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    Dual piston rotary valve
    6.
    发明授权
    Dual piston rotary valve 失效
    双活塞旋转阀

    公开(公告)号：US07032605B1

    公开(公告)日：2006-04-25

    申请号：US10687227

    申请日：2003-10-15

    Applicant: Douglas B. Dority

    Inventor： Douglas B. Dority

    IPC: F16K11/10

    CPC classification number: F16K27/12 ,  Y10T137/0318 ,  Y10T137/87877 ,  Y10T137/87909 ,  Y10T137/87917

    Abstract: Apparatus and methods are provided for manipulating fluids, for instance, to determine the presence or absence of an analyte in a sample. In one embodiment, a fluid control and processing system comprises a plurality of chambers; a body including a fluid sample processing region; and a plurality of valves. Each valve includes a valve body having a fluid displacement region which is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region, the valve body including an external port. The fluid displacement region is fluidicly coupled with the external port of the valve body. The valve body is adjustable with respect to the fluid sample processing region to place the external port selectively in fluidic communication with the fluid sample processing region. The valve body is adjustable with respect to the plurality of chambers to allow the external port to be placed selectively in fluidic communication with the plurality of chambers.

    Abstract translation: 提供了用于操纵流体的设备和方法，例如以确定样品中分析物的存在或不存在。 在一个实施例中，流体控制和处理系统包括多个室; 包括流体样品处理区域的主体; 和多个阀。 每个阀都包括具有流体位移区域的阀体，所述流体位移区域是可减压的，以将流体吸入流体移动区域并且可加压以从流体排放区域排出流体，所述阀体包括外部端口。 流体位移区域与阀体的外部端口流体耦合。 阀体相对于流体样品处理区域是可调节的，以将外部端口选择性地与流体样品处理区域流体连通。 阀体相对于多个室可调，以允许外部端口选择性地与多个室流体连通。

    Reaction vessel and temperature control system
    8.
    发明授权
    Reaction vessel and temperature control system 有权
    反应容器和温度控制系统

    公开(公告)号：US06403037B1

    公开(公告)日：2002-06-11

    申请号：US09497848

    申请日：2000-02-04

    Applicant: Ronald Chang ,  Douglas B. Dority ,  Lee A. Christel ,  Kurt E. Petersen

    Inventor： Ronald Chang ,  Douglas B. Dority ,  Lee A. Christel ,  Kurt E. Petersen

    IPC: G01N1506

    CPC classification number: B01L3/502 ,  B01L3/50825 ,  B01L7/52 ,  B01L2200/026 ,  B01L2200/0642 ,  B01L2200/0684 ,  B01L2300/0654 ,  B01L2300/14 ,  B01L2400/049 ,  B01L2400/0644 ,  G01N2035/0405 ,  Y10T436/2575

    Abstract: The invention provides a reaction vessel and temperature control system for performing heat-exchanging chemical reactions, such as nucleic acid amplification. The vessel has a body defining a reaction chamber, and a loading structure extending from the body for loading a sample into the chamber. The loading structure has a loading reservoir, an aspiration port, and respective fluid channels connecting the loading reservoir and aspiration port to the chamber. To load the sample into the vessel, the sample is first dispensed into the loading reservoir and then drawn into the chamber by application of a vacuum to the aspiration port. The vessel also includes a seal aperture extending over the outer ends of the loading reservoir and aspiration port. A plug is inserted into the aperture after loading the sample into the chamber to simultaneously seal the chamber, loading reservoir, and aspiration port from the external environment. The temperature of the sample is controlled by opposing plates positioned to contact opposite sides of the vessel. The system also,includes thermal elements for heating or cooling the plates and optics for detecting one or more analytes in the sample.

    Abstract translation: 本发明提供了用于进行热交换化学反应如核酸扩增的反应容器和温度控制系统。 容器具有限定反应室的主体和从主体延伸以将样品装载到室中的装载结构。 装载结构具有装载储存器，抽吸端口和将装载储存器和抽吸端口连接到室的各个流体通道。 为了将样品装载到容器中，首先将样品分配到装载容器中，然后通过向抽吸端口施加真空而将其抽吸到室中。 容器还包括在装载容器和抽吸端口的外端上延伸的密封孔。 将样品装入室后，将插头插入孔中，以同时将腔室，装载储存器和抽吸端口从外部环境密封。 样品的温度由位于容器相对侧的相对板控制。 该系统还包括用于加热或冷却板的热元件和用于检测样品中的一种或多种分析物的光学元件。

    Method and apparatus for storing and dispensing reagent beads
    10.
    发明授权
    Method and apparatus for storing and dispensing reagent beads 有权
    用于存储和分配试剂珠的方法和装置

    公开(公告)号：US08409531B2

    公开(公告)日：2013-04-02

    申请号：US12512926

    申请日：2009-07-30

    Applicant: Ronald Chang ,  Douglas B. Dority ,  Steve Montgomery

    Inventor： Ronald Chang ,  Douglas B. Dority ,  Steve Montgomery

    IPC: B01L3/00 ,  G01N31/00 ,  G01N33/543 ,  B65G47/14 ,  B23Q7/04 ,  B65H3/06 ,  B65H3/24 ,  B65H3/44 ,  B65H1/08 ,  B65H3/00 ,  G01N1/00 ,  G07F9/00 ,  G07F11/16 ,  B65G59/00

    CPC classification number: B01L3/527 ,  B01J19/0046 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00657 ,  B01L3/0289 ,  B01L2200/0647 ,  B01L2200/16 ,  G01N2035/00574 ,  Y10T436/25

    Abstract: Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in which to place the bead storage device with the bead carrier facing a support wall of the channel and the cover tape facing a stripping wall of the channel. The stripping wall includes a stripping gap disposed between a stripping edge and an opposite edge, and a dispense opening provided adjacent the opposite edge on a side of the stripping wall opposite from the stripping edge. The cover tape is insertable through the stripping gap to be pulled against the stripping edge to peel the cover tape from the bead carrier to move the wells of the bead carrier inside the channel toward the dispense opening and expose the wells individually to dispense the reagent beads.

    Abstract translation: 本发明的实施方案提供了用于存储和分配试剂珠的有效和有效的技术。 在一些实施例中，提供了一种用于分配包含在珠子存储装置中的试剂珠粒的装置，其包括具有多个孔的珠粒载体; 设置在所述孔中的多个试剂珠; 以及可剥离地附接到胎圈载体以覆盖孔并将试剂珠保持在孔中的覆盖带。 该装置包括一个通道，在该通道中，珠子存放装置使胎圈承载件面向通道的支撑壁，盖带面向通道的剥离壁。 剥离壁包括设置在剥离边缘和相对边缘之间的剥离间隙，以及在剥离壁的与剥离边缘相对的一侧上邻近相对边缘设置的分配开口。 覆盖带可以通过剥离间隙被插入以被拉靠在剥离边缘上，以从胎圈载体上剥离覆盖带，以将通道内的胎圈载体的孔移动到分配开口，并单独暴露孔以分配试剂珠 。

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