公开(公告)号：US10978288B2

公开(公告)日：2021-04-13

申请号：US16541425

申请日：2019-08-15

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/24 ,  H01J49/06

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure

公开(公告)号：US20200350149A1

公开(公告)日：2020-11-05

申请号：US16929840

申请日：2020-07-15

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/24 ,  H01J49/10 ,  H01J49/40 ,  H01J49/14

Abstract: A miniature mass spectrometer includes an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber downstream of the first vacuum chamber, and a third vacuum chamber downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The mass spectrometer also includes a tandem quadrupole mass analyser, 3D ion trap mass analyser, 2D or linear ion trap mass analyser, Time of Flight mass analyser, quadrupole-Time of Flight mass analyser, or electrostatic mass analyser arranged in the third vacuum chamber.

公开(公告)号：US20200013607A1

公开(公告)日：2020-01-09

申请号：US16541425

申请日：2019-08-15

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/24 ,  H01J49/00 ,  H01J49/06

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source 701, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump 707 is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure

公开(公告)号：US09929002B2

公开(公告)日：2018-03-27

申请号：US15105092

申请日：2014-12-17

Applicant: Micromass UK Limited

Inventor： Kevin Giles ,  Martin Raymond Green ,  Darren Hewitt ,  Daniel James Kenny ,  David J. Langridge ,  Steven Derek Pringle ,  Jason Lee Wildgoose

IPC: H01J49/42

CPC classification number: H01J49/4215

Abstract: A mass spectrometer is disclosed comprising a first mass filter comprising a plurality of electrodes and a first device arranged and adapted to generate an axial force which drives at least some ions axially through or along the first mass filter and a quadrupole mass filter or mass analyzer arranged downstream of the mass filter.

公开(公告)号：US09852895B2

公开(公告)日：2017-12-26

申请号：US14445224

申请日：2014-07-29

Applicant: Micromass UK Limited

Inventor： Daniel James Kenny

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/06

CPC classification number: H01J49/0045 ,  H01J49/0031 ,  H01J49/06 ,  H01J49/10

Abstract: A mass spectrometer is disclosed comprising an on trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis.

公开(公告)号：US09842727B2

公开(公告)日：2017-12-12

申请号：US15022444

申请日：2014-09-17

Applicant: Micromass UK Limited

Inventor： David Gordon ,  Daniel James Kenny ,  Howard Read ,  Kate Whyatt

IPC: H01J49/00 ,  H01J49/10

CPC classification number: H01J49/0009 ,  H01J49/0031 ,  H01J49/10

Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.

公开(公告)号：US09625471B2

公开(公告)日：2017-04-18

申请号：US14563108

申请日：2014-12-08

Applicant: Micromass UK Limited

Inventor： Christopher John Hughes ,  Therese McKenna ,  David Gordon ,  Daniel James Kenny

IPC: G01N24/00 ,  G01N33/68 ,  H01J49/00

CPC classification number: G01N33/6848 ,  H01J49/0031 ,  H01J49/0045 ,  Y10T436/24

Abstract: A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed.

公开(公告)号：US09536724B2

公开(公告)日：2017-01-03

申请号：US14386974

申请日：2013-03-15

Applicant: Micromass UK Limited

Inventor： John Richard Garside ,  Martin Raymond Green ,  Daniel James Kenny ,  Jeffrey Ellis Lockett ,  Richard Barrington Moulds

IPC: H01J49/06

CPC classification number: H01J49/065 ,  H01J49/066 ,  H01J49/068 ,  Y10T29/49126

Abstract: A method of constructing an ion guide is disclosed comprising providing an elongated spine member and a plurality of plates. Each plate comprises an aperture therethrough for receiving the spine member and at least one electrode for use in guiding ions. The apertures of the plates are arranged around the spine member and the plates are arranged along the spine member. The plates are then locked in position on the spine member such that the plates are fixed axially with respect to the spine member and so that the electrodes of the plates are arranged so as to form an array of electrodes for use in guiding ions.

Abstract translation: 公开了构造离子导向器的方法，其包括提供细长的脊柱构件和多个板。 每个板包括穿过其中的孔，用于接收脊柱构件和用于引导离子的至少一个电极。 板的孔布置在脊柱构件周围，并且板沿着脊柱构件布置。 然后将板锁定在脊柱构件上的适当位置，使得板相对于脊柱构件轴向固定，并且使得板的电极被布置成形成用于引导离子的电极阵列。

公开(公告)号：US20160093480A1

公开(公告)日：2016-03-31

申请号：US14892374

申请日：2014-05-29

Applicant: MICROMASS UK LIMITED

Inventor： David Gordon ,  Daniel James Kenny

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/06

CPC classification number: H01J49/0013 ,  H01J49/0031 ,  H01J49/062 ,  H01J49/16 ,  H01J49/24

Abstract: A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure

Abstract translation: 公开了一种微型质谱仪，其包括大气压电离源，具有大气压采样孔或毛细管的第一真空室，位于第一真空室下游的第二真空室和位于第二真空室下游的第三真空室。 第一真空泵布置并适于泵送第一真空室，其中第一真空泵被布置并适于将第一真空室保持在10mbar的压力。 第一RF离子导向器位于第一真空室内。 离子检测器位于第三真空室中。 从大气压采样孔或毛细管到离子检测器的离子检测表面的离子路径长度为400毫米。 质谱仪还包括分流式涡轮分子真空泵，其包括连接到第二真空室的中间或级间端口和连接到第三真空室的高真空（“HV”）端口。 第一真空泵也被布置并适于作为分流式涡轮分子真空泵的背衬真空泵。 第一台真空泵具有最大的泵送速度，nlE; 10 m3 / hr（2.78 L / s）。

公开(公告)号：US20160071716A1

公开(公告)日：2016-03-10

申请号：US14941741

申请日：2015-11-16

Applicant: Micromass UK Limited

Inventor： Jeffery Mark Brown ,  Paul Murray ,  Daniel James Kenny

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/06

CPC classification number: H01J49/062 ,  H01J49/0004 ,  H01J49/0463 ,  H01J49/065 ,  H01J49/164 ,  H01J49/26

Abstract: An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.

Abstract translation: 公开了一种用于质谱仪的离子源，其包括将激光束聚焦到目标衬底的上表面上的透镜和反射镜装置。 镜头具有有效的焦距＆nlE; 300 mm。 激光束以一定角度被引导到靶基底上; 相对于与靶基板的垂直度，其中＆amp; nlE; 3°。 一个或多个离子导向器接收从目标衬底释放的离子，并沿基本上绕过透镜和反射镜的离子路径向上透射离子。