公开(公告)号：US20190228837A1

公开(公告)日：2019-07-25

申请号：US16303899

申请日：2017-05-23

申请人： The Regents of the University of California ,  Shriners Hospitals for Children

发明人： Kiho Cho

IPC分类号： G16B30/00 ,  C12Q1/686 ,  C12Q1/6806 ,  G01N27/447 ,  G16B50/00 ,  G16B20/20 ,  G16B20/50

摘要： This disclosure relates to methods of creating dideoxynucleotide termination frequency (DTF) normalized landscape matrices and time/intensity (TI) normalized landscape matrices, and various applications of the normalized landscape matrices for genomic surveillance, identification, and monitoring of humans, animals, plants, cells and bacteria.

公开(公告)号：US10011638B2

公开(公告)日：2018-07-03

申请号：US15204695

申请日：2016-07-07

申请人： SHRINERS HOSPITALS FOR CHILDREN

发明人： Shuxin Li

IPC分类号： C07K7/08 ,  A61K47/64 ,  A61K38/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K47/645

摘要： The presently disclosed subject matter relates to antagonists of PTEN and methods of using the same. In particular, the presently disclosed subject matter provides for PTEN antagonist peptides for use in treating central nervous system disorders. In an exemplary embodiment, the presently disclosed subject matter provides methods for promoting nerve fiber growth in a subject by administering to the subject a therapeutically effective amount of a PTEN antagonist peptide.

公开(公告)号：US09517598B2

公开(公告)日：2016-12-13

申请号：US13971513

申请日：2013-08-20

申请人： University of South Florida ,  Shriners Hospitals for Children

发明人： W. Garrett Matthews ,  August Heim ,  Thomas J. Koob

IPC分类号： B29D11/00 ,  A61F2/14 ,  A61L27/24 ,  A61L27/36 ,  C07K1/14

CPC分类号： B29D11/00 ,  A61F2/142 ,  A61L27/24 ,  A61L27/3604 ,  A61L2430/16 ,  C07K1/14

摘要： A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into orthogonal stacks of lamellae comprised of aligned fibrils. The resulting structure is a transparent film of arbitrary thickness very similar in structure to mammalian corneal tissue.

公开(公告)号：US20140213474A1

公开(公告)日：2014-07-31

申请号：US14204787

申请日：2014-03-11

申请人： Shriners Hospitals for Children

发明人： Kiho Cho ,  David G. Greenhalgh

IPC分类号： C12Q1/68 ,  G01N33/74

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/743

摘要： Provided here in are, inter alia, methods of determining whether a patient is resistant or sensitive to glucocorticoid therapy.

摘要翻译： 其中提供了尤其是确定患者是否耐药或对糖皮质激素治疗敏感的方法。

公开(公告)号：US20210386464A1

公开(公告)日：2021-12-16

申请号：US17279631

申请日：2019-10-04

申请人： POLYVALOR, LIMITED PARTNERSHIP ,  SHRINERS HOSPITALS FOR CHILDREN

发明人： Jérémie GAUDREAU ,  Isabelle VILLEMURE ,  Mina MEKHAIL ,  Reggie HAMDY

IPC分类号： A61B17/80

摘要： An internal fixator apparatus comprises a barrel member having a bone interface adapted to be anchored to a first part of a bone in an extramedullary connection. A piston member has a bone interface adapted to be anchored to a first part of a bone, the piston member including a threaded nut portion, the barrel member and the piston member being operatively connected to concurrently form a joint whereby the barrel member and the piston member are displaceable at least in translation relative to one another. A fixator mechanism is inside the barrel member and the piston member, the fixator mechanism comprising at least a leadscrew threadingly engaged with the threaded nut portion, and at least one magnet connected to the leadscrew to rotate concurrently therewith, the magnet being rotatingly received in the barrel member.

公开(公告)号：US10472409B2

公开(公告)日：2019-11-12

申请号：US15431516

申请日：2017-02-13

申请人： Shriners Hospitals for Children

发明人： Thomas J. Koob ,  Douglas Pringle ,  Daniel Hernandez

IPC分类号： C07K14/78 ,  A61L27/24 ,  D06M13/152 ,  D06M101/14

摘要： The disclosure describes methods of making high-strength NDGA collagen and associated methods of preparing collagen preparatory material and medical bioprostheses.

公开(公告)号：US09888996B2

公开(公告)日：2018-02-13

申请号：US15184009

申请日：2016-06-16

申请人： Shriners Hospitals for Children

发明人： Thomas J. Koob ,  Douglas Pringle

IPC分类号： A61F2/08 ,  A61L27/24 ,  A61L27/50 ,  A61B90/00

CPC分类号： A61F2/08 ,  A61B2090/064 ,  A61F2/0811 ,  A61F2002/0817 ,  A61F2002/0835 ,  A61F2002/087 ,  A61F2002/0876 ,  A61F2002/0882 ,  A61F2002/0888 ,  A61F2210/0061 ,  A61F2250/001 ,  A61L27/24 ,  A61L27/50 ,  A61L2430/10

摘要： The disclosure describes implantable medical products, that include dry or partially hydrated biocompatible constructs comprising collagen fibers configured to expand in situ after implantation to frictionally engage a bone tunnel wall to thereby affix the construct in the bone tunnel.

公开(公告)号：US20160000468A1

公开(公告)日：2016-01-07

申请号：US14855147

申请日：2015-09-15

申请人： Shriners Hospitals For Children

发明人： Amer Samdani ,  Randal R. Betz

IPC分类号： A61B17/70

CPC分类号： A61B17/7022 ,  A61B17/7053 ,  A61B17/7077 ,  A61B17/7079 ,  A61B17/7086 ,  A61B17/7091

摘要： Method for performing spinal correction surgery. The method includes creating at least one access opening in a patient, and implanting a plurality of anchor devices through the at least one access opening onto a plurality of corresponding vertebral bodies. Each anchor device has a channel defined therein. The method further includes disposing a tether into the channel of each of the plurality of anchor devices. A first end portion of the tether is secured to a first of the plurality of anchor devices. Additionally, the method includes translating the vertebral body corresponding to the selected anchor device using a pusher tool. Furthermore, the method includes applying a tension to the tether using a tensioner.

摘要翻译： 执行脊柱矫正手术的方法 该方法包括在患者体内创建至少一个进入开口，以及将多个锚定装置通过至少一个进入开口植入到多个对应的椎体上。 每个锚定装置具有限定在其中的通道。 该方法还包括将系绳布置到多个锚定装置中的每一个的通道中。 系绳的第一端部固定到多个锚定装置中的第一个。 另外，该方法包括使用推动器工具平移与所选择的锚定装置相对应的椎体。 此外，该方法包括使用张紧器向系绳施加张力。

公开(公告)号：US20130337149A1

公开(公告)日：2013-12-19

申请号：US13971513

申请日：2013-08-20

申请人： Shriners Hospitals for Children ,  University of South Florida

发明人： W. Garrett Matthews ,  August Heim ,  Thomas J. Koob

IPC分类号： A61F2/14 ,  C07K1/14

CPC分类号： B29D11/00 ,  A61F2/142 ,  A61L27/24 ,  A61L27/3604 ,  A61L2430/16 ,  C07K1/14

摘要： A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into orthogonal stacks of lamellae comprised of aligned fibrils. The resulting structure is a transparent film of arbitrary thickness very similar in structure to mammalian corneal tissue.

摘要翻译： 衍生自海参胶原纤维的材料适用于角膜置换术或植入式隐形眼镜。 为了生产材料，胶原原纤维被离心成正交堆叠的由对齐的原纤维组成的片层。 所得结构是任意厚度的透明膜，其结构与哺乳动物角膜组织非常相似。

公开(公告)号：US20230349921A1

公开(公告)日：2023-11-02

申请号：US18173604

申请日：2023-02-23

申请人： Shriners Hospitals for Children

发明人： William A. Horton ,  Gregory P. Lunstrum ,  Ryan F. Coghlan ,  Jon A. Oberdorf

IPC分类号： G01N33/68 ,  G01N33/50 ,  G01N33/543 ,  G01N33/566 ,  C07K14/78 ,  G01N33/535 ,  G01N33/574

CPC分类号： G01N33/6887 ,  C07K14/78 ,  G01N33/5029 ,  G01N33/5044 ,  G01N33/5082 ,  G01N33/535 ,  G01N33/54306 ,  G01N33/566 ,  G01N33/57488 ,  A61K38/00 ,  G01N2800/10 ,  G01N2800/52 ,  G01N2800/60

摘要： The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.