公开(公告)号：US12127789B2

公开(公告)日：2024-10-29

申请号：US18202725

申请日：2023-05-26

申请人： TIANJIN EYE HOSPITAL ,  WENZHOU UNIVERSITY OF TECHNOLOGY

发明人： Yan Wang ,  Xuan Chen ,  Zuoping Tan ,  Riwei Wang

IPC分类号： A61B3/10 ,  A61B3/00 ,  A61B3/02 ,  A61B3/107 ,  A61B3/14

CPC分类号： A61B3/107 ,  A61B3/0025 ,  A61B3/145

摘要： The present disclosure relates to a subtle cornea deformation identification method and device based on a pixel-level corneal biomechanical parameter, including the following steps: step 1, sampling and analyzing a dynamic video of corneal stress deformation in a historical database, and calculating pixel-level data; and step 2, configuring an ensemble classifier based on a sampling result and detecting a local change in corneal biomechanics, thus identifying a subtle cornea deformation. The present disclosure has high measurement accuracy and is capable of detecting a local subtle biomechanical change.

公开(公告)号：US20240350002A1

公开(公告)日：2024-10-24

申请号：US18421592

申请日：2024-01-24

申请人： DeepEyeVision Inc.

发明人： Siamak Yousefi ,  Hidenori Takahashi ,  Hazem Abdelmotaal ,  Rossen Mihaylov Hazarbassanov ,  Ali H. Al-Timemy ,  Alexandru Lavric

IPC分类号： A61B3/10 ,  A61B3/00 ,  A61B3/14 ,  G06T7/00 ,  G16H50/20

CPC分类号： A61B3/101 ,  A61B3/0025 ,  A61B3/14 ,  G06T7/0016 ,  G16H50/20 ,  G06T2207/10016 ,  G06T2207/20021 ,  G06T2207/20081 ,  G06T2207/30041

摘要： An ophthalmic system includes an acquiring unit which acquires a moving image of a subject's eye captured by an imaging apparatus that opposes a subject, an analyzing unit which specifies an analysis object region in the subject's eye based on the moving image and which analyzes a spatial and/or temporal distribution of information related to characteristics of a surface of the subject's eye in the analysis object region, an assessing unit which assesses a possibility of the subject's eye being affected by a predetermined ophthalmic disease based on the distribution of information related to the characteristics and which generates a classification result of classifying the subject's eye into a predetermined classification group related to the affection of the ophthalmic disease in accordance with a degree of the possibility, and a diagnosis support information generating unit which generates diagnosis support information.

公开(公告)号：US20240341594A1

公开(公告)日：2024-10-17

申请号：US18633987

申请日：2024-04-12

申请人： Alcon Inc.

发明人： Zsolt Bor

IPC分类号： A61B3/12 ,  A61B3/00 ,  A61B3/10 ,  A61B3/14

CPC分类号： A61B3/12 ,  A61B3/0058 ,  A61B3/0091 ,  A61B3/1025 ,  A61B3/145

摘要： Particular embodiments disclosed herein include projecting an orientation grid into an eye of a patient. A computer system captures one or more images of a retina of an eye of the patient, such as using an SLO, while projecting the orientation grid into the eye of the patient. A fixation grid may also be displayed with the patient being instructed to fixate on the fixation target. The computer system superimposes the orientation grid onto the one or more images to obtain one or more output images. The one or more output images are displayed to at least one of a surgeon and the patient. The surgeon and/or patient may review the output images and communicate the location of floaters using coordinates of the orientation grid.

公开(公告)号：US12117675B2

公开(公告)日：2024-10-15

申请号：US18337249

申请日：2023-06-19

申请人： Magic Leap, Inc.

发明人： John Graham Macnamara ,  Nicole Elizabeth Samec ,  Nastasja U. Robaina ,  Eric Baerenrodt ,  Christopher M. Harrises

IPC分类号： G02C7/02 ,  A61B3/00 ,  A61B3/028 ,  A61B3/10 ,  A61B3/13 ,  A61B3/14 ,  G02B27/01 ,  G02C11/00 ,  G06F1/14 ,  G06F1/16 ,  G06F3/01 ,  G06T13/40

CPC分类号： G02C7/027 ,  A61B3/00 ,  A61B3/0025 ,  A61B3/028 ,  A61B3/1015 ,  A61B3/13 ,  A61B3/14 ,  G02B27/017 ,  G02B27/0172 ,  G02C11/10 ,  G06F1/14 ,  G06F1/163 ,  G06F3/011 ,  G06F3/013 ,  G06T13/40 ,  G02B2027/011 ,  G02B2027/0132 ,  G02B2027/0138 ,  G02B2027/014 ,  G02B2027/0178 ,  G02B2027/0181 ,  G02C2202/22

摘要： A wearable ophthalmic device is disclosed. The device may include a head-mounted light field display configured to generate a physical light field comprising a beam of light. The head-mounted light field display may direct the beam of light into a user's eye, thereby producing a retinal reflex. The device may also include a head-mounted photodetector array configured to receive the retinal reflex and to generate numerical image data. The device may also include a light field processor configured to control the light field display, to analyze the retinal reflex using the numerical image data, and to determine an optical prescription for the user's eye based on the analysis of the retinal reflex.

公开(公告)号：US20240339191A1

公开(公告)日：2024-10-10

申请号：US18744107

申请日：2024-06-14

申请人： Genentech, Inc. ,  Hoffmann-La Roche Inc.

发明人： Yusuke Alexander KIKUCHI ,  Ales NEUBERT ,  Carlos Quezada RUIZ ,  Jian DAI

IPC分类号： G16H20/17 ,  A61B3/00 ,  A61B3/10 ,  A61B3/12 ,  G16H50/30

CPC分类号： G16H20/17 ,  A61B3/0025 ,  A61B3/102 ,  A61B3/1225 ,  G16H50/30

摘要： A method and system for predicting a selected treatment regimen for a subject. Baseline data for a subject diagnosed with neovascular age-related macular degeneration (nAMD) is received. A plurality of predictor inputs is formed for an outcome predictor using the baseline data and regimen data for a plurality of treatment regimens. The plurality of predictor inputs comprises a different predictor input for each of the plurality of treatment regimens. A plurality of treatment scores is generated for the plurality of treatment regimens via the set of outcome predictor using the plurality of predictor inputs. One of the plurality of treatment regimens is selected as a selected treatment regimen for the subject based on the plurality of treatment scores.

公开(公告)号：US20240335108A1

公开(公告)日：2024-10-10

申请号：US18738229

申请日：2024-06-10

申请人： Avedro, Inc.

发明人： Desmond Christopher Adler ,  Jun A. Zhang ,  Mikhail Z. Smirnov ,  Marc D. Friedman ,  David Usher ,  Grace Elizabeth Lytle ,  David C. Iannetta

IPC分类号： A61B3/107 ,  A61B3/10 ,  A61B3/14 ,  A61B5/00 ,  A61F9/007 ,  A61F9/008 ,  A61N5/06

CPC分类号： A61B3/107 ,  A61B3/10 ,  A61B3/14 ,  A61B5/0036 ,  A61F9/0079 ,  A61N5/062 ,  A61B5/0071 ,  A61B5/4848 ,  A61F2009/00872 ,  A61N2005/0661

摘要： In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.

公开(公告)号：US20240324875A1

公开(公告)日：2024-10-03

申请号：US18737811

申请日：2024-06-07

申请人： Digital Diagnostics Inc.

发明人： Michael D. Abramoff ,  Edward DeHoog

IPC分类号： A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B3/14 ,  G01B9/02 ,  G01B9/02015 ,  G01B9/02091 ,  G01J3/45

CPC分类号： A61B3/102 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/1005 ,  A61B3/1225 ,  A61B3/14 ,  G01B9/02027 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02091 ,  G01J3/45 ,  G01B2290/65

摘要： Provided is a snapshot spectral domain optical coherence tomographer comprising a light source providing a plurality of beamlets; a beam splitter, splitting the plurality of beamlets into a reference arm and a sample arm; a first optical system that projects the sample arm onto multiple locations of a sample; a second optical system for collection of a plurality of reflected sample beamlets; a third optical system projecting the reference arm to a reflecting surface and receiving a plurality of reflected reference beamlets; a parallel interferometer that provides a plurality of interferograms from each of the plurality of sample beamlets with each of the plurality of reference beamlets; an optical image mapper configured to spatially separate the plurality of interferograms; a spectrometer configured to disperse each of the interferograms into its respective spectral components and project each interferogram in parallel; and a photodetector providing photon quantification.

公开(公告)号：US20240295752A1

公开(公告)日：2024-09-05

申请号：US18403026

申请日：2024-01-03

申请人： The Medical College of Wisconsin, Inc.

发明人： Jay Neitz ,  Maureen Neitz

IPC分类号： G02C7/04 ,  A61B3/10 ,  A61B5/107 ,  A61K9/00 ,  G02C7/02 ,  G02C7/06 ,  G02C7/10 ,  G02C7/16

CPC分类号： G02C7/04 ,  A61K9/0048 ,  G02C7/02 ,  G02C7/061 ,  G02C7/10 ,  G02C7/16 ,  A61B3/1005 ,  A61B5/107 ,  G02C2202/24

摘要： Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.

公开(公告)号：US20240293023A1

公开(公告)日：2024-09-05

申请号：US18573035

申请日：2021-06-24

申请人： NIKON CORPORATION

发明人： Yongbo LI

IPC分类号： A61B3/10

CPC分类号： A61B3/102

摘要： An OCT signal processing method of a processor performing processing on a detection signal obtained by separating light emitted from a light source into measurement light and reference light, guiding the measurement light to an eye to be examined using an object optical system, guiding the reference light to a reference optical system, followed by photo-detecting interference light resulting from measurement light reflected from the eye to be examined interfering with the reference light. The OCT signal processing method includes a step of generating an OCT signal by performing Fourier transformation on the detection signal, a step of detecting a peak portion in the OCT signal, and a step of generating a first corrected OCT signal by removing the peak portion from the OCT signal.

公开(公告)号：US20240293021A1

公开(公告)日：2024-09-05

申请号：US18658154

申请日：2024-05-08

申请人： Tufts Medical Center, Inc. ,  President and Fellows of Harvard College

发明人： Pedram HAMRAH ,  Neslihan Dilruba Koseoglu ,  Andrew L. Beam

IPC分类号： A61B3/00 ,  A61B3/10 ,  A61B3/13 ,  A61B3/14 ,  G06T7/00

CPC分类号： A61B3/0025 ,  A61B3/1025 ,  A61B3/13 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/20084 ,  G06T2207/30041

摘要： The invention provides methods of diagnosing neuropathic corneal pain by the detection of neuromas, such as micro-neuromas, on the cornea. The invention also features systems for detecting the presence of anatomical features located on an ocular tissue surface that may be a marker for neuropathic corneal pain. The systems feature an in vivo confocal microscope and a computer programmed with a neural network to automate the analysis of the microscope images. The invention provides methods of using the system to identify a micro-neuroma in images collected of an ocular surface and methods of diagnosing neuropathic corneal pain and monitoring treatment of neuropathic corneal pain using a system of the invention. The invention further provides a non-transitory computer readable medium having instructions stored thereon, wherein the instructions, when executed by a processor, perform a method for automatically determining the presence of at least one neuroma on a plurality of images of an ocular surface of a patient.