公开(公告)号：US20240342220A1

公开(公告)日：2024-10-17

申请号：US18284487

申请日：2022-03-31

申请人： Washington University ,  Shriners Hospitals for Children

发明人： Farshid Guilak ,  Lara Pferdehirt

IPC分类号： A61K35/32 ,  A61K38/20 ,  C07K14/47 ,  C07K14/545 ,  C12N15/86

CPC分类号： A61K35/32 ,  A61K38/2006 ,  C07K14/4702 ,  C07K14/545 ,  C12N15/86 ,  C07K2319/92 ,  C12N2740/15043

摘要： Among the various aspects of the present disclosure is the provision of compositions and methods of making genetically modified cells comprising a synthetic circuit that is responsive to a circadian input to the cell and methods of use thereof. This disclosure uses a cells circadian rythym to provide gene-based delivery of biologic drugs at prescribed times, phases and frequencies. Once reprogrammed, the cells can be reimplanted in the body for this purpose.

公开(公告)号：US20240254510A1

公开(公告)日：2024-08-01

申请号：US18282761

申请日：2022-03-21

申请人： Washington University ,  Shriners Hospitals for Children

发明人： Farshid Guilak ,  Robert Nims ,  Lara Pferdehirt

IPC分类号： C12N15/86 ,  C07K14/52 ,  C12N5/077

CPC分类号： C12N15/86 ,  C07K14/52 ,  C12N5/0655 ,  C12N2510/00 ,  C12N2740/15043 ,  C12N2830/002

摘要： Among the various aspects of the present disclosure is the provision of compositions and methods of making genetically modified cells comprising a synthetic circuit that is responsive to a mechanical input to the cell and methods of use thereof. This disclosure uses mechanotransduction to provide gene-based delivery of biologic drugs at prescribed times, phases and frequencies. Once reprogrammed, the cells can be reimplanted in the body for this purpose.