公开(公告)号：US12130235B2

公开(公告)日：2024-10-29

申请号：US17205473

申请日：2021-03-18

申请人： Johnson & Johnson Consumer Inc.

发明人： Curt Binner ,  Justin Mellinger ,  Alexandru Paunescu

IPC分类号： G01N21/31 ,  A61F13/42 ,  A61F13/49 ,  B01L3/00 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/78 ,  G01N33/493 ,  G01N33/52 ,  G01N21/77

CPC分类号： G01N21/78 ,  A61F13/42 ,  A61F13/49 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502776 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/31 ,  G01N33/493 ,  G01N33/52 ,  B01L2200/10 ,  G01N2021/7756 ,  G01N2021/7766 ,  G01N2201/062

摘要： A system and kit for measuring analyte concentration in a bodily fluid include a durable component, at least one indicator component including an indicator zone, and at least one moisture sensor. The kit has multiple individually packaged indicator components. Methods of measuring analyte concentration in bodily fluids include the steps of collecting and transporting bodily fluid to at least one colorimetric analyte sensing element and detecting the presence of bodily fluid in contact with the at least one colorimetric analyte sensing element, collecting optical data relating to the at least one colorimetric analyte sensing element with at least one spectrophotometer after a predetermined time period after detecting the presence of bodily fluid, communicating the optical data to a computing system having at least one processor and data storage, and analyzing the optical data to determine at least one analyte concentration in the bodily fluid.

公开(公告)号：US20230366881A1

公开(公告)日：2023-11-16

申请号：US18127887

申请日：2023-03-29

申请人： Hai Kang Life Corporation Limited

发明人： Cheung Hoi Yu ,  Shui Ying Tsang ,  Wing Cheong Chan

IPC分类号： G01N33/569 ,  G01N21/78 ,  G01N33/543 ,  G06T7/90

CPC分类号： G01N33/56983 ,  G01N21/78 ,  G01N33/54388 ,  G06T7/90 ,  G01N2021/7766

摘要： The application relates to a method and device for quantitatively analyzing the detection results of lateral flow-type test kits. Disclosed is a method for quantitatively analyzing the test results of a lateral flow-type test kit wherein the test kit includes a result area in which a control C-line region and a detection T-line region are set. The method includes: determining an analyte concentration range that the test kit can detect; diluting a sample into a plurality of sample dilutions having different pre-determined analyte concentrations within the determined analyte concentration range; applying each sample dilution having a pre-determined analyte concentration to a sampling well on the rapid test kit for the analyte, so as to obtain separate resulting images with different color intensities on the T-line region corresponding to different pre-determined analyte concentrations; calculating a corresponding color intensity index values for the T-line regions of each resulting image, respectively; and creating a continuous curve by fitting the corresponding plurality of color intensity index values to the plurality of different pre-determined analyte concentrations, wherein the corresponding analyte concentration can be obtained based on the color intensity index value at any point on the continuous curve.

公开(公告)号：US20170209313A1

公开(公告)日：2017-07-27

申请号：US15449721

申请日：2017-03-03

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： A61F13/42 ,  G01N33/52 ,  G01N33/53 ,  A61F13/15

CPC分类号： G01N33/94 ,  A61F13/00055 ,  A61F13/15 ,  A61F13/42 ,  A61F13/84 ,  A61F2013/422 ,  A61F2013/429 ,  A61F2013/8473 ,  G01N21/78 ,  G01N33/146 ,  G01N33/52 ,  G01N33/525 ,  G01N33/53 ,  G01N33/54366 ,  G01N33/558 ,  G01N2021/775 ,  G01N2021/7763 ,  G01N2021/7766

摘要： Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

公开(公告)号：US20170067881A1

公开(公告)日：2017-03-09

申请号：US15257238

申请日：2016-09-06

申请人： Bruce McCord ,  George Duncan ,  Ashley Wardlow

发明人： Bruce McCord ,  George Duncan ,  Ashley Wardlow

IPC分类号： G01N33/52 ,  G01N21/78 ,  B01L3/00

CPC分类号： G01N33/521 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2400/0406 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/346 ,  G01N33/52 ,  G01N2021/752 ,  G01N2021/7766 ,  G01N2035/00108

摘要： Paper microfluidic devices for the detection of bodily fluids are provided. Such devices can be used, for example, for detection of bodily fluids from or at crime scenes, including blood, saliva, semen, urine, feces, vaginal fluids, and perspiration. Detection can be performed using colorimetric reagents that react when placed in contact with the fluid of interest. A single device can be used to test for multiple bodily fluids at the same time.

摘要翻译： 提供了用于检测体液的纸微流体装置。 这样的装置可用于例如从犯罪现场检测体液，包括血液，唾液，精液，尿液，粪便，阴道液和汗液。 可以使用当与感兴趣的流体接触放置时反应的比色试剂进行检测。 单个装置可用于同时测试多种体液。

公开(公告)号：US08420025B2

公开(公告)日：2013-04-16

申请号：US13359023

申请日：2012-01-26

申请人： Radislav A. Potyrailo ,  Prashant V. Shrikhande ,  Scott M. Boyette ,  Caibin Xiao ,  Andrew M. Leach

发明人： Radislav A. Potyrailo ,  Prashant V. Shrikhande ,  Scott M. Boyette ,  Caibin Xiao ,  Andrew M. Leach

IPC分类号： B01L3/00 ,  G01N15/06 ,  G01N21/00 ,  C12M1/00 ,  C12M1/34

CPC分类号： G01N21/78 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0427 ,  B01L2400/0448 ,  G01N21/80 ,  G01N35/00069 ,  G01N2021/7766 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2021/7793 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2575

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20100284020A1

公开(公告)日：2010-11-11

申请号：US12463009

申请日：2009-05-08

申请人： Glen A. Sanders

发明人： Glen A. Sanders

IPC分类号： G01B9/02 ,  G02B6/032 ,  G02B6/00

CPC分类号： G02B6/02385 ,  G01N21/39 ,  G01N21/7746 ,  G01N2021/7766 ,  G01N2021/7789 ,  G02B6/02366

摘要： Apparatus and method for chemical and biological agent sensing. An example sensing apparatus includes a resonator having a resonance frequency. The resonator includes a coil of a photonic crystal fiber. The photonic crystal fiber has a solid region configured to guide a substantially single optical mode of light having, a cladding surrounding an exterior of the solid region, and at least one hollow core within the cladding. The cladding contains at least one hollow core. The photonic crystal fiber is configured to introduce a fluid that may contain an analyte to the hollow core. The photonic crystal fiber is configured so that the light interacts with the fluid. The resonator is configured to produce a resonance signal centered at the resonance frequency. A predetermined change in the resonance signal indicates a presence of a quantity of the analyte in the fluid.

摘要翻译： 用于化学和生物试剂感测的装置和方法。 感测装置的示例包括具有共振频率的谐振器。 谐振器包括光子晶体光纤的线圈。 光子晶体光纤具有被配置为引导基本上单一的光学模式的固体区域，该光学模式具有围绕固体区域的外部的包层以及包层内的至少一个空心芯。 包层至少包含一个中空芯。 光子晶体光纤被配置为将可能含有分析物的流体引入中空芯。 光子晶体光纤被配置成使得光与流体相互作用。 谐振器被配置为产生以谐振频率为中心的谐振信号。 谐振信号中的预定变化表示流体中存在一定量的分析物。

公开(公告)号：US20180297030A1

公开(公告)日：2018-10-18

申请号：US16014034

申请日：2018-06-21

申请人： Roche Diabetes Care, inc.

发明人： Bernd Hiller ,  Rudolf Pachl ,  Daniela Pfiffi ,  Ewald Rieger ,  Christa Sternberger

IPC分类号： B01L3/00 ,  C12Q1/54 ,  G01N21/77 ,  G01N33/543

CPC分类号： B01L3/502707 ,  B01L2200/12 ,  B01L2300/041 ,  B01L2300/161 ,  B01L2400/0406 ,  C12Q1/54 ,  G01N21/77 ,  G01N33/54386 ,  G01N2021/7766 ,  G01N2021/7796

摘要： Methods are disclosed for manufacture of test elements for detecting at least one analyte in a body fluid, where the test elements include a housing having at least one base element and at least one cover element. The methods include providing the base element, and mounting the cover element to the base element with an adhesive, wherein the adhesive contacts at least one test field of the cover element such that the adhesive is interposed between the test field and the base element and at least partially covers the test field. The test elements also include at least one fluid channel formed within the housing, where the the fluid channel includes a capillary region and a measurement region. The capillary region and the measurement region have differing aspect ratios. The at least one test field has at least one test chemical, where the test chemical is adapted to change at least one optically measurable property in the presence of the analyte.

公开(公告)号：US20180141039A1

公开(公告)日：2018-05-24

申请号：US15820136

申请日：2017-11-21

申请人： Access Sensor Technologies

发明人： Thomas H. Reilly, III ,  John B. Wydallis

IPC分类号： B01L3/00 ,  G01N33/52 ,  G01N21/78

CPC分类号： B01L3/502 ,  B01L3/5023 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0887 ,  G01N21/78 ,  G01N33/525 ,  G01N2021/752 ,  G01N2021/7763 ,  G01N2021/7766

摘要： An analyte detection device includes a fluid impermeable layer having a first thickness and at least one inlet port having a diameter, the at least one inlet port defining a fluid pathway through the first thickness. The device also includes a reagent-hosting layer having a second thickness and including at least one of a chemical reagent and a bio-chemical reagent. The reagent-hosting layer is configured to radially receive a sampling fluid via the fluid pathway, where the sampling fluid is configured to interact with the at least one of a chemical reagent and a bio-chemical reagent in the reagent-hosting layer to indicate a characteristic associated with an analyte in the sampling fluid.

公开(公告)号：US09791434B2

公开(公告)日：2017-10-17

申请号：US15257238

申请日：2016-09-06

申请人： Bruce McCord ,  George Duncan ,  Ashley Wardlow

发明人： Bruce McCord ,  George Duncan ,  Ashley Wardlow

IPC分类号： B01L3/00 ,  G01N33/50 ,  G01N33/48 ,  G01N33/34 ,  G01N33/52 ,  G01N21/78 ,  G01N1/28 ,  G01N21/75 ,  G01N1/00 ,  G01N21/77 ,  G01N35/00 ,  G01N21/84

CPC分类号： G01N33/521 ,  B01L3/5027 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2400/0406 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/346 ,  G01N33/52 ,  G01N2021/752 ,  G01N2021/7766 ,  G01N2035/00108

摘要： Paper microfluidic devices for the detection of bodily fluids are provided. Such devices can be used, for example, for detection of bodily fluids from or at crime scenes, including blood, saliva, semen, urine, feces, vaginal fluids, and perspiration. Detection can be performed using colorimetric reagents that react when placed in contact with the fluid of interest. A single device can be used to test for multiple bodily fluids at the same time.

公开(公告)号：US20170269108A1

公开(公告)日：2017-09-21

申请号：US15606119

申请日：2017-05-26

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： G01N33/94 ,  G01N33/558 ,  G01N33/14 ,  G01N33/543

CPC分类号： G01N33/94 ,  A61F13/00055 ,  A61F13/15 ,  A61F13/42 ,  A61F13/84 ,  A61F2013/422 ,  A61F2013/429 ,  A61F2013/8473 ,  G01N21/78 ,  G01N33/146 ,  G01N33/52 ,  G01N33/525 ,  G01N33/53 ,  G01N33/54366 ,  G01N33/558 ,  G01N2021/775 ,  G01N2021/7763 ,  G01N2021/7766

摘要： Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.