公开(公告)号：US12186469B2

公开(公告)日：2025-01-07

申请号：US18455444

申请日：2023-08-24

Applicant: Tufts Medical Center, Inc.

Inventor： Navin K. Kapur

IPC: A61M1/36 ,  A61M25/00

Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.

公开(公告)号：US20240390359A1

公开(公告)日：2024-11-28

申请号：US18640657

申请日：2024-04-19

Applicant: 60 DEGREES PHARMACEUTICALS LLC ,  Tufts Medical Center, Inc.

Inventor： Geoffrey S. DOW ,  Bryan L. Smith ,  Edouard Vannier

IPC: A61K31/4706 ,  A61K31/122 ,  A61K31/65 ,  A61K31/7052 ,  A61P33/02

Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.

公开(公告)号：US12091466B2

公开(公告)日：2024-09-17

申请号：US16986214

申请日：2020-08-05

Applicant: Janssen Biotech, Inc. ,  Tufts Medical Center, Inc.

Inventor： Chakra Chaulagain ,  Raymond Comenzo ,  Parul Doshi ,  Xun Ma ,  Amy Sasser

IPC: C07K16/28 ,  A61K9/00 ,  A61K31/573 ,  A61K31/664 ,  A61K31/69 ,  A61K38/05 ,  A61K38/47 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K9/0019 ,  A61K31/573 ,  A61K31/664 ,  A61K31/69 ,  A61K38/05 ,  A61K38/47 ,  A61K39/3955 ,  A61K45/06 ,  C12Y302/01035 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732

Abstract: The present invention relates to methods of treatment of light chain amyloidosis and other CD38-positive hematological malignancies with anti-CD38 antibodies.

公开(公告)号：US20240293021A1

公开(公告)日：2024-09-05

申请号：US18658154

申请日：2024-05-08

Applicant: Tufts Medical Center, Inc. ,  President and Fellows of Harvard College

Inventor： Pedram HAMRAH ,  Neslihan Dilruba Koseoglu ,  Andrew L. Beam

IPC: A61B3/00 ,  A61B3/10 ,  A61B3/13 ,  A61B3/14 ,  G06T7/00

CPC classification number: A61B3/0025 ,  A61B3/1025 ,  A61B3/13 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/20084 ,  G06T2207/30041

Abstract: The invention provides methods of diagnosing neuropathic corneal pain by the detection of neuromas, such as micro-neuromas, on the cornea. The invention also features systems for detecting the presence of anatomical features located on an ocular tissue surface that may be a marker for neuropathic corneal pain. The systems feature an in vivo confocal microscope and a computer programmed with a neural network to automate the analysis of the microscope images. The invention provides methods of using the system to identify a micro-neuroma in images collected of an ocular surface and methods of diagnosing neuropathic corneal pain and monitoring treatment of neuropathic corneal pain using a system of the invention. The invention further provides a non-transitory computer readable medium having instructions stored thereon, wherein the instructions, when executed by a processor, perform a method for automatically determining the presence of at least one neuroma on a plurality of images of an ocular surface of a patient.

公开(公告)号：US11872361B2

公开(公告)日：2024-01-16

申请号：US16953220

申请日：2020-11-19

Applicant: Tufts Medical Center, Inc.

Inventor： Navin K. Kapur ,  Richard H. Karas

IPC: A61M25/10 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/026 ,  A61B17/12 ,  A61M60/40 ,  A61M60/135 ,  A61M60/268 ,  A61M60/871 ,  A61M60/515 ,  A61B5/29 ,  A61B17/00

CPC classification number: A61M25/10184 ,  A61B5/026 ,  A61B5/0215 ,  A61B5/02438 ,  A61B5/29 ,  A61B5/6853 ,  A61B5/6858 ,  A61B5/746 ,  A61B17/1204 ,  A61B17/12036 ,  A61B17/12109 ,  A61B17/12136 ,  A61M60/135 ,  A61M60/268 ,  A61M60/40 ,  A61M60/515 ,  A61M60/871 ,  A61B17/12172 ,  A61B2017/00022 ,  A61B2017/00044 ,  A61B2017/00115 ,  A61B2017/00154 ,  A61B2017/00199 ,  A61B2017/00221 ,  A61B2017/00398 ,  A61B2017/00411 ,  A61B2017/00734 ,  A61B2017/00889 ,  A61M25/10188 ,  A61M2025/1052 ,  A61M2205/3331 ,  A61M2230/005 ,  A61M2230/30

Abstract: Systems and methods are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient's superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient's Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The system may include sensors to determine the degree of occlusion of the superior vena cava. The occlusion system may be used to reduce volume in a heart and facilitate a cardiac procedure. The occlusion system may be used to relieve an overloaded chamber during and/or after deploying a VAD.

公开(公告)号：US11738131B2

公开(公告)日：2023-08-29

申请号：US18151982

申请日：2023-01-09

Applicant: Tufts Medical Center, Inc.

Inventor： Navin K. Kapur

IPC: A61M1/36 ,  A61M25/00

CPC classification number: A61M1/3613 ,  A61M1/3659 ,  A61M2025/0024 ,  A61M2210/127

Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.

公开(公告)号：US11624068B2

公开(公告)日：2023-04-11

申请号：US16317446

申请日：2017-07-14

Applicant: Tufts Medical Center, Inc.

Inventor： Richard P. Junghans ,  Mumtaz Yaseen

IPC: C12N15/11 ,  C12N15/113 ,  A61P31/00 ,  A61P35/00 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/706 ,  A61K31/713 ,  A61K35/17 ,  C12N9/10 ,  A61P37/04 ,  A61K31/7088 ,  A61K31/7105 ,  C07K14/47 ,  A61K45/06

Abstract: Provided herein are compositions and methods for improving immune system function. In particular, provided herein are compositions, methods, and uses of YY1 and EZH2 inhibitors for preventing and reversing T-cell exhaustion (e.g., for use in immunotherapy).

公开(公告)号：US11584934B2

公开(公告)日：2023-02-21

申请号：US16317446

申请日：2017-07-14

Applicant: Tufts Medical Center, Inc.

Inventor： Richard P. Junghans ,  Mumtaz Yaseen

IPC: C12N15/11 ,  C12N15/113 ,  A61P31/00 ,  A61P35/00 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/706 ,  A61K31/713 ,  A61K35/17 ,  C12N9/10 ,  A61P37/04 ,  A61K31/7088 ,  A61K31/7105 ,  C07K14/47 ,  A61K45/06

Abstract: Provided herein are compositions and methods for improving immune system function. In particular, provided herein are compositions, methods, and uses of YY1 and EZH2 inhibitors for preventing and reversing T-cell exhaustion (e.g., for use in immunotherapy).

公开(公告)号：US20220409713A1

公开(公告)日：2022-12-29

申请号：US17831012

申请日：2022-06-02

Applicant: Tufts Medical Center, Inc.

Inventor： Edouard VANNIER ,  Joseph J. CAMPO, JR.

IPC: A61K39/018 ,  C07K16/20 ,  G01N33/569

Abstract: Described herein are compositions that comprise one or more Babesia microti antigens, one or more Babesia microti nucleic acid molecules, or one or more anti-Babesia microti antibodies and uses thereof in methods for the prophylaxis of babesiosis, the treatment of babesiosis and the monitoring of individuals undergoing prophylactic or therapeutic administration of the compositions of the invention.

公开(公告)号：US20220395564A1

公开(公告)日：2022-12-15

申请号：US17779633

申请日：2020-11-25

Applicant: Tufts Medical Center, Inc.

Inventor： Edouard VANNIER ,  Joseph J. CAMPO, JR.

IPC: A61K39/018 ,  C07K16/20 ,  G01N33/569

Abstract: Described herein are compositions that comprise one or more Babesia microti antigens, one or more Babesia microti nucleic acid molecules, or one or more anti-Babesia microti antibodies and uses thereof in methods for the prophylaxis of babesiosis, the treatment of babesiosis and the monitoring of individuals undergoing prophylactic or therapeutic administration of the compositions of the invention.