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公开(公告)号：US20210121875A1
公开(公告)日：2021-04-29
申请号：US17083126
申请日：2020-10-28
IPC分类号： B01L3/00
摘要： Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).
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公开(公告)号：US20240299939A1
公开(公告)日：2024-09-12
申请号：US18670099
申请日：2024-05-21
CPC分类号： B01L3/50273 , F04B43/1223 , G01N35/1009 , B01L2200/027 , B01L2300/0861 , B01L2300/123
摘要： Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).
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公开(公告)号：US12078596B2
公开(公告)日：2024-09-03
申请号：US16043651
申请日：2018-07-24
发明人： Jonathan M. Rothberg , Benjamin Cipriany , Todd Rearick , Paul E. Glenn , Faisal R. Ahmad , Todd Roswech , Brittany Lathrop , Thomas Connolly
IPC分类号： G01N21/64 , H01S5/00 , H01S5/02253 , H01S5/024 , H01S5/026
CPC分类号： G01N21/6486 , G01N21/6402 , G01N21/6408 , G01N21/6454 , H01S5/0071 , H01S5/02253 , H01S5/02461 , H01S5/0262 , G01N21/648 , G01N2021/6482 , G01N2201/0221 , G01N2201/0873
摘要： A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering assembly, bio-optoelectronic chip, and coupling optics register to an alignment structure in the instrument that can form at least one wall of an enclosure and dissipate heat.
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公开(公告)号：US12011716B2
公开(公告)日：2024-06-18
申请号：US17083106
申请日：2020-10-28
IPC分类号： G01N33/68 , A01N1/02 , B01L3/00 , C07C309/65 , C07C309/73 , F04B43/12 , G01N1/40 , G01N21/33 , G01N21/64 , G01N33/52 , G01N35/10
CPC分类号： B01L3/50273 , F04B43/1223 , G01N35/1009 , B01L2200/027 , B01L2300/0861 , B01L2300/123
摘要： Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).
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公开(公告)号：US20210121874A1
公开(公告)日：2021-04-29
申请号：US17083106
申请日：2020-10-28
摘要： Embodiments described herein generally relate to apparatuses, cartridges, and pumps for peristaltic pumping of fluids and associated methods, systems, and devices. The pumping of fluids is, in certain cases, an important aspect of a variety of applications, such as bioanalytical applications (e.g., biological sample analysis, sequencing, identification). The inventive features described herein may, in some embodiments, provide an ability to pump fluids in ways that combine certain advantages of robotic fluid handling systems (e.g., automation, programmability, configurability, flexibility) with certain advantages of microfluidics (e.g., small fluid volumes with high fluid resolution, precision, monolithic consumables, limiting of the wetting of components to consumables).
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公开(公告)号：US20190025214A1
公开(公告)日：2019-01-24
申请号：US16043651
申请日：2018-07-24
发明人： Jonathan M. Rothberg , Benjamin Cipriany , Todd Rearick , Paul E. Glenn , Faisal R. Ahmad , Todd Roswech , Brittany Lathrop , Thomas Connolly
摘要： A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering assembly, bio-optoelectronic chip, and coupling optics register to an alignment structure in the instrument that can form at least one wall of an enclosure and dissipate heat.
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