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公开(公告)号：US20240325593A1
公开(公告)日：2024-10-03
申请号：US18400466
申请日：2023-12-29
IPC分类号： A61L24/06 , A61B8/08 , A61B17/12 , A61B17/34 , A61B17/42 , A61F6/22 , A61K49/22 , A61L24/00 , A61L27/52 , A61L27/54
CPC分类号： A61L24/06 , A61B8/0833 , A61B8/0841 , A61B8/085 , A61B17/12 , A61B17/12022 , A61B17/12186 , A61B17/3403 , A61F6/22 , A61K49/223 , A61K49/226 , A61L24/001 , A61L24/0015 , A61L24/0031 , A61L24/0036 , A61L27/52 , A61L27/54 , A61B8/0891 , A61B8/481 , A61B8/488 , A61B2017/3413 , A61B17/42 , A61L2300/626 , A61L2400/06 , A61L2430/36
摘要： Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.
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公开(公告)号：US11369569B2
公开(公告)日：2022-06-28
申请号：US15737047
申请日：2016-06-15
摘要： Isolated peptides targeting cardiovascular disease are described herein or one or more conservative amino acid substitutions, deletions or additions of such peptides and methods of use thereof for delivering payloads to specific cell types or tissues.
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公开(公告)号：US20220168461A1
公开(公告)日：2022-06-02
申请号：US17651509
申请日：2022-02-17
IPC分类号： A61L24/06 , A61L27/52 , A61L27/54 , A61K49/22 , A61B8/08 , A61B17/12 , A61B17/34 , A61F6/22 , A61L24/00
摘要： Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.
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公开(公告)号：US20180360755A1
公开(公告)日：2018-12-20
申请号：US15737047
申请日：2016-06-15
摘要： Isolated peptides targeting cardiovascular disease are described herein or one or more conservative amino acid substitutions, deletions or additions of such peptides and methods of use thereof for delivering payloads to specific cell types or tissues.
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公开(公告)号：US11278641B2
公开(公告)日：2022-03-22
申请号：US16173539
申请日：2018-10-29
IPC分类号： A61F6/22 , A61L24/06 , A61L27/52 , A61L27/54 , A61K49/22 , A61B8/08 , A61B17/12 , A61B17/34 , A61L24/00 , A61B17/42
摘要： Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.
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公开(公告)号：US09949722B2
公开(公告)日：2018-04-24
申请号：US14559422
申请日：2014-12-03
CPC分类号： A61B8/481 , A61B8/0891 , A61B8/587 , G06T7/0016 , G06T2207/10132 , G06T2207/30104
摘要： An ultrasound system and method that can include: a receive beamformer configured to receive signals from a transducer; a processor coupled to the receive beamformer, the processor configured to: analyze echo data reflected from a region of interest, the echo data elicited by a transmitted pulse sequence; using the echo data, determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest; determine a time series of the signal magnitude; using the time series, determine an initial signal magnitude parameter; obtain a saturated signal parameter and a residual signal parameter using the time series; and determine a relative indication of information indicative of the residual signal magnitude versus the saturated signal magnitude.
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7.发明授权System for treatment and imaging using ultrasonic energy and microbubbles and related method thereof 有权使用超声波能量和微泡进行治疗和成像的系统及其相关方法公开(公告)号：US09526922B2
公开(公告)日：2016-12-27
申请号：US14063830
申请日：2013-10-25
CPC分类号： A61N7/00 , A61B8/12 , A61B8/445 , A61B8/481 , A61B17/2202 , A61B2017/22088 , A61B2017/22089 , A61B2090/3782 , A61K41/0028 , A61K49/223 , A61M37/0092
摘要： A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.
摘要翻译： 用于在受试者的一个或多个位置（例如脉管系统）向治疗部位提供治疗的方法和相关系统，例如狭窄或其它脉管系统疾病。 该方法包括：将超声导管推进到受试者的治疗部位或其附近; 将微泡注入或接近治疗部位; 并从超声导管输送超声波能量。 超声波能量可以适于：对治疗部位进行成像，将微泡翻译成治疗部位或其附近和/或破裂微泡。
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公开(公告)号：US11904068B2
公开(公告)日：2024-02-20
申请号：US17651509
申请日：2022-02-17
IPC分类号： A61B17/34 , A61F6/22 , A61L24/00 , A61L24/06 , A61L27/52 , A61L27/54 , A61K49/22 , A61B8/08 , A61B17/12 , A61B17/42
CPC分类号： A61L24/06 , A61B8/085 , A61B8/0833 , A61B8/0841 , A61B17/12 , A61B17/12022 , A61B17/12186 , A61B17/3403 , A61F6/22 , A61K49/223 , A61K49/226 , A61L24/001 , A61L24/0015 , A61L24/0031 , A61L24/0036 , A61L27/52 , A61L27/54 , A61B8/0891 , A61B8/481 , A61B8/488 , A61B17/42 , A61B2017/3413 , A61L2300/626 , A61L2400/06 , A61L2430/36
摘要： Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.
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公开(公告)号：US10507315B2
公开(公告)日：2019-12-17
申请号：US14964454
申请日：2015-12-09
IPC分类号： A61M37/00 , A61B8/12 , A61B8/08 , A61B17/22 , A61N7/00 , A61B8/00 , A61M25/00 , A61B5/00 , A61B6/00 , A61B8/06 , A61B17/00 , A61M25/10 , A61B90/00
摘要： A catheter system including an elongate tubular member having a proximal end portion, a distal end portion and a lumen extending through at least a portion of a length of the elongate tubular member. The distal end portion of the elongate member is dimensioned and adapted to advance to or in proximity to a treatment site of a subject. A microbubble device is in fluid communication with the lumen. The microbubble device includes at least one input port for receiving a flow of material into the device and an output port configured to output microbubbles from the microbubble device. A second tubular member is in fluid communication with one of the at least one input ports. A pressure fitting arrangement is adapted to maintain a seal between the second tubular member and the input port.
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10.发明申请公开(公告)号：US20160206867A1
公开(公告)日：2016-07-21
申请号：US14964454
申请日：2015-12-09
CPC分类号： A61M37/0092 , A61B5/7285 , A61B6/503 , A61B6/504 , A61B6/541 , A61B8/06 , A61B8/0891 , A61B8/12 , A61B8/445 , A61B8/481 , A61B8/543 , A61B17/22 , A61B17/22004 , A61B17/2202 , A61B2017/00893 , A61B2017/22021 , A61B2017/22054 , A61B2017/22067 , A61B2017/22088 , A61B2017/22089 , A61B2090/3735 , A61B2090/3784 , A61M25/00 , A61M25/0082 , A61M25/10 , A61M37/00 , A61M2025/0073 , A61M2025/1052 , A61N7/00 , A61N2007/0039 , A61N2007/0043
摘要： A catheter system including an elongate tubular member having a proximal end portion, a distal end portion and a lumen extending through at least a portion of a length of the elongate tubular member. The distal end portion of the elongate member is dimensioned and adapted to advance to or in proximity to a treatment site of a subject. A microbubble device is in fluid communication with the lumen. The microbubble device includes at least one input port for receiving a flow of material into the device and an output port configured to output microbubbles from the microbubble device. A second tubular member is in fluid communication with one of the at least one input ports. A pressure fitting arrangement is adapted to maintain a seal between the second tubular member and the input port.
摘要翻译： 导管系统，其包括细长管状构件，其具有近端部分，远端部分和延伸穿过细长管状构件的长度的至少一部分的内腔。 细长构件的远端部分的尺寸和尺寸适于前进到或接近受试者的治疗部位。 微泡装置与内腔流体连通。 微泡装置包括至少一个用于接收材料流入装置的输入端口和配置成从微泡装置输出微气泡的输出端口。 第二管状构件与所述至少一个输入端口中的一个流体连通。 压力配合装置适于在第二管状构件和输入端口之间保持密封。
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