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公开(公告)号：US20230251133A1
公开(公告)日：2023-08-10
申请号：US18130867
申请日：2023-04-04
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A flow cytometry measurement system is disclosed which includes a flow chamber configured to flow particles of interest in a flow stream, one or more optical sources configured to excite the particles of interest by an excitation light activated and deactivated according to a pulse train thus causing particles of interest emitting emission light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the particles of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the particles of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
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公开(公告)号：US12078539B2
公开(公告)日：2024-09-03
申请号：US18375404
申请日：2023-09-29
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , Keegan Hernandez , J. Paul Robinson
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A measurement system is disclosed which includes a flow chamber configured to propagate a sample in a flow stream, one or more optical sources configured to irradiate the sample in the flow stream, one or more detector systems each configured to receive resultant light from the sample and, in response, generate a photon signal, the one or more detector systems each including one or more photon sensors each adapted to generate an electronic pulse in response to receiving a photon and a circuit operating in the giga hertz supporting the one or more photon sensors thus configured to count each individual photon in the resultant light from the sample.
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公开(公告)号：US20240027270A1
公开(公告)日：2024-01-25
申请号：US18375404
申请日：2023-09-29
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , Keegan Hernandez , J. Paul Robinson
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A measurement system is disclosed which includes a flow chamber configured to propagate a sample in a flow stream, one or more optical sources configured to irradiate the sample in the flow stream, one or more detector systems each configured to receive resultant light from the sample and, in response, generate a photon signal, the one or more detector systems each including one or more photon sensors each adapted to generate an electronic pulse in response to receiving a photon and a circuit operating in the giga hertz supporting the one or more photon sensors thus configured to count each individual photon in the resultant light from the sample.
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公开(公告)号：US20240035951A1
公开(公告)日：2024-02-01
申请号：US18379775
申请日：2023-10-13
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , J. Paul Robinson , Keegan Hernandez
IPC: G01N15/14
CPC classification number: G01N15/1429 , G01N15/1434
Abstract: A system is described wherein a plurality of lasers are used to irradiate particles in a flow cytometer's flow stream. In certain embodiments, a light source having a plurality of lasers configured for irradiation of a flow stream are disclosed where discrete intervals of irradiation by one or more discretely activated lasers are triggered by irradiation of one or more particles in the flow stream with one or more continuously on lasers.
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公开(公告)号：US11781912B2
公开(公告)日：2023-10-10
申请号：US17536068
申请日：2021-11-28
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , Keegan Hernandez , J. Paul Robinson
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: A measurement system includes an optical source (e.g., laser) to irradiate a sample (e.g., a cell); a solid-state photon detector (SSPD) to receive resultant light from the sample; and a photon counter to count photons received by the SSPD. The photon counter can include a differentiator to provide a differentiated photon signal and a crossing detector configured to count photons based on a number of times the differentiated photon signal crosses a predetermined threshold level. In some examples, a pulse detector can provide a pulse-width signal from the SSPD output photon signal, and a pulse counter can count based on both a number of pulses and widths of the pulses. The SSPD can include a silicon photomultiplier (SiPM) array or a solid-state photomultiplier. Some examples use the measurement system to measure samples in fluids, e.g., in flow cytometers or multi-well plates.
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Patent Agency Ranking
公开(公告)号：US20250020512A1
公开(公告)日：2025-01-16
申请号：US18786743
申请日：2024-07-29
Applicant: MIFTEK CORPORATION
Abstract: A measurement system is disclosed which includes a vessel configured to suspend molecules of interest therein, optical sources configured to excite the molecules of interest by an excitation light activated and deactivated in a repeating fashion, during the activation, the sources activated according to a predetermined pattern, the molecules of interest emitting emission light in response to being excited by the excitation light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the molecules of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the molecules of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
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公开(公告)号：US11874171B2
公开(公告)日：2024-01-16
申请号：US18130871
申请日：2023-04-04
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: An optical underwater communication system is disclosed which includes a first transceiver and a second transceiver, each including one or more optical sources configured to provide light activated and deactivated according to a first bit stream, one or more sensor packages each comprising a plurality of photodetectors configured to receive light from the other transceiver and, in response, provide an output voltage signal and an output current signal, a detector configured to i) convert the output voltage signal and the output current signal to pulses associated with arrival of photons, and ii) count the number of pulses based on a predetermined timing sequence, an encoder configured to encode a message to be sent into a first bit stream, and a decoder configured to decode a message received into a second bit stream.
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公开(公告)号：US11788945B2
公开(公告)日：2023-10-17
申请号：US17583062
申请日：2022-01-24
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , J. Paul Robinson , Keegan Hernandez
IPC: G01N15/14
CPC classification number: G01N15/1429 , G01N15/1434
Abstract: A system is described wherein multiple lasers are used to irradiate particles in a flow cytometer's flow stream. In certain embodiments, a light source having a first laser configured for continuous irradiation of a flow stream and one or more second lasers configured for irradiation of the flow stream in discrete intervals where each discrete interval of irradiation by the second laser is triggered by irradiation of one or more particles in the flow stream with the first laser. Methods for modulating the laser irradiation and measuring light intensity are also described. Also described is the computations and systems required to operate the one or more second lasers.
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公开(公告)号：US20230251134A1
公开(公告)日：2023-08-10
申请号：US18130871
申请日：2023-04-04
Applicant: MIFTEK CORPORATION
CPC classification number: G01J3/4406 , G01J3/0218 , G01J3/0227
Abstract: An optical underwater communication system is disclosed which includes a first transceiver and a second transceiver, each including one or more optical sources configured to provide light activated and deactivated according to a first bit stream, one or more sensor packages each comprising a plurality of photodetectors configured to receive light from the other transceiver and, in response, provide an output voltage signal and an output current signal, a detector configured to i) convert the output voltage signal and the output current signal to pulses associated with arrival of photons, and ii) count the number of pulses based on a predetermined timing sequence, an encoder configured to encode a message to be sent into a first bit stream, and a decoder configured to decode a message received into a second bit stream.
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公开(公告)号：US20250130156A1
公开(公告)日：2025-04-24
申请号：US19001320
申请日：2024-12-24
Applicant: MIFTEK CORPORATION
Inventor： Masanobu Yamamoto , J. Paul Robinson , Keegan Hernandez
IPC: G01N15/1429 , G01N15/1434
Abstract: A method is described wherein a plurality of lasers are used to irradiate particles in a flow cytometer's flow stream. In certain embodiments, a light source having a plurality of lasers configured for irradiation of a flow stream are disclosed where discrete intervals of irradiation by one or more discretely activated lasers are triggered by irradiation of one or more particles in the flow stream with one or more continuously on lasers.
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