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    Mass Spectrometry Methods And Systems For High Pressure Charge State Control And/Or Fragmentation
    1.
    发明公开
    Mass Spectrometry Methods And Systems For High Pressure Charge State Control And/Or Fragmentation 审中-公开

    公开(公告)号：US20240162022A1

    公开(公告)日：2024-05-16

    申请号：US18283109

    申请日：2022-03-24

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Yves LE BLANC

    IPC: H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/24

    CPC classification number: H01J49/0045 ,  H01J49/022 ,  H01J49/063 ,  H01J49/24

    Abstract: Systems and methods described herein provide for charge state control of multiply-charged anions in a front end, high pressure ion guide. In some example aspects, a mass spectrometer system is provided comprising a first vacuum chamber (121) maintained at a pressure above about 500 mTorr. At least one ion guide (106) is disposed within the first vacuum chamber, the at least one ion guide comprising a plurality of rods extending along a central longitudinal axis. A controller (193) is configured to adjust an amplitude of an RF voltage signal provided to the plurality of rods so as to alternatively operate the ion guide in a first mode of operation with a lower amplitude of the RF voltage signal so as to reduce the likelihood of charge reduction by electron detachment so as to substantially maintain the isotopic distribution of the ions during transmission of ions through the ion guide, and a second mode of operation with a higher amplitude of the RF voltage signal so as to increase the likelihood of electron detachment from ions being transmitted therethrough.

    MASS SPECTROMETER AND METHOD
    2.
    发明公开
    MASS SPECTROMETER AND METHOD 审中-公开

    公开(公告)号：US20240136167A1

    公开(公告)日：2024-04-25

    申请号：US18554024

    申请日：2022-04-07

    Applicant: HGSG LTD

    Inventor： John Brian HOYES

    IPC: H01J49/02 ,  H01J49/00 ,  H01J49/42

    CPC classification number: H01J49/027 ,  H01J49/0045 ,  H01J49/4245 ,  H01J49/067

    Abstract: A charge detection mass spectrometer, CDMS, is described. The CDMS comprises: an electrostatic sector field ion trap and an inductive charge detector, wherein the electrostatic sector field ion trap is configured to define, at least in part, an ion path via the inductive charge detector; and a fragmentation device. A method is also described.

    MASS SPECTROMETRY DATA-INDEPENDENT ANALYSIS METHODS WITH IMPROVED EFFICIENCY
    5.
    发明公开
    MASS SPECTROMETRY DATA-INDEPENDENT ANALYSIS METHODS WITH IMPROVED EFFICIENCY 审中-公开

    公开(公告)号：US20230187192A1

    公开(公告)日：2023-06-15

    申请号：US17550845

    申请日：2021-12-14

    Applicant: THERMO FINNIGAN LLC

    Inventor： Philip M. REMES

    IPC: H01J49/00 ,  H01J49/42 ,  G01N30/86

    CPC classification number: H01J49/0036 ,  G01N30/8631 ,  H01J49/0045 ,  H01J49/421

    Abstract: A method of data-independent mass spectrometric analysis of compounds of a compound class of interest comprises: determining or retrieving a distribution, over a mass-to-charge (m/z) ratio range of interest, of a number of primary ion species of members of said compound class having m/z ratios within each respective one of a plurality of m/z sub-ranges of the m/z ratio range of interest; defining m/z positions of a set consisting of a number, nsb, of finite-width bins, within the m/z ratio range of interest, the set of bins excluding m/z sub-ranges within the m/z ratio range of interest that encompass fewer than a threshold number, tsb, of the primary ion species, wherein the defining based on the determined or received distribution; and performing a plurality of tandem mass analyses, each tandem mass analysis pertaining to primary ion species within a respective one of the defined bins.

    Deconvolution of Mixed Spectra
    8.
    发明申请
    Deconvolution of Mixed Spectra 审中-公开

    公开(公告)号：US20180240658A1

    公开(公告)日：2018-08-23

    申请号：US15750550

    申请日：2016-08-09

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： David Michael Cox ,  Gordana Ivosev

    IPC: H01J49/00 ,  H01J49/04 ,  H01J49/26

    CPC classification number: H01J49/0031 ,  H01J49/0027 ,  H01J49/004 ,  H01J49/0045 ,  H01J49/04 ,  H01J49/26

    Abstract: An m/z range of an ion beam is divided into two or more precursor ion mass selection windows. A pattern of two or more different window m/z ranges to be used during two or more successive cycles for at least one precursor ion mass selection window is determined. The pattern includes an initial window m/z range and one or more successively different window m/z ranges. Each of the one or more successively different window m/z ranges includes at least a portion of the initial window m/z range. A tandem mass spectrometer is instructed to select and fragment the two or more precursor ion mass selection windows during each cycle of a plurality of cycles and to repeatedly use the pattern for each group of two or more successive cycles of the plurality of cycles for the selection and fragmentation of the at least one precursor ion mass selection window.

    MASS SPECTROMETER USING GASTIGHT RADIO FREQUENCY ION GUIDE
    9.
    发明申请
    MASS SPECTROMETER USING GASTIGHT RADIO FREQUENCY ION GUIDE 审中-公开

    公开(公告)号：US20180233346A1

    公开(公告)日：2018-08-16

    申请号：US15434233

    申请日：2017-02-16

    Applicant: Bruker Daltonics, Inc.

    Inventor： Felician MUNTEAN ,  Stephen ZANON

    IPC: H01J49/42 ,  H01J49/24 ,  H01J49/06 ,  H01J49/00

    CPC classification number: H01J49/4215 ,  H01J49/0045 ,  H01J49/062 ,  H01J49/24

    Abstract: The disclosure relates to a mass spectrometer, comprising (a) a vacuum recipient containing ion handling elements of the mass spectrometer, the vacuum recipient having a plurality of walls which define a gastight volume and comprise at least one of an entrance and exit, wherein different portions of an ion path pass at least one of the entrance and exit and run through the gastight volume; and (b) a gastight radio frequency ion guide having an ion passage along an axis and being mounted gastight to at least one of the entrance and exit as to continue the ion path in its ion passage outside the gastight volume. Embodiments of the disclosure facilitate, in particular, reducing pumping volumes in the mass spectrometer and corresponding pumping requirements as well as lowering the size and weight of such an assembly.

    Time-of-flight mass spectrometer
    10.
    发明授权
    Time-of-flight mass spectrometer 有权

    公开(公告)号：US10020181B2

    公开(公告)日：2018-07-10

    申请号：US15504541

    申请日：2014-08-19

    Applicant: SHIMADZU CORPORATION

    Inventor： Daisuke Okumura

    IPC: H01J49/40 ,  H01J49/06

    CPC classification number: H01J49/401 ,  H01J49/0045 ,  H01J49/062 ,  H01J49/24 ,  H01J49/40

    Abstract: An ion transport optical system is disposed between a collision cell and an orthogonal acceleration unit. When releasing ions that are held in the collision cell, an accelerating electric field in which a large potential difference exists is created between an exit-side end of an ion guide and a first stage of the ion transport optical system, and a decelerating electric field in which a relatively small potential difference exists is created between a final stage of the ion transport optical system and an entrance end of the orthogonal acceleration unit. In the accelerating electric field, the velocity of ions is increased overall by imparting a large amount of energy to the ions, and spreading of ions in the ion travel direction that is caused by differences between the mass-to-charge ratios of the ions is reduced.

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