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    Wide range luminescent immunoassays
    2.
    发明授权
    Wide range luminescent immunoassays 有权

    公开(公告)号：US10451616B2

    公开(公告)日：2019-10-22

    申请号：US15429362

    申请日：2017-02-10

    Applicant: Access Medical Systems, LTD.

    Inventor： Robert F. Zuk

    IPC: G01N33/543 ,  G01N21/76 ,  G01N21/66 ,  G01N33/58 ,  G01N33/53

    Abstract: The present invention relates to a method for quantitating an analyte having a wide range concentration in a single assay without having to dilute the sample and repeating the assay. The key feature of the invention is having two cycles of events including sample binding to probe, binding reactions, and detection. After the first cycle of binding and detecting, the probe is dipped into the same sample vessel to bind additional analyte in the sample vessel at a condition that is more favorable to binding than the condition in the first cycle.

    METHOD FOR RE-USING TEST PROBE AND REAGENTS IN AN IMMUNOASSAY BASED ON INTERFEROMETRY
    3.
    发明申请
    METHOD FOR RE-USING TEST PROBE AND REAGENTS IN AN IMMUNOASSAY BASED ON INTERFEROMETRY 审中-公开

    公开(公告)号：US20190250154A1

    公开(公告)日：2019-08-15

    申请号：US16394953

    申请日：2019-04-25

    Applicant: Access Medical Systems, Ltd.

    Inventor： Robert F. Zuk ,  Qing Xia

    IPC: G01N33/543

    CPC classification number: G01N33/543

    Abstract: The present invention is directed an immunoassay method using an interference detection system. The assay re-uses an antibody-immobilized test probe and reagents for quantitating an analyte in different samples, from about 3 to 20 times, while maintaining acceptable clinical assay performance. The method regenerates the test probe with an acidic solution after completion of each cycle of reactions. The present invention is also directed to a unitized cartridge (a strip) for an immunoassay test. Each unitized cartridge contains all necessary reagents and can be used for 3-20 cycles to measure 3-20 different samples.

    Luminescent immunoassays for quantitating analytes having a wide concentration range
    6.
    发明授权
    Luminescent immunoassays for quantitating analytes having a wide concentration range 有权
    用于定量浓度范围宽的分析物的发光免疫测定

    公开(公告)号：US09568431B2

    公开(公告)日：2017-02-14

    申请号：US13794080

    申请日：2013-03-11

    Applicant: Access Medical Systems, LTD.

    Inventor： Robert F. Zuk

    IPC: G01N33/543 ,  G01N21/76 ,  G01N21/66 ,  G01N33/58

    CPC classification number: G01N33/54306 ,  G01N21/66 ,  G01N21/76 ,  G01N33/5308 ,  G01N33/582 ,  G01N2458/30 ,  G01N2458/40

    Abstract: The present invention relates to a method for quantitating an analyte having a wide range concentration in a single assay without having to dilute the sample and repeating the assay. The key feature of the invention is having two cycles of events including sample binding to probe, binding reactions, and detection. After the first cycle of binding and detecting, the probe is dipped into the same sample vessel to bind additional analyte in the sample vessel at a condition that is more favorable to binding than the condition in the first cycle.

    Abstract translation: 本发明涉及用于在单次测定中定量具有宽范围浓度的分析物的方法，而不必稀释样品并重复测定。 本发明的关键特征是具有两个循环的事件，包括样品结合到探针，结合反应和检测。 在结合和检测的第一个循环之后，将探针浸入相同的样品容器中，以比第一次循环中的条件更有利于结合的条件将样品容器中的另外的分析物结合。

    SYSTEMS FOR IMMUNOASSAY TESTS
    8.
    发明申请
    SYSTEMS FOR IMMUNOASSAY TESTS 有权
    免疫测试系统

    公开(公告)号：US20140295578A1

    公开(公告)日：2014-10-02

    申请号：US14301228

    申请日：2014-06-10

    Applicant: Access Medical Systems, LTD.

    Inventor： Hong TAN ,  Ming Xia ,  Yushan Tan ,  Jun Chen ,  Erhua Cao ,  Genqian Ll ,  Robert F. Zuk

    IPC: B01L3/00

    CPC classification number: B01L3/52 ,  B01L3/502 ,  B01L3/527 ,  B01L2300/042 ,  B01L2300/045 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/54366 ,  G01N35/026 ,  G01N2035/0436

    Abstract: This invention relates to a cartridge for an immunoassay test. The cartridge comprises (a) a probe well comprising a probe and a cap, the cap being in a closed position to enclose the probe in the probe well, wherein the probe has a bottom tip coated with analyte-binding molecules, (b) a sample well to receive a sample, (c) one or more reagent wells, (d) a plurality of wash wells each containing a first aqueous solution, and (e) a measurement well having a light transmissive bottom, the measurement well containing a second aqueous solution, wherein the openings of the sample well, reagent well, measurement well and wash wells are sealed. The present invention also relates to an apparatus for loading and releasing a probe. The apparatus comprises a push pin and a groove to load and transfer the probe to a plurality of locations, such as different wells in the above-mentioned cartridge, to conduct the immunoassay test.

    Abstract translation: 本发明涉及用于免疫测定试验的药筒。 所述盒包括（a）包括探针和帽的探针孔，所述盖处于关闭位置以将所述探针包围在所述探针中，其中所述探针具有涂覆有分析物结合分子的底部末端，（b） 样品井以接收样品，（c）一个或多个试剂孔，（d）多个洗涤孔，每个洗涤孔含有第一水溶液，和（e）具有透光底部的测量孔，测量孔包含第二 水溶液，其中样品孔，试剂阱，测量井和洗涤井的开口被密封。 本发明还涉及一种用于装载和释放探针的装置。 该装置包括推针和凹槽，以将探针加载并转移到多个位置，例如上述药筒中的不同的孔，以进行免疫测定。

    CROSSLINKED POLYSACCHARIDE
    9.
    发明申请
    CROSSLINKED POLYSACCHARIDE 审中-公开
    交联多糖

    公开(公告)号：US20140128596A1

    公开(公告)日：2014-05-08

    申请号：US13846517

    申请日：2013-03-18

    Applicant: ACCESS MEDICAL SYSTEMS, LTD.

    Inventor： Robert F. ZUK

    IPC: C08B37/00

    CPC classification number: G01N33/54366 ,  C08B37/006 ,  G01N21/6428 ,  G01N21/645 ,  G01N33/54373 ,  G01N2021/6439 ,  G01N2201/06113

    Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked FICOLL® molecule having a plurality of binding molecules and a plurality of fluorescent labels.

    Abstract translation: 本发明涉及一种用于在荧光测定中测量荧光信号的检测系统。 该系统包括具有与荧光标签结合的小感测表面的探针，以及安装在基底的感测表面的近侧的光源和检测器。 本发明还涉及一种使用具有小表面积（＆NlE; 5mm）的探针尖端和具有多个结合分子和多个荧光标记的高分子量聚合物（≥1MD）来检测液体样品中的分析物的方法。 通过横向流动反应溶液并在反应容器中上下移动探针尖端来加速结合反应。 本发明进一步涉及包含具有多个结合分子和多个荧光标记的交联FICOLL®分子的荧光标记组合物。

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