义的公差，使得存储的统计数据更接近于目标群体的代表。 在替代实施例中，一种系统和方法，用于使用机器学习来评估计算机化学习中描绘的轮廓的准确性的系统和方法，其中机器学习训练数据用于生成几何属性，以及用于构建内部和内部 结构几何属性分布模型自动检测轮廓误差。 作为一个示例，本发明可以用于促进放射治疗。
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公开(公告)号：US20240116972A1
公开(公告)日：2024-04-11
申请号：US18510128
申请日：2023-11-15
Applicant: Southern Research Institute , Oregon Health & Science University , Washington University in St. Louis , Board of Regents, The University of Texas System
Inventor： Omar Moukha-Chafiq , Ashish Kumar Pathak , Shuklendu D. Karyakarte , Larry D. Bratton , Corinne E. Augelli-Szafran , Michael Diamond , Pei Yong Shi , Alec Jay Hirsch , Jessica Lee Smith , Daniel Streblow , Nicole Haese , Baoling Ying
Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US11858956B2
公开(公告)日：2024-01-02
申请号：US17554979
申请日：2021-12-17
Applicant: Southern Research Institute , Oregon Health & Science University , Washington University in St. Louis , Board of Regents, The University of Texas System
Inventor： Omar Moukha-Chafiq , Ashish Kumar Pathak , Shuklendu D. Karyakarte , Larry D. Bratton , Corinne E. Augelli-Szafran , Michael Diamond , Pei Yong Shi , Alec Jay Hirsch , Jessica Lee Smith , Daniel Streblow , Nicole Haese , Baoling Ying
Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20210000821A1
公开(公告)日：2021-01-07
申请号：US16979443
申请日：2019-03-15
Applicant: Washington University in St. Louis , New York University
Inventor： Jennifer A. Philips , Kathryn Moore , Pallavi Chandra , Mireille Ouimet
IPC: A61K31/495 , A61K31/336
Abstract: Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.
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公开(公告)号：US09980660B2
公开(公告)日：2018-05-29
申请号：US14990469
申请日：2016-01-07
Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS
Inventor： Yoram Rudy , Yong Wang
CPC classification number: A61B5/04085 , A61B5/04012 , A61B5/6805 , A61B6/503 , A61B6/5247 , A61B8/0883 , A61B8/5261 , A61B2018/00839
Abstract: A non-transitory computer readable medium stores instructions that, when executed by at least one processor, cause the at least one processor to perform a method that includes computing a transfer matrix representing a relative influence that each respective electrode location for measuring electrical potentials on a patient's body has on an estimation of electrical potentials for locations on a surface of interest prior to the measuring of electrical potentials at the respective electrode locations and receiving electrical potential measurements measured via a plurality of electrodes at respective electrode locations on the patient's body. The method also includes computing the estimation of electrical potentials for the locations on the surface of interest based at least in part on the received electrical potential measurements and the computed transfer matrix and generating image data representing the estimation of electrical potentials.
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公开(公告)号：US20180014971A1
公开(公告)日：2018-01-18
申请号：US15714518
申请日：2017-09-25
Inventor： Raimondo D'Ambrosio , Samuel R. Browd , John W. Miller , Jeffrey G. Ojemann , Clifford L. Eastman , Matthew Smyth , Steven M. Rothman , Jason Fender
CPC classification number: A61F7/12 , A61F2007/0002
Abstract: The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological abnormalities using a thermally conductive graft including a thermally conductive matrix disposed between two opposed surfaces.
