公开(公告)号：US11031225B2

公开(公告)日：2021-06-08

申请号：US16335077

申请日：2017-09-13

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. Covey ,  Yves LeBlanc ,  Bradley B. Schneider

IPC: H01J49/06 ,  G01N30/72 ,  G01N30/84

Abstract: Because most ion optics of mass spectrometry systems are subject to ion deposition and may exhibit significantly different behavior following substantial contamination (e.g., loss of sensitivity), fouled surfaces must be regularly cleaned to maintain sensitivity. While the surfaces of front-end components (e.g., curtain plates, orifice plates, Qjet, Q0, IQ0) may be relatively easy to clean, the fouling of components contained within the downstream high-vacuum chambers (e.g., Q1, IQ1) can incur substantial delays and expense as the high-vacuum chambers must be vented and substantially disassembled prior to cleaning. Methods and systems for controlling contamination of components of mass spectrometer systems are provided herein. By reducing the transmission of contaminating ions during non-data acquisition periods, the present teachings can increase throughput, improve robustness, and/or decrease the downtime typically required to vent/disassemble/clean the fouled components.

公开(公告)号：US20210020423A1

公开(公告)日：2021-01-21

申请号：US16971436

申请日：2019-02-20

Applicant: DH Technologies Development Pte. Ltd.

Inventor： John J. Corr ,  Thomas R. Covey ,  Peter Kovarik ,  Bradley B. Schneider

IPC: H01J49/16 ,  H01J49/00

Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.

公开(公告)号：US09921183B2

公开(公告)日：2018-03-20

申请号：US15104954

申请日：2014-12-06

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bradley B. Schneider ,  Hassan Javaheri ,  Thomas R. Covey

IPC: G01N27/06 ,  H01J49/04 ,  H01J49/42 ,  G01N27/62 ,  H01J49/00 ,  H01J49/24 ,  H01J49/06

CPC classification number: G01N27/624 ,  H01J49/0031 ,  H01J49/063 ,  H01J49/066 ,  H01J49/24

Abstract: Differential mobility spectrometry is performed under vacuum. Ions generated in a high pressure region are received from the inlet orifice of a vacuum chamber using a first ion guide located in the vacuum chamber. The first ion guide focuses the generated ions on a DMS device inlet end using a plurality of tapered electrodes. The DMS device is coaxial and adjacent to the first ion guide. The DMS device separates the focused ions using a plurality of electrodes. The inscribed diameter at the DMS device inlet end is larger than the inscribed diameter at the first ion guide exit end to maximize ion transfer. The separated ions are received from the DMS device using a second ion guide coaxial and adjacent to the DMS device. The second ion guide focuses the separated ions on an exit orifice of the vacuum chamber using a plurality of tapered electrodes.

公开(公告)号：US09846143B2

公开(公告)日：2017-12-19

申请号：US15438986

申请日：2017-02-22

Applicant: DH Technologies Development PTE Ltd. ,  Voislav Blagojevic ,  Diethard Bohme

Inventor： Voislav Blagojevic ,  Diethard Bohme ,  Thomas R. Covey ,  Bradley B. Schneider

IPC: H01J49/00 ,  G01N27/62

CPC classification number: G01N27/624

Abstract: A method and system for performing an ion mobility based analysis that ionizes the components of a sample into ions; provides a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such that a constant sized gap is formed there between, through which a drift gas flows; introducing said ions into the drift gas, wherein said drift gas also comprises a mixture of liquid modifiers.

公开(公告)号：US11664210B2

公开(公告)日：2023-05-30

申请号：US16971436

申请日：2019-02-20

Applicant: DH Technologies Development Pte. Ltd.

Inventor： John J. Corr ,  Thomas R. Covey ,  Peter Kovarik ,  Bradley B. Schneider

IPC: H01J49/16 ,  H01J49/10 ,  H01J49/00

CPC classification number: H01J49/107 ,  H01J49/0031 ,  H01J49/165

Abstract: In one aspect, an ion source for use in a mass spectrometry system is disclosed, which comprises a housing, a first and a second ion probe coupled to said housing, and a first and a second emitter configured for coupling, respectively, to said first and second ion probes. The first ion probe is configured for receiving a sample at a flow rate in nanoflow regime and the second ion probe is configured for receiving a sample at a flow rate above the nanoflow regime. Each of the ion probes includes a discharge end (herein also referred to as the discharge tip) for ionizing at least one constituent of the received sample. In some embodiment, each ion probe receives the sample from a liquid chromatography (LC) column. Further, the ion probes can be interchangeably disposed within the housing.

公开(公告)号：US11067538B2

公开(公告)日：2021-07-20

申请号：US16088103

申请日：2017-03-21

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Bradley B. Schneider ,  Erkinjon Nazarov ,  Thomas R. Covey

IPC: G01N27/624 ,  H01J49/00 ,  H01J49/16

Abstract: An apparatus includes a first electrode and a second electrode. The second electrode is placed in parallel with the first electrode to provide constant gap distance. The gap between the first electrode and the second electrode is at atmospheric pressure. Ions are introduced into the center of the gap and travel through the apparatus in a direction parallel to the first electrode and the second electrode. The apparatus is configured as a high-field symmetric-waveform apparatus for filtering high mobility ions or for fragmenting ions. The apparatus is also configured for three modes of operation: as a conventional DMS; as a filter high mobility ions; and as fragmentation device. A symmetric electric field is produced in the gap with a maximum density normalized field strength greater than 10 Td to filter high mobility ions and with a maximum density normalized field strength greater than 100 Td to fragment ions.

公开(公告)号：US09305762B2

公开(公告)日：2016-04-05

申请号：US13693837

申请日：2012-12-04

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. Covey ,  Bradley B. Schneider

IPC: G01N24/00 ,  H01J49/26 ,  G01N27/62 ,  H01J49/00

CPC classification number: H01J49/26 ,  G01N27/624 ,  H01J49/004 ,  Y10T436/24

Abstract: A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.

Abstract translation: 质量分析系统，包括低压解离区域和差动迁移谱仪。 差速迁移谱仪包括至少一对限定离子流路的过滤电极对，其中过滤电极基于样品离子的迁移率特性产生用于通过选定部分样品离子的电场。 差分迁移率光谱仪还包括电压源，其向至少一个滤光器电极提供DC和RF电压以产生电场;接收经过低压解离区域的样品离子的离子入口和离子出口 其输出所选择的样本离子部分。 质谱仪接收样品离子的部分或全部选定部分。

公开(公告)号：US20150076342A1

公开(公告)日：2015-03-19

申请号：US14395705

申请日：2013-05-17

Applicant: DH Technologies Development Pte. Ltd.

Inventor： John L. Campbell ,  Thomas Covey ,  Yves LeBlanc ,  Bradley B. Schneider

IPC: H01J49/16 ,  G01N27/62 ,  H01J49/00 ,  H01J49/04

CPC classification number: H01J49/165 ,  G01N27/622 ,  H01J49/0081 ,  H01J49/0431

Abstract: An electrospray ion source method and system is provided for detecting emitter failure comprising a liquid chromatography column suitable for chromatographic separation of a sample. The column can have an inlet for receiving the sample; and an outlet for ejecting the sample. A make-up flow channel is provided for introducing make-up flow of liquid to the sample post-column, wherein the make-up flow normalizes the spray current. An electrospray ionization source is provided having one or more electrospray ionization emitter nozzles for receiving the make-up flow containing sample. A power supply can provide a voltage to the one or more emitter nozzles, and a measurement device can measure and monitor the spray current.

Abstract translation: 提供了一种用于检测发射器故障的电喷雾离子源方法和系统，其包括适于样品色谱分离的液相色谱柱。 该柱可以具有用于接收样品的入口; 以及用于喷射样品的出口。 提供了补充流动通道，用于将液体的补充流引入样品后柱，其中补充流使标准化喷雾电流。 提供了具有一个或多个电喷雾电离发射器喷嘴的电喷雾离子源，用于接收含有补充流的样品。 电源可以向一个或多个发射器喷嘴提供电压，并且测量装置可以测量和监测喷射电流。

公开(公告)号：US20240186130A1

公开(公告)日：2024-06-06

申请号：US18554840

申请日：2022-04-14

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bradley B. Schneider ,  Leigh Bedford

IPC: H01J49/00 ,  H01J49/04

CPC classification number: H01J49/0031 ,  H01J49/004 ,  H01J49/0431

Abstract: Systems and methods are disclosed for automated method parameter configuration for differential mobility separations. As non-limiting examples, various aspects of this disclosure provide receiving a sample in an open port interface; transferring the sample to an ionization source; ionizing the transferred sample; introducing the ionized sample into a mass spectrometer; mass analyzing the ionized sample to produce an initial mass analysis result; determining a peak width of the initial mass analysis result; and determining a dwell time for subsequent measurements based on the determined peak width, a pre-defined number of data points across subsequent mass analysis peak widths, and a number of different analytes to be assessed for the sample. The sample may be diluted and transferred to the ionization source by a sample introduction apparatus selected from a group including an acoustic droplet ejector (ADE), a pneumatic ejector, a piezoelectric ejector, and a hydraulic ejector.

公开(公告)号：US10175197B2

公开(公告)日：2019-01-08

申请号：US15320561

申请日：2015-06-23

Applicant: DH Technologies Development PTE Ltd.

Inventor： Manuel Faur ,  Tiberiu Gera ,  Bradley B. Schneider ,  Farshid Tayyeb ,  John Vandermey

IPC: G01N27/62 ,  H01J49/02

Abstract: Apparatus, systems, and methods for reducing or eliminating crosstalk in ion mobility spectrometers are provided. In some aspects, the apparatus, systems, and methods can reduce or eliminate crosstalk without significantly increasing the overall capacitive load of the ion mobility system. In accordance with various aspects of the applicant's teachings, cross talk compensation circuits are disclosed herein that address resulting issues in RF pickup and/or crosstalk in ion mobility spectrometers used with high-sensitivity downstream mass spectrometers such as mass spectrometers having high velocity gas interfaces that can be coupled to the ion mobility spectrometer.