公开(公告)号：US11653834B2

公开(公告)日：2023-05-23

申请号：US17462824

申请日：2021-08-31

申请人： The Trustees of Columbia University in the City of New York

发明人： Elizabeth Marjorie Clare Hillman ,  Sean A. Burgess

IPC分类号： A61B5/00 ,  G01J3/28 ,  G01J3/42 ,  G01J3/457 ,  G02B26/10 ,  G02B23/24

CPC分类号： A61B5/0064 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/444 ,  A61B5/445 ,  G01J3/2889 ,  G01J3/42 ,  G01J3/457 ,  G02B23/2476 ,  G02B26/101 ,  A61B5/0088 ,  A61B2562/0238 ,  A61B2562/0242

摘要： Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).

公开(公告)号：US20180214024A1

公开(公告)日：2018-08-02

申请号：US15915180

申请日：2018-03-08

申请人： The Trustees of Columbia University in the City of New York

发明人： Elizabeth Marjorie Clare HILLMAN ,  Sean A. BURGESS

IPC分类号： A61B5/00 ,  G01J3/457 ,  G01J3/42 ,  G01J3/28 ,  G02B23/24 ,  G02B26/10

CPC分类号： A61B5/0064 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0088 ,  A61B5/444 ,  A61B5/445 ,  A61B2562/0238 ,  A61B2562/0242 ,  G01J3/2889 ,  G01J3/42 ,  G01J3/457 ,  G02B23/2476 ,  G02B26/101

摘要： Optical imaging or spectroscopy described can use laminar optical tomography (LOT), diffuse correlation spectroscopy (DCS), or the like. An incident beam is scanned across a target. An orthogonal or oblique optical response can be obtained, such as concurrently at different distances from the incident beam. The optical response from multiple incident wavelengths can be concurrently obtained by dispersing the response wavelengths in a direction orthogonal to the response distances from the incident beam. Temporal correlation can be measured, from which flow and other parameters can be computed. An optical conduit can enable endoscopic or laparoscopic imaging or spectroscopy of internal target locations. An articulating arm can communicate the light for performing the LOT, DCS, or the like. The imaging can find use for skin cancer diagnosis, such as distinguishing lentigo maligna (LM) from lentigo maligna melanoma (LMM).

公开(公告)号：US09482577B2

公开(公告)日：2016-11-01

申请号：US14494315

申请日：2014-09-23

申请人： University of Virginia Patent Foundation

发明人： Brooks Hart Pate ,  Justin L. Neill

IPC分类号： G01J3/30 ,  G01J3/443 ,  G01J3/28 ,  G01J3/433 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3586

CPC分类号： G01J3/443 ,  G01J3/2889 ,  G01J3/4338 ,  G01J3/453 ,  G01N21/35 ,  G01N21/3586 ,  G01N2021/3595

摘要： An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.

摘要翻译： 可以使用特定范围的激发频率响应于激发而从样品获得发射。 这种激励可以包括使用数模转换器（DAC）产生指定的啁啾波形和指定的下变频本地振荡器（LO）频率，通过将啁啾波形与指定的上变频LO频率混频来上变频啁啾波形， 上变频啁啾波形以提供用于激发采样的啁啾激励信号，接收来自采样的发射，至少部分地由啁啾激励信号引起的发射，以及通过基于指定的信号将接收到的发射与信号进行混合来下变频接收的发射 下变频LO信号，以在模数转换器（ADC）的带宽内提供下变频发射信号。 指定的啁啾波形可以包括第一持续时间期间的第一啁啾波形和第二持续时间内的第二啁啾波形。

公开(公告)号：US20130342835A1

公开(公告)日：2013-12-26

申请号：US13925883

申请日：2013-06-25

申请人： Jordana Blacksberg

发明人： Jordana Blacksberg

IPC分类号： G01J3/28 ,  G01J3/44

CPC分类号： G01J3/2803 ,  G01J3/2889 ,  G01J3/44

摘要： A Raman spectrometer that employs a time-gated single photon avalanche diode array as a sensor is described. The spectrometer can also perform fluorescence spectroscopy and laser induced breakdown spectroscopy (LIBS). A laser is used to provide an excitation signal to excite a specimen of interest. A spectrometer is used to separate the various intensities over a range of wavelengths, which are then caused to impinge on the array to be recorded. The time-gated single photon avalanche diode array is triggered in synchrony with the excitation signal so as to allow time resolution of the response of the sample of interest to the excitation. The array can be time-gated to resolve signals that have shorter durations as a function of time while excluding signals that have a longer time duration. Raman and LIBS signals can be observed even from specimens that fluoresce strongly.

摘要翻译： 描述了采用时间门控单光子雪崩二极管阵列作为传感器的拉曼光谱仪。 光谱仪还可以执行荧光光谱和激光诱导击穿光谱（LIBS）。 激光用于提供激发信号以激发感兴趣的标本。 使用光谱仪来分离波长范围上的各种强度，然后使其照射到要记录的阵列上。 时间门控单光子雪崩二极管阵列与激励信号同步地触发，以便允许激发样本的响应的时间分辨。 阵列可以被时间选通，以排除具有较短持续时间的信号作为时间的函数，同时排除具有较长持续时间的信号。 拉曼和LIBS信号甚至可以从荧光强的样品中观察到。

公开(公告)号：US20120223229A1

公开(公告)日：2012-09-06

申请号：US13406491

申请日：2012-02-27

申请人： Takeaki Itsuji

发明人： Takeaki Itsuji

IPC分类号： H01L27/146 ,  G01J3/28

CPC分类号： G01J3/0205 ,  G01J3/0229 ,  G01J3/2823 ,  G01J3/2889 ,  G01N21/3586

摘要： An apparatus visualizing internal information of an object includes a detection unit of terahertz wave, a generating unit of a time waveform of the terahertz wave, a modulation unit, an adjustment unit, and an addition unit. The modulation unit sequentially performs spatial modulation on a propagation distance for each pixel of a terahertz wave corresponding to a pixel in a horizontal direction by using a plurality of modulation patterns, and emits a plurality of terahertz waves. Based on a time amount converted from the change of the propagation distances corresponding to the modulation patterns, the adjustment unit adjusts a position on a time axis of the time waveforms of a plurality of terahertz waves and calculates a new plurality of time waveforms. The addition unit adds a new time waveform for each pixel. The apparatus can suppress reduction in signal intensity of a terahertz wave while maintaining detection sensitivity.

摘要翻译： 可视化对象的内部信息的装置包括太赫兹波的检测单元，太赫兹波的时间波形的生成单元，调制单元，调整单元和加法单元。 调制单元通过使用多个调制图案，顺序对与水平方向的像素对应的太赫兹波的每个像素的传播距离进行空间调制，并发射多个太赫兹波。 基于从与调制图案对应的传播距离的变化而转换的时间量，调整单元调整多个太赫兹波的时间波形的时间轴上的位置，并计算新的多个时间波形。 加法单元为每个像素添加新的时间波形。 该装置可以在保持检测灵敏度的同时抑制太赫兹波的信号强度的降低。

公开(公告)号：US20120049070A1

公开(公告)日：2012-03-01

申请号：US12862733

申请日：2010-08-24

申请人： Payam Mousavi ,  Steven Dodge ,  Frank Martin Haran ,  Stephane Savard ,  David Jez ,  Stuart James Heath

发明人： Payam Mousavi ,  Steven Dodge ,  Frank Martin Haran ,  Stephane Savard ,  David Jez ,  Stuart James Heath

IPC分类号： G01J5/54 ,  G01J3/28

CPC分类号： G01J3/42 ,  D21F7/06 ,  D21G9/0009 ,  G01B11/0625 ,  G01J3/28 ,  G01J3/2889 ,  G01N21/3559 ,  G01N21/3586 ,  G01N21/86 ,  G01N2021/8663

摘要： An apparatus for incorporation into time-domain spectroscopy systems that creates a continuous reference whereby a sample pulses' phase and amplitude can be tracked and corrected employs a beam splitter to generate sample and reference pulses. A detector is positioned for receiving the reference radiation pulses that do not interact with the sample. The same detector is also positioned for receiving the sample radiation pulses that emerge from the sample. The apparatus can be readily implemented by being configured between the emitter and detector of a terahertz time-domain spectrometer. The reference pulse is used to trace the changes in time and amplitude of the sample pulse. Since any changes in the reference pulse will most likely manifest in the sample pulse, the reference pulse is monitored and used to correct the sample pulse and thereby reduce the effects of jitter.

摘要翻译： 一种用于结合到时域光谱系统中的装置，其创建连续参考，由此可以跟踪和校正采样脉冲的相位和幅度，使用分束器来产生采样和参考脉冲。 定位检测器用于接收不与样品相互作用的参考辐射脉冲。 相同的检测器也被定位成用于接收从样品中出现的样品辐射脉冲。 该装置可以通过配置在太赫兹时域光谱仪的发射极和检测器之间来容易地实现。 参考脉冲用于跟踪采样脉冲的时间和幅度的变化。 由于参考脉冲中的任何变化将最有可能体现在采样脉冲中，所以监视参考脉冲并用于校正采样脉冲，从而减少抖动的影响。

公开(公告)号：US08059272B2

公开(公告)日：2011-11-15

申请号：US11662680

申请日：2005-09-16

申请人： Jean-Daniel Ganiere

发明人： Jean-Daniel Ganiere

IPC分类号： G01J3/28

CPC分类号： G01J3/2889 ,  G01J3/04 ,  G01J3/22

摘要： Light dispersing device comprising a slit element having a slit for exposure to electromagnetic radiation, wherein the slit element is configured and disposed for turning the slit between at least two positions. The light dispersing device is used together with a streak camera, whereby in a first position the slit is adjusted to influence the temporal resolution of the streak camera and in a second postion the slit is adjusted to influence the spectral resolution of the streak camera.

摘要翻译： 光分配装置包括具有用于暴露于电磁辐射的狭缝的狭缝元件，其中，所述狭缝元件构造和设置用于在至少两个位置之间转动狭缝。 光分散装置与条纹相机一起使用，由此在第一位置调整狭缝以影响条纹相机的时间分辨率，并且在第二位置中，调节狭缝以影响条纹相机的光谱分辨率。

公开(公告)号：US20100110441A1

公开(公告)日：2010-05-06

申请号：US12613586

申请日：2009-11-06

申请人： Jun Koshoubu

发明人： Jun Koshoubu

IPC分类号： G01J3/45

CPC分类号： G01J3/453 ,  G01J3/2889 ,  G02B21/0096

摘要： A microscope comprising: a light sampler for collecting light from a measurement area of a sample; a multi-element detector having a plurality of photoelectric elements, for detecting the light collected by the light sampler, each photoelectric element corresponding to a minute measurement region in the measurement area with one-to-one correspondence; a Fourier transform spectrophotometer as a spectroscope; a data sampler for concurrently sampling intensity data sent from each photoelectric element of the multi-element detector at a timing determined by the Fourier transform spectrophotometer; and a data processor for obtaining time-resolved spectrum data for each minute measurement region according to temporally changed interference light data obtained by the data sampler.

摘要翻译： 一种显微镜，包括：用于收集来自样品的测量区域的光的光采样器; 具有多个光电元件的多元件检测器，用于检测由光采样器收集的光，每个光电元件对应于测量区域中的微小测量区域与一一对应; 傅里叶变换分光光度计作为分光镜; 数据采样器，用于在由傅里叶变换分光光度计确定的时刻同时采样从多元素检测器的每个光电元件发送的强度数据; 以及数据处理器，用于根据由数据采样器获得的时间上改变的干涉光数据，为每个微小测量区域获得时间分辨的光谱数据。

公开(公告)号：US20100103426A1

公开(公告)日：2010-04-29

申请号：US12566403

申请日：2009-09-24

申请人： Chang-Seok Kim ,  Myung-Yung Jeong ,  Jae-Seok Park ,  Eun-Joo Jung ,  Hyung-Seok Lee

发明人： Chang-Seok Kim ,  Myung-Yung Jeong ,  Jae-Seok Park ,  Eun-Joo Jung ,  Hyung-Seok Lee

IPC分类号： G01N21/47 ,  G01J3/44

CPC分类号： G01J3/2889 ,  G01D5/35316 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/10 ,  G01J3/26 ,  G01J3/42 ,  G01J3/4338

摘要： Provided is an optical sensor interrogation system. The optical sensor interrogation system includes: a light source unit which matches round-trip time of light and wavelength tunable cycle time of light in a resonator and emits light; a sensing unit which receives an optical signal in which a center wavelength periodically tunes, from the light source unit and tunes the center wavelength of the optical signal according to physical changes applied from the outside; and a signal processing unit which receives the optical signal reflected from the sensing unit, detects data, and images the data. In particular, the light source unit includes a delaying unit which delays the round-trip time of light and a tunable filter which tunes the wavelength of light so as to match the round-trip time of light with the wavelength tunable cycle time of light. Accordingly, a Fourier domain mode locking (FDML) wavelength swept laser, which operates at speed of several tens kHz or above, is used as a light source so that strain of a fluid, which changes in a short time interval of 0.1 msec or below, is precisely measured and thus a real-time analysis may be performed at high speed.

摘要翻译： 提供了一种光学传感器询问系统。 光传感器询问系统包括：光源单元，其匹配谐振器中的光的往返时间和波长可调周期时间，并发光; 感测单元，其从光源单元接收中心波长周期性地调谐的光信号，并根据从外部施加的物理变化调谐光信号的中心波长; 以及信号处理单元，其接收从感测单元反射的光信号，检测数据并对数据进行成像。 特别地，光源单元包括延迟光的往返时间的延迟单元和调节光的波长的可调谐滤波器，以便将光的往返时间与光的波长可调周期时间相匹配。 因此，以几十kHz或更高速度运行的傅立叶域模式锁定（FDML）波长扫描激光器被用作光源，使得在0.1msec或更短的时间间隔内变化的流体应变 ，被精确测量，因此可以高速执行实时分析。

公开(公告)号：US07689269B2

公开(公告)日：2010-03-30

申请号：US11801549

申请日：2007-05-10

申请人： Marlin O. Thurston ,  Karl W. Olson

发明人： Marlin O. Thurston ,  Karl W. Olson

IPC分类号： A61B6/00 ,  A61B8/00

CPC分类号： G01J3/4406 ,  A61B5/0059 ,  A61B5/415 ,  A61B5/418 ,  G01J3/02 ,  G01J3/027 ,  G01J3/28 ,  G01J3/2889 ,  G01N21/6408 ,  G01N21/6428

摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing nanocrystal tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.

摘要翻译： 系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光纳米晶体示踪剂结合使用。 探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。 描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。