公开(公告)号：US11899028B2

公开(公告)日：2024-02-13

申请号：US17127178

申请日：2020-12-18

Applicant: Cytiva US LLC

Inventor： Michael B. Seal ,  Darren G. Elton ,  Bojan Isailovic ,  Jeremy Rautenbach

IPC: G01N35/00 ,  G01N35/10 ,  B01D15/08 ,  B01D65/00

CPC classification number: G01N35/00732 ,  G01N35/1009 ,  B01D15/08 ,  B01D65/00 ,  G01N2035/1025

Abstract: A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.

公开(公告)号：US20240142478A1

公开(公告)日：2024-05-02

申请号：US18405912

申请日：2024-01-05

Applicant: Cytiva US LLC

Inventor： Michael B. Seal ,  Darren G. Elton ,  Bojan Isailovic ,  Jeremy Rautenbach

IPC: G01N35/00 ,  G01N35/10

CPC classification number: G01N35/00732 ,  G01N35/1009 ,  B01D15/08

Abstract: A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.

公开(公告)号：US11814200B2

公开(公告)日：2023-11-14

申请号：US17934962

申请日：2022-09-23

Applicant: Cytiva US LLC

Inventor： Michael B. Seal ,  Bojan Isailovic ,  Robert Flisar ,  Jeremy Rautenbach

IPC: B67C3/22 ,  B65B3/00 ,  B65B3/12 ,  B65B3/34 ,  B65B55/24 ,  B67C3/28

CPC classification number: B65B3/003 ,  B65B3/12 ,  B65B3/34 ,  B65B55/24 ,  B67C3/225 ,  B67C3/282 ,  B67C2003/228

Abstract: A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.

公开(公告)号：US11787680B2

公开(公告)日：2023-10-17

申请号：US17934486

申请日：2022-09-22

Applicant: Cytiva US LLC

Inventor： Thomas J. Hartridge ,  Bojan Isailovic ,  Jens Bretschneider

IPC: B67C3/22 ,  B65B3/00 ,  B65B3/12 ,  B65B55/24 ,  B67C3/00 ,  B67C3/28

CPC classification number: B67C3/225 ,  B65B3/003 ,  B65B3/12 ,  B65B55/24 ,  B67C3/007 ,  B67C3/282 ,  B67C2003/228

Abstract: A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.