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1.发明授权Pathology slide scanners for fluorescence and brightfield imaging and method of operation 有权病理幻灯片扫描仪用于荧光和明场成像及手术方法公开(公告)号：US09575304B2
公开(公告)日：2017-02-21
申请号：US13730488
申请日：2012-12-28
申请人： Arthur Edward Dixon
发明人： Arthur Edward Dixon
CPC分类号： G02B21/36 , G01N21/6458 , G02B5/201 , G02B21/0076 , G02B21/12 , G02B21/367
摘要： An instrument for scanning a specimen has a two-dimensional sensor array, the sensor array containing a mosaic color filter array or a scanning color filter array. The instrument can be operated in fluorescence or in brightfield. The scanning color filter array has the same color throughout each row with adjacent rows having different colors.
摘要翻译： 用于扫描样本的仪器具有二维传感器阵列，该传感器阵列包含马赛克滤色器阵列或扫描滤色器阵列。 仪器可以在荧光灯或明场上操作。 扫描滤色器阵列在每行中具有相同的颜色，相邻行具有不同的颜色。
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公开(公告)号：US08896918B2
公开(公告)日：2014-11-25
申请号：US13699251
申请日：2011-12-23
申请人： Arthur Edward Dixon
发明人： Arthur Edward Dixon
CPC分类号： G02B21/06 , G02B21/002 , G02B21/367
摘要： An instrument and method for scanning at least a portion of a large specimen preferably causes the specimen to move relative to a two-dimensional detector array at a constant speed. The detector array takes one image of the specimen for each line that the detector moves. A controller controls a shutter of the detector array to open to take images and to pass the images to a processor, which is preferably a computer. The instrument takes one partial image of each part of the specimen that is being scanned and then combines those images with other images to produce a contiguous image.
摘要翻译： 用于扫描大样本的至少一部分的仪器和方法优选地使样本相对于二维检测器阵列以恒定速度移动。 检测器阵列为检测器移动的每条线取一个样本图像。 控制器控制检测器阵列的快门打开以拍摄图像并将图像传送到优选地是计算机的处理器。 仪器采集被扫描样本的每个部分的一部分图像，然后将这些图像与其他图像组合以产生连续的图像。
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3.发明申请Pathology Slide Scanners For Fluorescence And Brightfield Imaging And Method Of Operation 有权病理幻灯片扫描仪用于荧光和亮点成像和操作方法公开(公告)号：US20130342674A1
公开(公告)日：2013-12-26
申请号：US13730488
申请日：2012-12-28
申请人： Arthur Edward Dixon
发明人： Arthur Edward Dixon
IPC分类号： G02B21/36
CPC分类号： G02B21/36 , G01N21/6458 , G02B5/201 , G02B21/0076 , G02B21/12 , G02B21/367
摘要： An instrument for scanning a specimen has a two-dimensional sensor array, the sensor array containing a mosaic colour filter array or a scanning colour filter array. The instrument can be operated in fluorescence or in brightfield. The scanning colour filter array has the same colour throughout each row with adjacent rows having different colours.
摘要翻译： 用于扫描样本的仪器具有二维传感器阵列，该传感器阵列包含马赛克滤色器阵列或扫描滤色器阵列。 仪器可以在荧光灯或明场上操作。 扫描滤色器阵列在每行中具有相同的颜色，相邻行具有不同的颜色。
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公开(公告)号：US06243189B1
公开(公告)日：2001-06-05
申请号：US09294308
申请日：1999-04-20
IPC分类号： G02B2608
CPC分类号： G02B13/0095 , G02B21/0036 , G02B21/0072 , G02B23/00 , G02B26/105
摘要： The present invention provides an inexpensive, simple, compact, optical relay for use primarily with scanning beam imaging systems. More specifically, it can be used as an optical interconnect between scanning mirrors and between a scanning mirror and imaging optics such as a microscope objective. The optical relay, also known as an optical telescope or coupler, consists of two eyepieces forming an afocal assembly. A beam pivoting about a stationary point in the first focal plane of the first eyepiece will be relayed through the optical system such that it pivots about a stationary point at the second focal plane of the second eyepiece. In the preferred embodiment a collimated beam pivots about the first focal point of the first eyepiece as it enters the optical relay, and exits the optical relay with the same beam diameter and scan angle (opposite sign) pivoting about the second focal point of the second eyepiece.
摘要翻译： 本发明提供了一种廉价，简单，紧凑的光学继电器，主要用于扫描光束成像系统。 更具体地，其可以用作扫描反射镜之间以及扫描反射镜和诸如显微镜物镜的成像光学器件之间的光学互连。 光学继电器，也称为光学望远镜或耦合器，由形成无焦点组件的两个目镜组成。 围绕第一目镜的第一焦平面中的静止点枢转的光束将通过光学系统中继，使得其绕第二目镜的第二焦平面处的静止点枢转。 在优选实施例中，准直束在其进入光学继电器时围绕第一目镜的第一焦点枢转，并且以相同的光束直径和相对于第二目标的第二焦点枢转的扫描角度（相反的符号）离开光学继电器 目镜。
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公开(公告)号：US20130155499A1
公开(公告)日：2013-06-20
申请号：US13699251
申请日：2011-12-23
申请人： Arthur Edward Dixon
发明人： Arthur Edward Dixon
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/002 , G02B21/367
摘要： An instrument and method for scanning at least a portion of a large specimen preferably causes the specimen to move relative to a two-dimensional detector array at a constant speed. The detector array takes one image of the specimen for each line that the detector moves. A controller controls a shutter of the detector array to open to take images and to pass the images to a processor, which is preferably a computer. The instrument takes one partial image of each part of the specimen that is being scanned and then combines those images with other images to produce a contiguous image.
摘要翻译： 用于扫描大样本的至少一部分的仪器和方法优选地使样本相对于二维检测器阵列以恒定速度移动。 检测器阵列为检测器移动的每条线取一个样本图像。 控制器控制检测器阵列的快门打开以拍摄图像并将图像传送到优选地是计算机的处理器。 仪器采集被扫描样本的每个部分的一部分图像，然后将这些图像与其他图像组合以产生连续的图像。
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公开(公告)号：US20130015370A1
公开(公告)日：2013-01-17
申请号：US13550291
申请日：2012-07-16
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N2021/6421 , G01N2021/6439 , G01N2201/10 , G01N2201/1042
摘要： An instrument and method for scanning a large specimen supported on a specimen holder has a plurality of illumination sources with each illumination, source being focused on a different focus spot of the specimen simultaneously. There are a plurality of spectrally resolved detectors to receive light reflected or emitted from the different focus spots simultaneously with each spectrally resolved detector receiving light from one illumination source only.
摘要翻译： 用于扫描支撑在样本保持器上的大样本的仪器和方法具有多个照明源，每个照明源同时聚焦在样本的不同聚焦点上。 存在多个光谱分辨检测器，用于接收来自不同焦点的反射或发射的光，同时每个光谱分辨检测器仅接收来自一个照明源的光。
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公开(公告)号：US10823952B2
公开(公告)日：2020-11-03
申请号：US16015853
申请日：2018-06-22
申请人： Arthur Edward Dixon
发明人： Arthur Edward Dixon
摘要： An instrument for scanning a specimen on a specimen holder. The instrument includes a scanning stage for supporting the specimen and a detector having a plurality of pixels. The scanning stage and the detector are movable relative to each other to move the specimen in a scan direction during a scan, and at least some of the pixels of the detector are operable to collect light inside the specimen during the scan and generate corresponding image data. The instrument also includes a processor operable to perform MSIA on the image data and to generate two or more strip images. Each strip image has a different effective exposure. The processor combines the two or more strip images to generate an increased dynamic range (IDR) image of the specimen.
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公开(公告)号：US20180373017A1
公开(公告)日：2018-12-27
申请号：US16015853
申请日：2018-06-22
申请人： Arthur Edward Dixon
发明人： Arthur Edward Dixon
摘要： An instrument for scanning a specimen on a specimen holder. The instrument includes a scanning stage for supporting the specimen and a detector having a plurality of pixels. The scanning stage and the detector are movable relative to each other to move the specimen in a scan direction during a scan, and at least some of the pixels of the detector are operable to collect light inside the specimen during the scan and generate corresponding image data. The instrument also includes a processor operable to perform MSIA on the image data and to generate two or more strip images. Each strip image has a different effective exposure. The processor combines the two or more strip images to generate an increased dynamic range (IDR) image of the specimen.
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9.发明授权
公开(公告)号：US5760951A
公开(公告)日：1998-06-02
申请号：US113191
申请日：1993-08-30
CPC分类号： G02B21/002 , G02B21/0056 , G02B21/0068 , G02B21/0076 , G02B26/101
摘要： A confocal scanning beam optical imaging or mapping system for macroscopic samples is disclosed, in which an expanded laser beam passes through a scan system and a telecentric laser scan lens focuses the beam to a moving spot in the sample. Light reflected (or emitted) from the illuminated spot is collected by the laser scan lens, descanned by the scan system, and detected by a confocal detector. Confocal transmitted-light and non-confocal versions are also disclosed. This new scanning beam laser imaging system performs a rapid scan of a large sample with optical image slicing capability (using the confocal detector). Applications include fluorescent imaging of large biomedical specimens, including fluorescent gels, photoluminescence mapping of semiconductor samples, etc.
摘要翻译： 公开了一种用于宏观样本的共聚焦扫描光束成像或映射系统，其中扩展的激光束通过扫描系统，而远心激光扫描透镜将光束聚焦到样品中的移动点。 来自照明光点的光反射（或发射）由扫描系统扫描并由共聚焦探测器检测。 共聚焦透射和非共焦型也被公开。 这种新的扫描光束激光成像系统利用光学图像切片能力（使用共焦检测器）对大样本进行快速扫描。 应用包括大型生物医学标本的荧光成像，包括荧光凝胶，半导体样品的光致发光映射等。
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