公开(公告)号：US20240060961A1

公开(公告)日：2024-02-22

申请号：US18497955

申请日：2023-10-30

Applicant: The Regents of the University of California ,  CELLDOM, Inc.

Inventor： Eugene Tkachenko ,  Natalia Tkachenko ,  Edgar Gutierrez ,  Alexander Groisman

IPC: G01N33/50 ,  G01N33/543 ,  G01N33/58 ,  B01L3/00

CPC classification number: G01N33/5008 ,  G01N33/54306 ,  G01N33/585 ,  B01L3/5085 ,  G01N2500/02 ,  G01N2500/10 ,  B01L2300/021 ,  B01L3/50853 ,  B01L2200/0668 ,  B01L2300/123 ,  B01L2200/0689 ,  B01L2300/0893

Abstract: Provided are methods and compositions for cell-based drug screening with high-density arrays of conical microwells and slow-drug-release beads.

公开(公告)号：US11969702B2

公开(公告)日：2024-04-30

申请号：US15927057

申请日：2018-03-20

Applicant: Celldom, Inc. ,  The Regents of the University of California

Inventor： Natalia Tkachenko ,  Eugene Tkachenko ,  Alexander Groisman ,  Edgar Gutierrez

IPC: B01J19/00 ,  B01L3/00 ,  C12N15/10 ,  C12Q1/02 ,  C40B40/06 ,  G01N33/50 ,  G01N33/543

CPC classification number: B01J19/0046 ,  B01L3/5085 ,  C12N15/1013 ,  C12Q1/02 ,  C40B40/06 ,  G01N33/5005 ,  G01N33/54366 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00648 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858

Abstract: The present invention provides methods, systems and kits for performing microwell analysis in sealed small volumes. The microwells of the invention are sealed through the pairing of microwell and bead geometry wherein the diameter of the beads is greater than the diameter of the bottom of the microwells. Loading the beads into the microwells seals samples within an analytical space between the bottom of a nested bead and the bottom of the subject microwell.

公开(公告)号：US20240409997A1

公开(公告)日：2024-12-12

申请号：US18699868

申请日：2022-10-10

Applicant: Celldom, Inc.

Inventor： Eugene TKACHENKO

IPC: C12Q1/6874 ,  C12Q1/6806

Abstract: The invention provides a method of barcoding microparticles with fluorescent moieties. The fluorescent moieties are linked to the microparticles by variable cleavable linkers. The combination of fluorescent moieties and variable cleavable linkers provides microparticles having an exponentially expandable number of fluorescent barcodes that can be manufactured and decoded in a sequential manner. The fluorescent barcodes can be used to identify microwells, cells, chemicals and oligonucleotides in wide variety of high throughput assay applications.

公开(公告)号：US20240342678A1

公开(公告)日：2024-10-17

申请号：US18620775

申请日：2024-03-28

Applicant: Celldom, Inc. ,  The Regents of the University of California

Inventor： Natalia Tkachenko ,  Eugene Tkachenko ,  Alexander Groisman ,  Edgar Gutierrez

IPC: B01J19/00 ,  B01L3/00 ,  C12N15/10 ,  C12Q1/02 ,  C40B40/06 ,  G01N33/50 ,  G01N33/543

CPC classification number: B01J19/0046 ,  B01L3/5085 ,  C12N15/1013 ,  C12Q1/02 ,  C40B40/06 ,  G01N33/5005 ,  G01N33/54366 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00648 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858

Abstract: The present invention provides methods, systems and kits for performing microwell analysis in sealed small volumes. The microwells of the invention are sealed through the pairing of microwell and bead geometry wherein the diameter of the beads is greater than the diameter of the bottom of the microwells. Loading the beads into the microwells seals samples within an analytical space between the bottom of a nested bead and the bottom of the subject microwell.