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102 条记录 (耗时 0.028 秒)

    Multi-reflecting time of flight mass analyser
    1.
    发明授权
    Multi-reflecting time of flight mass analyser 有权

    公开(公告)号：US11342175B2

    公开(公告)日：2022-05-24

    申请号：US17054351

    申请日：2019-05-03

    申请人： Micromass UK Limited

    发明人： Jeffery Mark Brown ,  Boris Kozlov

    IPC分类号： H01J49/40 ,  H01J49/02 ,  H01J49/06

    摘要： A mass spectrometer comprising: a multi-reflecting time of flight (MRTOF) mass analyser or mass separator having two gridless ion mirrors 2 that are elongated in a first dimension (Z-dimension) and configured to reflect ions multiple times in a second orthogonal dimension (X-dimension) as the ions travel in the first dimension; the spectrometer configured to operate in: (i) a first mode for ions having a first rate of interaction with background gas molecules in the mass analyser or separator, such that the ions are reflected a first number of times between the ion mirrors 2; and (ii) a second mode for ions having a second, higher rate of interaction with background gas molecules in the mass analyser or separator, such that ions are reflected a second, lower number of times between the ion mirrors 2.

    Method of transmitting ions through an aperture
    2.
    发明授权
    Method of transmitting ions through an aperture 有权

    公开(公告)号：US10388503B2

    公开(公告)日：2019-08-20

    申请号：US15953913

    申请日：2018-04-16

    申请人： MICROMASS UK LIMITED

    发明人： Jeffery Mark Brown ,  Paul Murray

    IPC分类号： H01J49/40 ,  H01J49/06 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16

    摘要： Methods and apparatuses for transmitting ions through an aperture are described. In one embodiment, a mass spectrometer may include an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected while they separate according to mass to charge ratio in the flight region and such that the ions are focused to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, while naturally converging the ion beam to a focus. As this focus is arranged at the aperture, it enables the aperture to be made relatively small while still maintaining high ion transmission efficiency.

    Method of introducing ions into a vacuum region of a mass spectrometer
    3.
    发明授权
    Method of introducing ions into a vacuum region of a mass spectrometer 有权

    公开(公告)号：US10319575B2

    公开(公告)日：2019-06-11

    申请号：US15501599

    申请日：2015-08-05

    申请人： Micromass UK Limited

    发明人： Jeffery Mark Brown ,  Martin Raymond Green

    IPC分类号： H01J49/04 ,  G01N27/62 ,  H01J49/00

    摘要： A method of mass or ion mobility spectrometry is disclosed. The method comprises providing a spectrometer comprising an orifice between an atmospheric and a sub-atmospheric pressure region of the spectrometer, wherein the latter comprises an ion guide or ion trap; providing a sample probe comprising a needle assembly on which a sample is deposited or that is supplied with a sample; inserting the needle assembly through the orifice into the sub-atmospheric pressure region so that the sample is arranged within or adjacent to the ion guide or trap in the sub-atmospheric pressure region; and then desorbing the sample from the needle assembly within the sub-atmospheric pressure region and/or ionizing the sample within the sub-atmospheric pressure region so as to generate ions that enter the ion guide or ion trap. The proximity of the sample to the ion guide or trap allows analyte ions from the sample to be captured efficiently.

    Liquid extraction matrix assisted laser desorption ionisation ion source
    4.
    发明授权
    Liquid extraction matrix assisted laser desorption ionisation ion source 有权

    公开(公告)号：US10090144B2

    公开(公告)日：2018-10-02

    申请号：US15126721

    申请日：2015-03-18

    申请人： Micromass UK Limited

    发明人： Jeffery Mark Brown

    IPC分类号： H01J49/00 ,  H01J49/16 ,  H01J49/04

    摘要： A Matrix Assisted Laser Desorption Ionization (“MALDI”) ion source is disclosed comprising a first device arranged and adapted to supply a flow of liquid on to the surface of a target or a sample to be analyzed so that the liquid forms a liquid junction on the surface of the target or the sample to be analyzed and wherein analyte molecules to be ionized are extracted into the liquid junction, and a laser source emits a laser beam which causes analyte ions or an analyte plume to be released or desorbed from the liquid junction.

    Charge-stripping of multiply-charged ions
    6.
    发明授权
    Charge-stripping of multiply-charged ions 有权

    公开(公告)号：US09905406B2

    公开(公告)日：2018-02-27

    申请号：US15031015

    申请日：2014-10-23

    申请人： Micromass UK Limited ,  The University of British Columbia

    发明人： Jeffery Mark Brown ,  Damon Robb

    IPC分类号： H01J49/00 ,  H01J49/16

    CPC分类号： H01J49/0077 ,  H01J49/00 ,  H01J49/165

    摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed wherein a sample is ionized by an electrified sprayer so as to produce multiply charged analyte ions of a first polarity in gas-phase. A reaction region is provided downstream of the electrified sprayer, wherein the reaction region is maintained substantially at atmospheric pressure and is maintained substantially free of electric-fields. A gas flow is provided from said electrified sprayer to said reaction region such that the gas flow carries the analyte ions from the electrified sprayer into the reaction region. Free electrons or reagent ions of a second polarity are generated in the reaction region, wherein the second polarity is opposite to said first polarity. The free electrons or reagent ions are then reacted with the analyte ions in the reaction region so as to reduce the charge state of the multiply charged analyte ions and thereby produce charge-reduced analyte ions.