公开(公告)号：US11414785B2

公开(公告)日：2022-08-16

申请号：US16990568

申请日：2020-08-11

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Xiaoxiao Liu ,  Beatrice Muriithi ,  Edouard S. P. Bouvier

IPC: C40B40/10 ,  C12N15/10

Abstract: The present disclosure relates to protein arrays and methods of using the same for the detection, quantification and characterization of biomolecules that specifically bind to the array among various other biomolecules in a biological sample. Specifically, the present disclosure relates to protein arrays that include a plurality of immunoglobulin molecules derived from shark single-domain heavy chain antibody lacking light-chains but including at least one variable antigen-binding domain with a binding site for an antigen. The immunoglobulin molecules are immobilized on a substrate via a linker. Further encompassed herein are diagnostic devices and kits, comprising the protein array and methods of using same.

公开(公告)号：US11041834B2

公开(公告)日：2021-06-22

申请号：US16292610

申请日：2019-03-05

Applicant: Waters Technologies Corporation

Inventor： Abhijit Tarafder ,  Moon Chul Jung ,  Edouard S. P. Bouvier

IPC: G01N30/60 ,  B01L3/00 ,  G01N30/02 ,  G01N30/52 ,  G01N30/88

Abstract: A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective. A plurality of secondary channels each having a cross-sectional area and characteristic length such that analyte flow into and out of a secondary channel is substantially diffusive, each of the plurality of secondary channels having an entrance in fluidic communication with the primary channel wherein the entrance intersects the primary channel.

公开(公告)号：US11511213B2

公开(公告)日：2022-11-29

申请号：US15752121

申请日：2016-08-12

Applicant: Waters Technologies Corporation

Inventor： Jonathan L. Belanger ,  Hua Yang ,  Edouard S. P. Bouvier ,  Mathew DeLano ,  Raymond P. Fisk ,  Hillary B. Hewitson ,  Wade P. Leveille ,  Kevin Daniel Wyndham

IPC: B01D15/22 ,  G01N30/60 ,  B01D53/02 ,  C12M1/40 ,  C12M1/00 ,  B01L3/00 ,  G01N30/72 ,  G01N30/88

Abstract: Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

公开(公告)号：US11273390B2

公开(公告)日：2022-03-15

申请号：US16570534

申请日：2019-09-13

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Pamela C. Iraneta ,  Joseph A. Luongo ,  Joseph A. Jarrell

IPC: B01D15/22 ,  B01D15/16 ,  B01D15/20 ,  G01N30/30 ,  G01N30/54 ,  G01N30/88 ,  G01N30/02

Abstract: An apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column wherein the insulating member is formed from a vacuum chamber surrounding the chromatography column. Another apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column, wherein the insulating member includes aerogel. Also described is a method of insulating a chromatography column comprising forming a jacket surrounding the chromatography column, and creating a vacuum chamber in an area between the jacket and the chromatography column.

公开(公告)号：US11185795B2

公开(公告)日：2021-11-30

申请号：US15487599

申请日：2017-04-14

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Joseph A. Jarrell ,  Wade P. Leveille ,  Fabrice Gilles Ernest Gritti ,  Theodore A. Dourdeville ,  Michael O. Fogwill

IPC: B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  G01N30/30 ,  G01N30/60 ,  G01N30/02 ,  G01N30/32

Abstract: Apparatus and methods for performing chromatography may include a chromatography column and a vacuum insulated jacket having an inner wall and an outer wall. A vacuum area may be formed between the inner wall and the outer wall. The inner wall of the vacuum insulated jacket may surround the chromatography column. A gap may be formed between an outer wall of the chromatography column and the inner wall of the vacuum insulated jacket. The vacuum insulated jacket may extend beyond one or more end frits of the column. The gap may be filled with one or more materials so as to form an insulating or thermal barrier.

公开(公告)号：US10279283B2

公开(公告)日：2019-05-07

申请号：US15874469

申请日：2018-01-18

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Hua Yang ,  Edouard S. P. Bouvier

IPC: B01D15/22 ,  B32B5/02 ,  B01J20/28 ,  B01D15/10 ,  B01D15/08 ,  B01D15/18 ,  B01D15/34 ,  B01J20/283 ,  B01J20/26 ,  B01J20/285 ,  B01J20/32 ,  B01D15/38 ,  B01J35/10 ,  B32B1/02 ,  B32B3/26

Abstract: Embodiments of the present invention are directed to a porous monolith polymeric composition having utility in catalysis, chromatography, filtration, and electro-kinetic pumps, devices incorporating such composition and methods or making and using such monoliths. The monoliths are characterized by a substantially homogeneous skeletal core with little shrinkage, few voids and few channels.

公开(公告)号：US20250052727A1

公开(公告)日：2025-02-13

申请号：US18933343

申请日：2024-10-31

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Kevin Wyndham ,  Thomas H. Walter ,  Uwe D. Neue

IPC: G01N30/02 ,  B01D15/34 ,  B01J20/28 ,  B01J20/282 ,  B01J20/286 ,  G01N21/53

Abstract: The present invention is directed to a device and a method for performing size exclusion chromatography. Embodiments of the present invention feature devices and methods for size exclusion chromatography at normal high performance liquid chromatography or ultra performance liquid chromatography pressures and above using small particles.

公开(公告)号：US20210047637A1

公开(公告)日：2021-02-18

申请号：US16990568

申请日：2020-08-11

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Xiaoxiao Liu ,  Beatrice Muriithi ,  Edouard S. P. Bouvier

IPC: C12N15/10 ,  C40B40/10

Abstract: The present disclosure relates to protein arrays and methods of using the same for the detection, quantification and characterization of biomolecules that specifically bind to the array among various other biomolecules in a biological sample. Specifically, the present disclosure relates to protein arrays that include a plurality of immunoglobulin molecules derived from shark single-domain heavy chain antibody lacking light-chains but including at least one variable antigen-binding domain with a binding site for an antigen. The immunoglobulin molecules are immobilized on a substrate via a linker. Further encompassed herein are diagnostic devices and kits, comprising the protein array and methods of using same.

公开(公告)号：US10478750B2

公开(公告)日：2019-11-19

申请号：US14406285

申请日：2013-06-26

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Joseph Kareh

IPC: B01D15/16 ,  B01D15/20 ,  G01N30/54 ,  B01D15/22 ,  G01N30/02 ,  G01N30/30

Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.

公开(公告)号：US11351477B2

公开(公告)日：2022-06-07

申请号：US16595627

申请日：2019-10-08

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Edouard S. P. Bouvier ,  Joseph Kareh

IPC: B01D15/16 ,  B01D15/20 ,  G01N30/54 ,  B01D15/22 ,  G01N30/02 ,  G01N30/30

Abstract: Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column. A method of performing liquid chromatography comprises setting an inlet of a chromatography column to a first temperature using a first temperature control unit in thermal contact with said inlet, setting an outlet of the chromatography column to a second temperature using a second temperature control unit in thermal contact with the outlet, wherein the first temperature is less than the second temperature; and injecting a sample into a liquid stream that flows through the chromatography column after the inlet is set at the first temperature and the outlet is at the second temperature.