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公开(公告)号：US12032147B2
公开(公告)日：2024-07-09
申请号：US17255808
申请日：2018-10-01
发明人： Fausto D'Apuzzo , Viktor Shkolnikov
IPC分类号： G02B21/12 , G01N15/0227 , G01N15/10 , G01N15/14 , G01N15/1433 , G01N15/1434 , G02B21/00 , G02B21/36
CPC分类号： G02B21/12 , G01N15/0227 , G01N15/1433 , G01N15/1434 , G01N15/1459 , G02B21/0004 , G02B21/36 , G01N2015/1006 , G01N2015/1493
摘要： A system and a method for imaging microfluidic ejectors during operation. An example provides a microscopy system, that includes a plurality of microfluidic ejectors. A mirror is disposed in a droplet path of the plurality of microfluidic ejectors, wherein the droplet path passes through an opening in the mirror. An optical system is focused on the plurality of microfluidic ejectors through the mirror, wherein the optical system comprises a camera.
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公开(公告)号：US11815671B2
公开(公告)日：2023-11-14
申请号：US17012189
申请日：2020-09-04
发明人： Jason G. Valentine , You Zhou , Hanyu Zheng
摘要： A 2D spatial differentiator operates in transmission and comprises a Si nanorod photonic crystal that can transform an image, Ein, into its second-order derivative, Eout α ∇2 Ein, allowing for direct discrimination of the edges in the image. The use of a 2D photonic crystal allows for differentiation and edge detection in all directions with a numerical aperture (NA) up to 0.315 and an experimental resolution smaller than 4 μm. The nanophotonic differentiator is able to be directly integrated into an optical microscope and onto a camera sensor, demonstrating the ease with which it can be vertically integrated into existing imaging systems. Furthermore, integration with a metalens is demonstrated for realizing a compact and monolithic image-processing system. In all cases, the use of the nanophotonic differentiator allows for a significant reduction in size compared to traditional systems, opening new doors for optical analog image processing in applications involving computer vision.
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公开(公告)号：US20230236409A1
公开(公告)日：2023-07-27
申请号：US18193946
申请日：2023-03-31
申请人： OPTOFLUIDICS, INC.
发明人： Colby Ashcroft , Brian DiPaolo , Gjergji Konica , Thomas Castner , Bernardo Cordovez , Christopher Earhart , David Erickson , Robert Hart
IPC分类号： G02B21/36 , G01N15/02 , G01N15/14 , G02B21/12 , G02B21/24 , G01N21/64 , G02B21/16 , G01N15/00 , G01N21/35 , G01N21/65 , G01N15/10
CPC分类号： G02B21/367 , G01N15/0272 , G01N15/147 , G02B21/12 , G01N15/1429 , G02B21/24 , G01N15/1425 , G01N15/1475 , G01N15/1434 , G01N21/6456 , G02B21/16 , G01N15/1436 , G01N15/0227 , G01N15/1463 , G01N2015/0011 , G01N2021/3595 , G01N21/65 , G01N2015/1006 , G01N2015/1493 , G01N2015/1497 , G01N2201/062 , G01N2015/0065 , G01N2015/0053 , G01N2015/0294 , G01N21/6452 , G01N2015/003
摘要： A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.
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公开(公告)号：US09510754B2
公开(公告)日：2016-12-06
申请号：US14747829
申请日：2015-06-23
发明人： Peter Reimer , Juergen Liegel , Markus Bausewein
CPC分类号： A61B3/14 , A61B3/13 , G02B19/0066 , G02B21/082 , G02B21/12
摘要： An illumination arrangement includes illumination optics defining an optical axis and a light source for generating at least one illumination beam path for illuminating an object field at a specific illumination angle with a viewing beam path. At least one mirror is provided in the illumination beam path for deflecting light from the light source and the mirror has a longitudinal extent along the optical axis. A light-emitting surface region of the light source is variable (x) perpendicular to the optical axis without movable components. The illumination optics are embodied in such a way for obtaining a desired illumination that an illumination pupil is imaged within the longitudinal extent of the mirror.
摘要翻译： 照明装置包括限定光轴的照明光学器件和用于产生用于以与观察光束路径以特定照明角度照射物场的至少一个照明光束路径的光源。 在照明光束路径中设置至少一个反射镜，用于偏转来自光源的光，并且反射镜具有沿光轴的纵向延伸。 光源的发光表面区域是垂直于光轴的变量（x），不具有可移动部件。 照明光学器件以这样的方式实现，以获得照明光瞳在镜的纵向范围内成像的期望照明。
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公开(公告)号：US20160091706A1
公开(公告)日：2016-03-31
申请号：US14502586
申请日：2014-09-30
发明人： Varun Raghunathan
CPC分类号： G02B21/365 , G02B21/06 , G02B21/12 , G02B21/14
摘要： A light field representation of a sample is synthesized or simulated based on bright field image data and phase image data acquired by a microscope such as a quantitative phase microscope. The light field representation may be utilized to render three-dimensional representations of the sample.
摘要翻译： 基于通过诸如定量相位显微镜的显微镜获得的亮场图像数据和相位图像数据来合成或模拟样本的光场表示。 光场表示可以用于渲染样本的三维表示。
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公开(公告)号：US20150374234A1
公开(公告)日：2015-12-31
申请号：US14747829
申请日：2015-06-23
发明人： Peter Reimer , Juergen Liegel , Markus Bausewein
CPC分类号： A61B3/14 , A61B3/13 , G02B19/0066 , G02B21/082 , G02B21/12
摘要： An illumination arrangement includes illumination optics defining an optical axis and a light source for generating at least one illumination beam path for illuminating an object field at a specific illumination angle with a viewing beam path. At least one mirror is provided in the illumination beam path for deflecting light from the light source and the mirror has a longitudinal extent along the optical axis. A light-emitting surface region of the light source is variable (x) perpendicular to the optical axis without movable components. The illumination optics are embodied in such a way for obtaining a desired illumination that an illumination pupil is imaged within the longitudinal extent of the mirror.
摘要翻译： 照明装置包括限定光轴的照明光学器件和用于产生用于以与观察光束路径以特定照明角度照射物场的至少一个照明光束路径的光源。 在照明光束路径中设置至少一个反射镜，用于偏转来自光源的光，并且反射镜具有沿光轴的纵向延伸。 光源的发光表面区域是垂直于光轴的变量（x），不具有可移动部件。 照明光学器件以这样的方式实现，以获得照明光瞳在镜的纵向范围内成像的期望照明。
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公开(公告)号：US09215425B1
公开(公告)日：2015-12-15
申请号：US13758912
申请日：2013-02-04
申请人： Colin Farrell , Jan van Burken
发明人： Colin Farrell , Jan van Burken
IPC分类号： H04N7/18
CPC分类号： G01B11/24 , G01B9/04 , G02B21/006 , G02B21/008 , G02B21/12
摘要： A side camera is combined with a conventional optical metrology system to image the object during the focusing scan performed in normal focusing procedures. The camera is positioned in fixed spatial relation to the objective and with its focal plane in substantial alignment with the optical axis of the objective so as to image the object during the scan. The camera is used to monitor the illumination spot formed on the object by the beam projected through the system's objective. The in-focus position is found by moving the object such that the illumination spot coincides with the objective's focus seen through the camera.
摘要翻译： 侧面照相机与传统的光学测量系统组合，以在正常对焦过程中执行的聚焦扫描期间对物体进行成像。 照相机以与物体固定的空间关系定位并且其焦平面与物镜的光轴基本对准，以便在扫描期间对物体进行成像。 相机用于通过通过系统目标投影的光束来监视形成在物体上的照明点。 通过移动对象来发现对焦位置，使得照明点与通过照相机观察到的物体的焦点重合。
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8.发明申请SLIDE SCANNER WITH DYNAMIC FOCUS AND SPECIMEN TILT AND METHOD OF OPERATION 有权具有动态聚焦和样本倾斜的滑动扫描仪及其操作方法公开(公告)号：US20150054921A1
公开(公告)日：2015-02-26
申请号：US14387457
申请日：2013-03-21
CPC分类号： G02B21/365 , G02B21/006 , G02B21/0076 , G02B21/008 , G02B21/12 , G02B21/16 , G02B21/26
摘要： An instrument and method for scanning large microscope specimen on a specimen holder has a scanning optical microscope that is configured to scan the specimen in one of brightfield and fluorescence. The specimen is dynamically tillable about a scan direction during a scan to maintain focus along the length of each scan line as the scan proceeds. A three dimensional image of the specimen can be obtained wherein the specimen tilt and relative focus are maintained from a first image contour to a second image contour through a thickness of a specimen.
摘要翻译： 用于扫描样本支架上的大显微镜样本的仪器和方法具有扫描光学显微镜，其配置为以明场和荧光之一扫描样本。 在扫描过程中，样本可以围绕扫描方向动态切割，以便在扫描进行时沿着每条扫描线的长度保持对焦。 可以获得样本的三维图像，其中样本倾斜和相对聚焦通过样本的厚度从第一图像轮廓维持到第二图像轮廓。
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9.发明申请Pathology Slide Scanners For Fluorescence And Brightfield Imaging And Method Of Operation 有权病理幻灯片扫描仪用于荧光和亮点成像和操作方法公开(公告)号：US20130342674A1
公开(公告)日：2013-12-26
申请号：US13730488
申请日：2012-12-28
申请人： Arthur Edward Dixon
发明人： Arthur Edward Dixon
IPC分类号： G02B21/36
CPC分类号： G02B21/36 , G01N21/6458 , G02B5/201 , G02B21/0076 , G02B21/12 , G02B21/367
摘要： An instrument for scanning a specimen has a two-dimensional sensor array, the sensor array containing a mosaic colour filter array or a scanning colour filter array. The instrument can be operated in fluorescence or in brightfield. The scanning colour filter array has the same colour throughout each row with adjacent rows having different colours.
摘要翻译： 用于扫描样本的仪器具有二维传感器阵列，该传感器阵列包含马赛克滤色器阵列或扫描滤色器阵列。 仪器可以在荧光灯或明场上操作。 扫描滤色器阵列在每行中具有相同的颜色，相邻行具有不同的颜色。
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公开(公告)号：US07564623B2
公开(公告)日：2009-07-21
申请号：US11106819
申请日：2005-04-15
摘要： An illumination system for a microscope, including a light source for generating light to illuminate a sample for microscopic observation, at least one collimating lens for collimating light generated by the light source, and a darkfield condenser for receiving collimated light and directing a hollow cone of light onto the sample under observation. The system optionally includes an adapter for enhancing economy of light transmission from the light source to the specimen, the adapter having a centrally disposed spacer and a plurality of optical fibers surrounding the spacer, to generate a hollow cylinder of light for transmission to the darkfield condenser. The system provides improved resolution and contrast, and is well suited for adaptation to fluorescence microscopy techniques.
摘要翻译： 一种用于显微镜的照明系统，包括用于产生用于照明用于显微镜观察的样品的光的光源，至少一个用于准直光源产生的光的准直透镜，以及用于接收准直光的暗场冷凝器， 在观察下点亮样品。 该系统可选地包括用于增强从光源到样本的光透射的经济性的适配器，适配器具有居中设置的隔离物和围绕间隔物的多个光纤，以产生中空的圆筒，用于传输到暗场冷凝器 。 该系统提供改进的分辨率和对比度，并且非常适合于适应荧光显微镜技术。
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