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公开(公告)号：US12131895B2
公开(公告)日：2024-10-29
申请号：US17717505
申请日：2022-04-11
申请人： Micromass UK Limited
发明人： John Brian Hoyes , Boris Kozlov
CPC分类号： H01J49/401 , H01J49/061 , H01J49/406 , H01J49/408 , H01J49/4245
摘要： A Time of Flight mass analyser is disclosed comprising: at least one ion mirror 34 for reflecting ions; an ion detector 36 arranged for detecting the reflected ions; a first pulsed ion accelerator 30 for accelerating an ion packet in a first dimension (Y-dimension) towards the ion detector 36 so that the ion packet spatially converges in the first dimension as it travels to the detector 36; and a pulsed orthogonal accelerator 32 for orthogonally accelerating the ion packet in a second, orthogonal dimension (X-dimension) into one of said at least one ion mirrors 34.
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公开(公告)号：US20240355610A1
公开(公告)日：2024-10-24
申请号：US18634324
申请日：2024-04-12
发明人： Sebastian BÖHM , Andreas HAASE
CPC分类号： H01J49/403 , H01J49/0004 , H01J49/0418 , H01J49/164 , H01J49/405
摘要： The disclosure relates to devices and methods for the spectrometric analysis of sample material located on a sample support, and in particular on a flat sample support plate, using axial time-of-flight analysis. One operating mode of the devices and methods comprises an adjustment of the pulse focal position for the abrupt ablation and/or abrupt desorption of sample material in a z-direction that is perpendicular to a tangential plane at the location of ablation and/or desorption at the sample support, and the selection of a suitable setting for an acceleration with time lag of the ablated and/or desorbed and ionized sample material onto a flight path. It can be particularly advantageous to use these devices and methods in mass spectrometry imaging (MSI). The devices and methods can, in particular, be used with laser desorption/ionization (LDI) and specifically matrix-assisted laser desorption/ionization (MALDI).
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公开(公告)号：US20240355609A1
公开(公告)日：2024-10-24
申请号：US18635947
申请日：2024-04-15
申请人： SHIMADZU CORPORATION
发明人： Hiroko UEDA , Yusuke TATEISHI
CPC分类号： H01J49/40 , H01J49/0036 , H01J49/0009
摘要： A plurality of partial mass-to-charge-ratio ranges are defined so that neighboring partial mass-to-charge-ratio ranges overlap each other at a mass-to-charge ratio of a reference ion (Step 2). Mass spectrometry data of a known compound is acquired in each partial mass-to-charge-ratio range (Steps 3 and 4). A normalization coefficient is determined based on a measured intensity of the reference ion in the mass spectrometry data acquired in each of the neighboring partial mass-to-charge-ratio ranges (Steps 6 and 9). Mass spectrometry data of a measurement-target sample is acquired in each partial mass-to-charge-ratio range (Step 12). The mass spectrometry data of the measurement-target sample acquired in each partial mass-to-charge-ratio range is normalized by being multiplied by the corresponding normalization coefficient (Step 14). The normalized mass spectrometry data of the plurality of partial mass-to-charge-ratio ranges is integrated into one set of mass spectrometry data (Step 15).
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公开(公告)号：US12087569B2
公开(公告)日：2024-09-10
申请号：US17768747
申请日：2020-08-17
申请人： SHIMADZU CORPORATION
发明人： Takuro Kishida , Yasushi Aoki , Toshitaka Kawai
CPC分类号： H01J49/40 , H01J49/022
摘要： A time-of-flight mass spectrometry device includes an electrode to which a DC high voltage is applied in order to form an ion flight space and a high voltage power supply device that applies the high voltage to the electrode. The high voltage power supply device includes a high voltage generating circuit that generates the high voltage, and a voltage control circuit that is selectively set to a convergence responsiveness priority mode in which the high voltage generating circuit is controlled such that the high voltage has first convergence responsiveness and first stability or a stability priority mode in which the high voltage generating circuit is controlled such that the high voltage has second convergence responsiveness that is lower than the first convergence responsiveness and second stability that is higher than the first stability.
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公开(公告)号：US20240282559A1
公开(公告)日：2024-08-22
申请号：US18650681
申请日：2024-04-30
申请人： Micromass UK Limited
CPC分类号： H01J49/0022 , H01J49/062 , H01J49/24 , H01J49/40
摘要： A start-up routine for a mass spectrometer is performed automatically upon switching ON the mass spectrometer. The mass spectrometer comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use. The start-up routine comprises detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection. The mass spectrometer automatically determines whether configuration information is stored locally in respect of each one of the detected functional modules, and, for the or each one of the detected functional modules for which such information is found to be stored locally, automatically uses the information in configuring the mass spectrometer, and, for any detected functional module(s) for which such information is not found to be stored locally, automatically obtains configuration information for the detected functional module(s) from a remote server, and uses the information in configuring the mass spectrometer.
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公开(公告)号：US12009193B2
公开(公告)日：2024-06-11
申请号：US17059809
申请日：2019-05-31
申请人： Micromass UK Limited
CPC分类号： H01J49/0022 , H01J49/062 , H01J49/24 , H01J49/40
摘要： A start-up routine for a mass spectrometer is performed automatically upon switching ON the mass spectrometer. The mass spectrometer comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use. The start-up routine comprises detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection. The mass spectrometer automatically determines whether configuration information is stored locally in respect of each one of the detected functional modules, and, for the or each one of the detected functional modules for which such information is found to be stored locally, automatically uses the information in configuring the mass spectrometer, and, for any detected functional module(s) for which such information is not found to be stored locally, automatically obtains configuration information for the detected functional module(s) from a remote server, and uses the information in configuring the mass spectrometer.
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7.发明授权公开(公告)号：US11996280B2
公开(公告)日：2024-05-28
申请号：US17623598
申请日：2020-06-27
申请人： Zeteo Tech, Inc.
CPC分类号： H01J49/164 , G01N15/10 , G01N27/64 , H01J49/0036 , H01J49/40 , G01N2015/1029 , G01N2015/103
摘要： Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles, without pre-treatment using complex organic MALDI matrices. A continuous timing laser may be used to index aerosol particles, measure particle properties, and trigger a pulse ionization laser. Ionized fragments and optionally photons associated with each particle producing by the ionization laser may be analyzed using one or more detectors including a TOF-MS detector and an optical detector. The laser pulse may comprise a simultaneous IR and UV laser pulse when fragments comprise predominantly of UV chromophores. Unique spectral data associated with each indexed particle from each detector may be compiled using data fusion to generate compiled spectral data. Machine learning methods may be used to improve the prediction of composition over time.
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公开(公告)号：US11996277B2
公开(公告)日：2024-05-28
申请号：US17660525
申请日：2022-04-25
CPC分类号： H01J49/0036 , H01J49/025 , H01J49/406
摘要： A method of gain calibration for an ion detector operating at a detector voltage is described. The method includes steps of: generating single ions; determining a parameter of a first relationship between a detector output of an ion detector and a number of ions for a first detector voltage; detecting an ion peak at the ion detector using the first detector voltage; adjusting the detector voltage; and determining a parameter of a second relationship between the detector output and the number of ions for the second detector voltage. A system including a mass spectrometer arrangement and a controller configured to operate the mass spectrometer arrangement in accordance with this method is also described.
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公开(公告)号：US11990328B2
公开(公告)日：2024-05-21
申请号：US17723652
申请日：2022-04-19
申请人： SHIMADZU CORPORATION
发明人： Hiroyuki Miura , Hideaki Izumi
CPC分类号： H01J49/408 , H01J49/24
摘要： A mass spectrometer 1 includes a vacuum container 5 divided into a first chamber 51 containing an ion trap 3 and a second chamber 52 containing a time-of-flight mass spectrometer 4. The ion trap 3 is held within an ion-trap-holding space 610 surrounded by a wall 61. In this wall 61, a cooling-gas discharge port 64 is formed in addition to an introduction-side ion passage port 62 and an ejection-side ion passage port 63. A cooling gas supplied into an ion-capturing space 315 of the ion trap 3 is discharged from the ion-trap-holding space 610 through the three ports. The provision of the cooling-gas discharge port 64 reduces the amount of cooling gas flowing into the ejection-side ion passage port 63 and interfering with the ejection of ions from the ion trap 3 into the time-of-flight mass spectrometer 4. Consequently, the detection intensity of the ions is improved.
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公开(公告)号：US11935735B2
公开(公告)日：2024-03-19
申请号：US17867594
申请日：2022-07-18
发明人： Michael J. Schoessow
CPC分类号： H01J49/4285 , H01J49/022 , H01J49/26 , H01J49/40 , H01J49/4225 , H01J49/4235 , H03H7/46
摘要： A circuit and method for providing high-voltage radio-frequency (RF) energy to an instrument at multiple frequencies includes a plurality of inputs each configured to receive an RF voltage signal oscillating at a corresponding frequency, and a step-up circuit for generating magnified RF voltage signals based on the received RF voltage signals. The step-up circuit includes an LC network operable to isolate the RF voltage signals at the plurality inputs from one another while preserving a voltage magnification from each input to a common output at each of the corresponding frequencies.
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