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公开(公告)号：US20240425903A1
公开(公告)日：2024-12-26
申请号：US18733814
申请日：2024-06-04
Applicant: CROSSLIFE TECHNOLOGIES INC.
Inventor： HyunDae Cho , Sharrol T. Bachas
IPC: C12Q1/6816 , C12N15/115 , C40B40/06
Abstract: The present invention relates to the field of protein engineering, molecular imaging, and molecular diagnostics. More particularly, provided herein are novel synthetic aptamers produced using the Gyrl-like family of proteins as a scaffold. Methods of obtaining and using the synthetic mutein aptamers are also provided.
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公开(公告)号：US12163164B2
公开(公告)日：2024-12-10
申请号：US16928915
申请日：2020-07-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Arkadiusz Bibillo , Pranav Patel
Abstract: Hybrid reverse transcriptases are provided that comprise a non-retroviral retrotransposon, or a fragment of the non-retroviral retrotransposon having reverse transcriptase activity, joined to a nucleic acid binding protein. Also provided are methods of using the hybrid reverse transcriptases to prepare a cDNA molecule library.
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公开(公告)号：US20240342678A1
公开(公告)日：2024-10-17
申请号：US18620775
申请日：2024-03-28
Applicant: Celldom, Inc. , The Regents of the University of California
Inventor： Natalia Tkachenko , Eugene Tkachenko , Alexander Groisman , Edgar Gutierrez
CPC classification number: B01J19/0046 , B01L3/5085 , C12N15/1013 , C12Q1/02 , C40B40/06 , G01N33/5005 , G01N33/54366 , B01J2219/00317 , B01J2219/005 , B01J2219/00648 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858
Abstract: The present invention provides methods, systems and kits for performing microwell analysis in sealed small volumes. The microwells of the invention are sealed through the pairing of microwell and bead geometry wherein the diameter of the beads is greater than the diameter of the bottom of the microwells. Loading the beads into the microwells seals samples within an analytical space between the bottom of a nested bead and the bottom of the subject microwell.
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公开(公告)号：US12116699B2
公开(公告)日：2024-10-15
申请号：US17812650
申请日：2022-07-14
Applicant: Impossible Foods Inc.
Inventor： Martin Andrew Hoyt , Xiao Guo , Smita Shankar
CPC classification number: C40B40/06 , C12N9/0006 , C12N15/1037 , C12N15/1086 , C12Y101/03013 , C12N15/815
Abstract: This document relates to materials and methods for the production of protein. In one aspect, this document provides a nucleic acid construct including a first alcohol oxidase promoter element, wherein the first alcohol oxidase promoter element includes a mutation at one or more nucleotide positions corresponding to any of nucleotide positions 668-734 relative to SEQ ID NO: 28.
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公开(公告)号：US12104201B2
公开(公告)日：2024-10-01
申请号：US17090792
申请日：2020-11-05
Applicant: CROSSLIFE TECHNOLOGIES INC.
Inventor： HyunDae Cho , Sharrol T. Bachas
IPC: C12Q1/6816 , C12N15/115 , C40B40/06
CPC classification number: C12Q1/6816 , C12N15/115 , C40B40/06
Abstract: The present invention relates to the field of protein engineering, molecular imaging, and molecular diagnostics. More particularly, provided herein are novel synthetic aptamers produced using the Gyrl-like family of proteins as a scaffold. Methods of obtaining and using the synthetic mutein aptamers are also provided.
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Patent Agency Ranking
公开(公告)号：US12071711B2
公开(公告)日：2024-08-27
申请号：US17470434
申请日：2021-09-09
Applicant: Illumina Cambridge Limited
Inventor： Niall Anthony Gormley , Geoffrey Paul Smith , David Bentley , Roberto Rigatti , Shujun Luo
IPC: C40B50/06 , C12N15/10 , C12Q1/6855 , C12Q1/686 , C40B40/06
CPC classification number: C40B50/06 , C12N15/1068 , C12N15/1093 , C12N15/1096 , C12Q1/6855 , C12Q1/686 , C40B40/06 , Y10T436/143333 , C12Q1/6855 , C12Q2565/525 , C12Q2525/313 , C12N15/1093 , C12Q2525/313 , C12Q2565/525
Abstract: The present invention relates to a method for preparing a library of template polynucleotides and use thereof in methods of solid-phase nucleic acid amplification. More specifically, the invention relates to a method for preparing a library of template polynucleotides that have common sequences at their 5′ ends and at their 3′ ends.
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公开(公告)号：US11999948B2
公开(公告)日：2024-06-04
申请号：US15970690
申请日：2018-05-03
Applicant: The Regents of the University of California
Inventor： Hugh E. Olsen , Miten Jain , Mark A. Akeson
IPC: C12Q1/6809 , C12N15/10 , C12N15/11 , C12Q1/6806 , C40B30/04 , C40B70/00 , C40B40/06
CPC classification number: C12N15/1065 , C12N15/1068 , C12N15/1093 , C12N15/11 , C12Q1/6806 , C40B30/04 , C40B70/00 , B01J2219/00454 , B01J2219/005 , B01J2219/00677 , B01J2219/00722 , B01J2219/00759 , C40B40/06 , C12N15/1093 , C12Q2537/159
Abstract: Provided are methods of producing size-selected nucleic acid libraries. The methods include contacting a nucleic acid sample and a nucleic acid binding reagent including an affinity tag, under conditions in which nucleic acids of less than a desired length are substantially bound to the nucleic acid binding reagent and nucleic acids of the desired length are substantially not bound to the nucleic acid binding reagent. The conditions include the duration of the contacting, the concentration of the nucleic acid binding reagent, or both. The methods further include separating, using the affinity tag, the nucleic acids of less than the desired length bound to the nucleic acid binding reagent from the nucleic acids of the desired length not bound to the nucleic acid binding reagent, to produce a size-selected nucleic acid library. Compositions and kits that find use, e.g., in practicing the methods of the present disclosure, are also provided.
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公开(公告)号：US11987904B2
公开(公告)日：2024-05-21
申请号：US16081635
申请日：2017-03-02
Applicant: Aptamer Group Limited
Inventor： Shuji Ikeda , Shozo Fujita , Tsuyoshi Fujihara
IPC: C40B40/06 , C12N15/10 , C12N15/115 , C40B40/08
CPC classification number: C40B40/08 , C12N15/1093 , C12N15/115 , C12N2310/16 , C12N2310/52 , C12N2320/11 , C12N2330/31
Abstract: Oligonucleotide constructs are described, each comprising a functional element and a coding element, wherein the functional element comprises a functional sequence, the functional sequence comprising a sequence of nucleotides in which one or more, or each, nucleotide is modified and the coding element comprises a coding sequence, the coding sequence comprising a sequence of nucleotides which do not contain the modifications of the functional sequence, wherein the coding sequence encodes the sequence structure of the functional sequence.
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公开(公告)号：US11970785B2
公开(公告)日：2024-04-30
申请号：US17460513
申请日：2021-08-30
Applicant: Base Pair Biotechnologies, Inc.
Inventor： George W. Jackson , Robert Batchelor , Alexander S. Chiu , Rafal Drabek , Deepak Thirunavukarasu , Caitlin Bruns
IPC: C07H21/04 , C12Q1/6811 , C12Q1/6837 , C40B40/06
CPC classification number: C40B40/06 , C12Q1/6811 , C12Q1/6837 , C12Q1/6811 , C12Q2525/205 , C12Q2525/301 , C12Q2537/143 , C12Q2563/159 , C12Q2565/101 , C12Q2565/501 , C12Q1/6837 , C12Q2525/205 , C12Q2525/301 , C12Q2537/143 , C12Q2563/159 , C12Q2565/101
Abstract: This invention relates to methods and materials for multiplexed utilization of collections of functional ligands, particularly to methods and materials for selecting for and/or utilizing particular desirable traits of functional ligands in a multiplexed manner, and more particularly to methods and materials for selecting for and/or utilizing particular structural changes of functional ligands in a multiplexed manner.
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公开(公告)号：US11932849B2
公开(公告)日：2024-03-19
申请号：US16677012
申请日：2019-11-07
Applicant: Cellular Research, Inc.
Inventor： Eleen Shum
CPC classification number: C12N15/1096 , C12N15/1006 , C40B40/06 , C40B50/04 , C40B50/06 , C40B70/00
Abstract: Disclosed herein include systems, methods, compositions, and kits for whole transcriptome analysis (WTA) with random priming and extension (RPE). The RPE-based WTA method can comprise hybridizing random primers with a plurality of first strand barcoded polynucleotides associated with a solid support and extending the random primers to generate a plurality of extension products. The method can comprise amplifying the plurality of extension products to generate a sequencing library.
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