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公开(公告)号：US10247646B2
公开(公告)日：2019-04-02
申请号：US14642698
申请日：2015-03-09
Applicant: Shazi S Iqbal , Steven M Montgomery , Ronald Chang , Gregory E Mote , Douglas B Dority , Jeffrey S Ross
Inventor： Shazi S Iqbal , Steven M Montgomery , Ronald Chang , Gregory E Mote , Douglas B Dority , Jeffrey S Ross
Abstract: A self-contained biological sample processing cartridge includes top and bottom portions that close together to form a sealed chamber therein. The chamber is configured to enable one of one or more biological sample staining procedures appropriate for a biological sample. The top portion includes a chamber top section and valve control elements. The bottom portion includes a chamber bottom section and fluidic valves. One of the fluid valves evacuates the contents of the chamber. One of the valve control elements couples to a respective fluidic valve to control fluid flow for the chamber. The cartridge includes a preloaded reagent component to supply the chamber with the reagent component appropriate for a particular biological sample staining procedure. A user desiring to conduct a particular biological sample staining procedure may select a particular cartridge that is preloaded with the preloaded reagent fluidic valves component appropriate for the particular biological sample staining procedure.
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公开(公告)号：US09073053B2
公开(公告)日：2015-07-07
申请号：US11233629
申请日：2005-09-22
Applicant: Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching
Inventor： Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching
CPC classification number: B01L3/502 , B01L2200/10 , B01L2300/0681 , B01L2400/0487 , B01L2400/0644 , B01L2400/0655 , C12M47/06
Abstract: An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
Abstract translation: 用于破坏细胞或病毒的装置包括具有用于保持细胞或病毒的室的容器。 容器包括限定腔室的至少一个柔性壁。 该装置还包括用于冲击柔性壁的外表面的换能器，以在腔室中产生压力波。 该装置还包括用于增加腔室中的压力的压力源。 室的加压确保换能器与柔性壁之间的有效耦合。 该装置还可以包括室中的珠子，用于破裂细胞或病毒。
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公开(公告)号：US08975039B2
公开(公告)日：2015-03-10
申请号：US12135925
申请日：2008-06-09
Applicant: Shazi Iqbal , Steven M. Montgomery , Ronald Chang , Gregory Mote , Douglas B Dority , Jeffrey S. Ross
Inventor： Shazi Iqbal , Steven M. Montgomery , Ronald Chang , Gregory Mote , Douglas B Dority , Jeffrey S. Ross
CPC classification number: G01N1/312 , G01N1/30 , G01N1/38 , G01N35/00029 , G01N35/0092 , G01N2001/386 , G01N2035/00534 , G01N2035/00792 , G01N2035/00811 , Y10T436/112499 , Y10T436/25 , Y10T436/2525
Abstract: Provided is a system and method for staining of one or more samples, including providing one or more self-contained sample processing receptacles, each of the one or more self-contained sample processing receptacles configured to be inserted into an auto-staining instrument; and enabling one of one or more staining procedures appropriate for the one or more samples as a function of a choice of self-contained sample processing receptacle, each of the one or more self-contained sample processing receptacles configured to process each inserted sample of the one or more samples within the self-contained sample processing receptacle.
Abstract translation: 提供了一种用于染色一个或多个样品的系统和方法，包括提供一个或多个独立的样品处理容器，所述一个或多个独立样品处理容器中的每一个被配置为插入自动染色仪器中; 以及使得适合于所述一个或多个样品的一个或多个染色程序中的一个作为自选样品处理容器的选择的功能，所述一个或多个独立样品处理容器中的每一个被配置成处理每个插入的样品 独立样品处理容器内的一个或多个样品。
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4.发明授权Methodology of on-chip soft-start circuits for switching mode DC/DC converter 有权开关模式DC / DC转换器的片上软启动电路方法公开(公告)号：US08810225B2
公开(公告)日：2014-08-19
申请号：US13338004
申请日：2011-12-27
Applicant: Chung-Kuang Huang , Xiao-Ming Duan , Ronald Chang
Inventor： Chung-Kuang Huang , Xiao-Ming Duan , Ronald Chang
CPC classification number: H02M3/158 , H02M1/36 , Y10S323/901 , Y10S323/908
Abstract: Methods of a switching mode DC/DC converter are provided in the present invention. The proposed method includes a step of causing a switching frequency of the converter to be operated at a rated value multiplied by a second predetermined value when an output voltage of the converter is not larger than a first predetermined value.
Abstract translation: 在本发明中提供了开关模式DC / DC转换器的方法。 所提出的方法包括当转换器的输出电压不大于第一预定值时，使转换器的开关频率工作在额定值乘以第二预定值的步骤。
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公开(公告)号：US08390262B2
公开(公告)日：2013-03-05
申请号：US12620589
申请日：2009-11-17
Applicant: Ronald Chang , Chin-Chi Chang , Chung-Kuang Huang
Inventor： Ronald Chang , Chin-Chi Chang , Chung-Kuang Huang
IPC: G05F1/00
CPC classification number: H05B33/0818 , G09G3/3413 , G09G3/342 , G09G2310/024 , G09G2320/064 , G09G2320/0693 , G09G2330/021 , H05B33/0827
Abstract: The present invention relates to methods for LED driver applications, comprising the steps: providing an input voltage, Vin; generating an output voltage, Vout, for driving a plurality of LED channels, wherein a boost converter is used to convert the input voltage Vin to the output voltage Vout; determining a lowest voltage, VLVS, from the LED channels; generating a comparator voltage, Vcomp, by comparing the lowest voltage of the channels, VLVS, with a feedback reference voltage, VFBREF, wherein the feedback reference voltage, VFBREF, and a LED current, ILED, for the LED channels are determined by a current ISET; generating a summed voltage, Vsum, for stabilizing the output voltage, Vout; and generating a PWM voltage, VPWM, as a function of the Vcomp and the Vsum to control the output voltage, Vout.
Abstract translation: 本发明涉及LED驱动器应用的方法，包括以下步骤：提供输入电压Vin; 产生用于驱动多个LED通道的输出电压Vout，其中使用升压转换器将输入电压Vin转换为输出电压Vout; 从LED通道确定最低电压VLVS; 通过将通道的最低电压VLVS与反馈参考电压VFBREF进行比较来产生比较器电压Vcomp，其中用于LED通道的反馈参考电压VFBREF和LED电流ILED由电流确定 我设置; 产生用于稳定输出电压Vout的总和电压Vsum; 并产生作为V comp和Vsum的函数的PWM电压VPWM，以控制输出电压Vout。
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Patent Agency Ranking
公开(公告)号：US20120295269A1
公开(公告)日：2012-11-22
申请号：US13552950
申请日：2012-07-19
Applicant: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
Inventor： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
CPC classification number: C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
Abstract translation: 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。
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公开(公告)号：US20120288924A1
公开(公告)日：2012-11-15
申请号：US13436475
申请日：2012-03-30
Applicant: Kurt E. Peterson , William A. McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
Inventor： Kurt E. Peterson , William A. McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
CPC classification number: B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
Abstract: A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
Abstract translation: 用于进行化学反应的药筒包括具有形成在其中的至少一个流路的主体。 药筒还包括从身体延伸的反应容器，用于保持用于化学反应和光学检测的反应混合物。 容器包括限定反应室侧壁的刚性框架。 该框架包括连接到该腔室的流动路径的至少一个通道。 容器还包括附接到刚性框架的相对侧的柔性膜或片，以形成腔室的相对的主壁。 此外，至少两个侧壁是光学透射的并且与每个侧壁成角度地偏移以允许对反应室中的分析物的实时光学检测。
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公开(公告)号：US20110165562A1
公开(公告)日：2011-07-07
申请号：US13042203
申请日：2011-03-07
Applicant: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
Inventor： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
CPC classification number: C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
Abstract translation: 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。
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公开(公告)号：US20100084402A1
公开(公告)日：2010-04-08
申请号：US12575872
申请日：2009-10-08
Applicant: Ronald Chang
Inventor： Ronald Chang
IPC: B65D17/42
CPC classification number: B01L3/50825 , B01L2200/141 , B01L2300/043 , B01L2300/047 , B01L2300/0672 , B01L2400/0683
Abstract: Embodiments of the invention provide a cap for a vessel for performing a multi-stage process for analyzing a sample, such as nested PCR or RT-PCR. In one embodiment, the cap comprises a body configured to be mated to the vessel to enclose a vessel interior, a cap cavity for holding reagents, and a cap cavity control portion that is adjustable with respect to the body between a first-stage position in which the cap cavity is enclosed and fluidicly isolated from the vessel interior and a second-stage position in which the cap cavity is fluidicly coupled with the vessel interior.
Abstract translation: 本发明的实施方案提供了用于进行用于分析样品的多级方法（例如巢式PCR或RT-PCR）的容器的盖。 在一个实施例中，盖包括构造成与容器配合以封闭容器内部的主体，用于保持试剂的盖腔，以及帽腔控制部分，其在相对于主体的第一阶段位置之间相对于主体可调节 盖腔被封闭并与容器内部流体隔离，第二级位置中帽腔与容器内部流体连接。
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公开(公告)号：US20100068706A1
公开(公告)日：2010-03-18
申请号：US12370527
申请日：2009-02-12
Applicant: Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
Inventor： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
CPC classification number: C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
Abstract: An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
Abstract translation: 将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。 第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。 所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。 样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。 然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。
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