公开(公告)号：US20230371984A1

公开(公告)日：2023-11-23

申请号：US18319445

申请日：2023-05-17

申请人： Washington University ,  The George Washington University

发明人： Eric Leuthardt ,  Guy Genin ,  Peter Brunner ,  Robert Pless ,  Camilo Molina ,  Carl Hacker ,  Daniel Moran ,  Alicia Repka ,  Halle Lowe ,  Jacob Sandler

IPC分类号： A61B17/58 ,  A61B34/20 ,  A61B90/00

CPC分类号： A61B17/58 ,  A61B34/20 ,  A61B90/39 ,  A61B2034/2055

摘要： Among the various aspects of the present disclosure is the provision of devices, systems, and methods for tracking the positions and orientations of at least one bone screw implanted within a surgical site. The disclosed device includes an extension that includes an extension base configured to couple to the bone screw, a marker arm coupled at one end to the extension base in a hinged arrangement, and an optical marker attached to a free end of the marker arm opposite the hinged attachment. The optical marker includes a pair of lenticular arrays in a coplanar arrangement in which the major axes of the lenticular arrays are mutually perpendicular. Each lenticular array is configured to display different hues at different viewing angles. The disclosed method includes transforming a single image of a surgical site containing at least one bone screw and extension into the global positions of each bone screw based on the pixel positions and hues corresponding to the lenticular arrays of each optical marker.

公开(公告)号：US10813941B2

公开(公告)日：2020-10-27

申请号：US16071459

申请日：2017-01-23

申请人： THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION ,  WASHINGTON UNIVERSITY IN ST. LOUIS

发明人： Cynthia Dowd ,  Audrey Odom ,  Rachel Edwards ,  Robert Brothers

IPC分类号： A61K31/7056 ,  A61K45/06 ,  A61K31/122 ,  A61K31/137 ,  A61K31/357 ,  A61K31/366 ,  A61K31/437 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/65 ,  A61K31/49 ,  A61K31/683 ,  A61K31/519 ,  A61K31/155 ,  A61P33/06

摘要： A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.

公开(公告)号：US12122799B2

公开(公告)日：2024-10-22

申请号：US17253841

申请日：2019-06-18

申请人： THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION ,  WASHINGTON UNIVERSITY

发明人： Cynthia Dowd ,  Audrey Odom John ,  Rachel Edwards ,  Kenneth M. Heidel ,  Xu Wang ,  Rene Chofor

IPC分类号： A61P31/04 ,  C07F9/40

CPC分类号： C07F9/4015 ,  A61P31/04 ,  C07F9/4009

摘要： The present disclosure provides method of treating or preventing a microbial infection caused by a prokaryotic pathogen in a subject, the method comprising administering a compound of Formula (I) as set forth in the specification. In one embodiment, the prokaryotic pathogen belongs to the genus Staphylococcus.

公开(公告)号：US11098072B2

公开(公告)日：2021-08-24

申请号：US16627004

申请日：2018-06-27

申请人： The George Washington University ,  Washington University in St. Louis ,  George Mason University ,  Saint Louis University

发明人： Cynthia Dowd ,  Xu Wang ,  Robert Carl Brothers ,  Audrey Ragan Odom John ,  Rachel Edwards ,  Marvin Meyers ,  Stacy Arnett ,  Robin Couch ,  Kenneth Heidel

IPC分类号： C07F9/38 ,  A61P33/06 ,  A61P31/06 ,  C07F9/40

摘要： The present disclosure relates to novel compounds, pharmaceutical compositions, and methods for treating or preventing microbial infection caused by parasites or bacteria, such as Plasmodium falciparum or related Plasmodium parasite species and Mycobacterium tuberculosis or related Mycobacterium bacteria species. The compounds are α,β-unsaturated analogs of fosmidomycin and can inhibit deoxyxylulose phosphate reductoisomerase (Dxr) in many microbes, such as P. falciparum.

公开(公告)号：US20190030056A1

公开(公告)日：2019-01-31

申请号：US16071459

申请日：2017-01-23

申请人： THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORA ,  WASHINGTON UNIVERSITY IN ST. LOUIS

发明人： Cynthia DOWD ,  Audrey ODOM ,  Rachel Edwards ,  Robert BROTHERS

IPC分类号： A61K31/7056 ,  A61P33/06 ,  A61K31/122 ,  A61K31/137 ,  A61K31/357 ,  A61K31/366 ,  A61K31/437 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/65

CPC分类号： A61K31/7056 ,  A61K31/122 ,  A61K31/137 ,  A61K31/155 ,  A61K31/357 ,  A61K31/366 ,  A61K31/437 ,  A61K31/4706 ,  A61K31/49 ,  A61K31/496 ,  A61K31/519 ,  A61K31/65 ,  A61K31/683 ,  A61K45/06 ,  A61P33/06 ,  Y02A50/411 ,  A61K2300/00

摘要： A pharmaceutical composition includes a small molecule and a pharmaceutically acceptable excipient. The small molecule interacts with a deoxyxylulose phosphate reductoisomerase (Dxr). A method for treating or preventing a microbial infection in a subject in need thereof includes administering the pharmaceutical composition. A method for inhibiting the growth of a eukaryotic pathogen includes contacting the eukaryotic pathogen with an effective amount of the pharmaceutical composition.

公开(公告)号：US20210261580A1

公开(公告)日：2021-08-26

申请号：US17253841

申请日：2019-06-18

申请人： THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFI1 ,  WASHINGTON UNIVERSITY

发明人： CYNTHIA DOWD ,  AUDREY ODOM JOHN ,  RACHEL EDWARDS ,  KENNETH M. HEIDEL ,  XU WANG ,  RENE CHOFOR

IPC分类号： C07F9/40 ,  A61P31/04

摘要： The present disclosure provides method of treating or preventing a microbial infection caused by a prokaryotic pathogen in a subject, the method comprising administering a compound of Formula (I) as set forth in the specification. In one embodiment, the prokaryotic pathogen belongs to the genus Staphylococcus.

公开(公告)号：US12121596B2

公开(公告)日：2024-10-22

申请号：US18327455

申请日：2023-06-01

申请人： Washington University

发明人： Samuel Achilefu ,  Rui Tang ,  Duanwen Shen ,  Avik Som ,  Baogang Xu ,  Gail Sudlow ,  Christopher Egbulefu ,  Partha Karmakar ,  Kexian Liang

IPC分类号： A61K49/00 ,  A61K9/00 ,  A61K9/19 ,  A61K47/42 ,  A61P35/00 ,  C09B69/10

CPC分类号： A61K49/0034 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/42 ,  A61K49/0056 ,  A61K49/0089 ,  A61P35/00 ,  C09B69/105

摘要： Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.

公开(公告)号：US20240345376A1

公开(公告)日：2024-10-17

申请号：US18642730

申请日：2024-04-22

申请人： The George Washington University

发明人： Inhee Chung

IPC分类号： G02B21/00

CPC分类号： G02B21/0088 ,  G02B21/0064 ,  G02B21/0068 ,  G02B21/0072

摘要： Systems and methods for microscopic imaging include an inverted microscope directed at a sample on a coverglass, where the sample is comprised of one or more cells and one or more chromophores. A ridge separates the coverglass from a silicon dioxide layer, and a silicon mirror is situated on the silicon dioxide layer, opposite the ridge and coverglass, while a weight is situated against the silicon mirror, opposite the silicon dioxide layer. The inverted microscope uses a spatial light modulator to diffract light through a linear polarizer and a filter wheel comprised of one or more Fourier filters. A beam or beams of s-polarized light is directed to the silicon mirror to create axial light modulation with its reflection on the silicon mirror, producing image data that is captured at a light detector.

公开(公告)号：US20240342220A1

公开(公告)日：2024-10-17

申请号：US18284487

申请日：2022-03-31

申请人： Washington University ,  Shriners Hospitals for Children

发明人： Farshid Guilak ,  Lara Pferdehirt

IPC分类号： A61K35/32 ,  A61K38/20 ,  C07K14/47 ,  C07K14/545 ,  C12N15/86

CPC分类号： A61K35/32 ,  A61K38/2006 ,  C07K14/4702 ,  C07K14/545 ,  C12N15/86 ,  C07K2319/92 ,  C12N2740/15043

摘要： Among the various aspects of the present disclosure is the provision of compositions and methods of making genetically modified cells comprising a synthetic circuit that is responsive to a circadian input to the cell and methods of use thereof. This disclosure uses a cells circadian rythym to provide gene-based delivery of biologic drugs at prescribed times, phases and frequencies. Once reprogrammed, the cells can be reimplanted in the body for this purpose.

公开(公告)号：US12119527B2

公开(公告)日：2024-10-15

申请号：US17521046

申请日：2021-11-08

申请人： Washington University

发明人： Shrihari Sankarasubramanian ,  Vijay K. Ramani

IPC分类号： H01M8/08 ,  H01M8/04791 ,  H01M8/083 ,  H01M8/1004 ,  H01M8/18

CPC分类号： H01M8/188 ,  H01M8/0482 ,  H01M8/083 ,  H01M8/1004 ,  H01M2300/0011

摘要： Disclosed herein is a redox flow battery (RFB). The battery generally includes: a positive electrolyte that is a first metal ion, a negative electrolyte that is a second metal ion, an ion exchange membrane positioned between the positive electrolyte and the negative electrolyte. The membrane is configured to restrict and/or prevent the passage of the first metal ion and/or the second metal ion therethrough, and is configured to maintain ionic conductivity between the positive electrolyte and the negative electrolyte.