公开(公告)号：US11691142B2

公开(公告)日：2023-07-04

申请号：US17064532

申请日：2020-10-06

Applicant: CA CASYSO GmbH

Inventor： Michael M. Gorin ,  Robert S. Hillman ,  Cory Lee McCluskey ,  Hubert Martin Schwaiger

IPC: B01L3/00 ,  G01N33/86 ,  G01N35/00 ,  G01N15/06 ,  B01L7/00 ,  G01N15/00

CPC classification number: B01L3/502 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/527 ,  B01L7/00 ,  G01N15/0656 ,  G01N33/86 ,  G01N35/00722 ,  B01L2200/0689 ,  B01L2200/147 ,  B01L2300/041 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0867 ,  B01L2300/123 ,  B01L2300/161 ,  B01L2400/0633 ,  B01L2400/0638 ,  G01N2015/0084 ,  G01N2015/0092 ,  G01N2035/0091 ,  G01N2035/00356

Abstract: Embodiments of a platelet testing system include an analyzer console device and a blood testing cartridge configured to releasably install into the console device. The cartridge device is configured with one or more measuring chambers and one or more mixing chambers that are fluidically connected within the cartridge device that enable the mixing of saline and a blood sample to a desired dilution. Additionally, the cartridge device is further configured with a cartridge slider that provides a reagent bead to the saline and blood mixture at a desired time. As such, one or more platelet activation assays can be conducted by measuring, through cartridge electrodes of the cartridge device, the detectable changes in platelet activity within the blood and saline mixture.

公开(公告)号：US20190250176A1

公开(公告)日：2019-08-15

申请号：US16319412

申请日：2017-07-25

Applicant: QORVO US, INC.

Inventor： Florian Bell ,  Bruce Murdock

IPC: G01N33/86 ,  G01N15/06 ,  G01N29/02 ,  G01N29/036 ,  G01N33/49

CPC classification number: G01N33/86 ,  B01L3/502715 ,  B01L2300/023 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0436 ,  G01N11/10 ,  G01N11/16 ,  G01N15/0637 ,  G01N29/022 ,  G01N29/036 ,  G01N29/222 ,  G01N30/96 ,  G01N33/4905 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2203/0089 ,  G01N2203/0092 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/0426 ,  G01N2291/106

Abstract: Sensors employing bulk acoustic wave (BAW) resonators are used to assay characteristics of blood. The BAW sensors may be used to sense viscosity of a sample comprising blood to determine coagulation properties of the blood. The viscosity of the blood may be evaluated in the presence of agents that inhibit coagulation or that promote coagulation. The change in viscosity of the sample in the presence of such agents may provide information regarding whether the blood suffers from a coagulation disorder.

公开(公告)号：US09983220B2

公开(公告)日：2018-05-29

申请号：US14655437

申请日：2013-12-26

Applicant: Korea University Research and Business Foundation

Inventor： Se Hyun Shin ,  Chae Seung Lim

IPC: G01N33/86 ,  G01N33/49 ,  G01N15/14 ,  B01L3/00 ,  G01N15/06 ,  C12M3/00 ,  G01N15/00

CPC classification number: G01N33/86 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2400/0406 ,  B01L2400/0478 ,  B01L2400/06 ,  G01N15/0612 ,  G01N15/1463 ,  G01N15/1484 ,  G01N33/49 ,  G01N2015/0092

Abstract: The present invention relates to an apparatus and a method for testing a function and a drug response of a platelet based on a microfluidic chip. The apparatus for test comprises a measuring device containing a blood sample and measuring aggregation and adhesion of a platelet generated by flow of the blood sample; and a fluid driving device which is connected to the measuring device and generates a oscillating shear flow of the blood sample. Therefore, activation of factors such as a platelet and von Willebrand factor (vWF) etc. can be activated uniformly and completely, and a repeatability of the platelet aggregation can be increased.

公开(公告)号：US20180119195A1

公开(公告)日：2018-05-03

申请号：US15792572

申请日：2017-10-24

Applicant: Nexcelom Bioscience LLC

Inventor： Leo L. Chan ,  Jean Qiu ,  Peter Li ,  Kevin Flanagan

IPC: C12Q1/02 ,  G01N21/64

CPC classification number: C12Q1/02 ,  C12N1/16 ,  G01N15/1475 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2015/1497 ,  G01N2021/6441 ,  G01N2333/395

Abstract: The invention generally relates to analyzing yeast viability and reproduction rate of yeasts. More particularly, the invention relates to efficient and effective methods and compositions for accessing and measuring budding percentages, viability and concentration of yeast cells.

公开(公告)号：US09863857B2

公开(公告)日：2018-01-09

申请号：US14448141

申请日：2014-07-31

Applicant: INTEL CORPORATION

Inventor： Xing Su ,  David J. Liu ,  Kai Wu ,  Kenneth B. Swartz ,  Mineo Yamakawa

IPC: G01N1/40 ,  G01N35/08 ,  B01L3/00 ,  G01N35/00 ,  G01N15/00 ,  H01F7/20 ,  H01F7/06

CPC classification number: G01N1/4044 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2400/0424 ,  B01L2400/043 ,  B01L2400/0638 ,  B01L2400/086 ,  G01N35/0098 ,  G01N35/08 ,  G01N2015/0038 ,  G01N2015/0092 ,  H01F7/20 ,  H01F7/206 ,  H01F2007/068 ,  Y10S436/805 ,  Y10S436/806 ,  Y10T29/49117 ,  Y10T29/4913 ,  Y10T29/49155 ,  Y10T436/25

Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

公开(公告)号：US09857352B2

公开(公告)日：2018-01-02

申请号：US15041527

申请日：2016-02-11

Applicant: Sinnowa Medical Science & Technology Co., Ltd.

Inventor： Xin Xu ,  Ziquan Dong ,  Ning Cao ,  Xiang Li ,  Fan Yu ,  Weijie Yang

IPC: G01N33/86 ,  G01N15/10 ,  G01N33/49 ,  G01N35/10 ,  A61B5/15 ,  A61B5/155 ,  A61B5/153 ,  A61B5/157 ,  G01N35/00 ,  G01N15/00

CPC classification number: G01N33/49 ,  A61B5/1405 ,  A61B5/1427 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  G01N15/10 ,  G01N33/86 ,  G01N35/1004 ,  G01N35/1065 ,  G01N2015/0084 ,  G01N2015/0092 ,  G01N2015/1062 ,  G01N2035/00534 ,  G01N2035/00544

Abstract: An automated platelet function analyzer includes a sampling vessel, a preparation vessel, an analysis vessel, a sampling needle, a blood sample syringe, an analysis solution syringe, and a blood mixing device. A method for platelet analysis is also disclosed.

公开(公告)号：US20170307626A1

公开(公告)日：2017-10-26

申请号：US15519490

申请日：2015-10-15

Applicant: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

Inventor： Andrew David GRIFFITHS ,  Raphaël Clément Li-Ming DOINEAU ,  Clément NIZAK ,  Philippe Chi-Thanh NGHE ,  Jean Marie Pierre BAUDRY ,  Elodie Michèle Christine BRIENT-LITZLER

IPC: G01N33/68 ,  B01L3/00 ,  G01N33/543 ,  C12Q1/68 ,  G01N15/00

CPC classification number: G01N33/68 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0668 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0487 ,  C12Q1/6846 ,  G01N33/543 ,  G01N2015/003 ,  G01N2015/0092 ,  C12Q1/6816 ,  C12Q2563/149 ,  C12Q2563/159

Abstract: The invention concerns a method of analyzing the content of drops, involving then following step: providing a plurality of drops (6) contained in a carrier fluid, at least one of the drops (6) comprising at least one aggregate (10) of particles defining an object extending along a main axis, at least some of the drops (6) containing at least one target element capable of attaching to the aggregate (10). The method involves a step in which a physical parameter characteristic of the attachment of the target element to the aggregate (10) is measured.

公开(公告)号：US09696293B2

公开(公告)日：2017-07-04

申请号：US15003272

申请日：2016-01-21

Applicant: Alcor Scientific, Inc.

Inventor： Peter Sacchetti ,  Francesco Frappa

IPC: G01N33/49 ,  G01N21/51 ,  G01N15/05 ,  G01N15/00

CPC classification number: G01N33/4905 ,  G01N15/05 ,  G01N21/51 ,  G01N33/4915 ,  G01N2015/0073 ,  G01N2015/0092

Abstract: Systems and methods for the determination of the aggregation rate of red blood cells. More specifically, the subject technology is used to determine the aggregation rate of red blood cells, and other parameters related to these, such as viscosity, deformability, elasticity, density, in the field of in vitro medical analyses, using optical systems after or during vibration for red blood cell disruption and redistribution. Once the detected light variation stops decreasing (e.g., a minimum is reached), complete disruption is accomplished for evaluation of the blood sample.

公开(公告)号：US09658156B2

公开(公告)日：2017-05-23

申请号：US13578593

申请日：2011-02-25

Applicant: Michael I. Larkin

Inventor： Amy D. Hanlon ,  Michael I. Larkin

IPC: G01N21/00 ,  G01N21/49 ,  G01N21/47 ,  G01N15/14 ,  G01N15/02 ,  G01N15/00

CPC classification number: G01N21/49 ,  G01N15/0211 ,  G01N15/1429 ,  G01N15/1434 ,  G01N21/4738 ,  G01N2015/0038 ,  G01N2015/0092 ,  G01N2015/0216 ,  G01N2015/0222 ,  G01N2201/06113 ,  G01N2201/12

Abstract: This invention enables high throughput detection of small molecule effectors of particle association, as well as quantification of association constants, stoichiometry, and conformation. Given a set of particle solutions having different concentrations, dynamic light scattering measurements are used to determine the average hydrodynamic radius, as a function of concentration. The series of average hydrodynamic radii as a function of concentration are fitted with stoichiometric association models containing the parameters of molar mass, modeled concentrations, and modeled hydrodynamic radii of the associated complexes. In addition to the average hydrodynamic radii value analysis, the experimental data may be fit/analyzed in alternate ways. This method may be applied to a single species that is self-associating or to multiple species that are hetero-associating. This method may also be used to characterize and quantify the association between a modulator and the associating species.

公开(公告)号：US20160326030A1

公开(公告)日：2016-11-10

申请号：US15216901

申请日：2016-07-22

Applicant: METAWATER CO., LTD.

Inventor： Yuka YAMAGUCHI ,  Yusuke HISAMOTO ,  Hiroshi MUNEHIRA ,  Shigeyuki OKADA ,  Dabide YAMAGUCHI

IPC: C02F1/52 ,  B01D21/01 ,  B01D21/30

CPC classification number: C02F1/5209 ,  B01D21/01 ,  B01D21/08 ,  B01D21/30 ,  C02F2209/001 ,  C02F2209/003 ,  C02F2209/006 ,  C02F2209/105 ,  G01N15/02 ,  G01N2015/0092

Abstract: Provided is a water treatment system that prevents overlook and misdetection of abnormal flocculation. The water treatment system includes a mix tank, a flocculation tank, a plurality of floc-particle-diameter measurement devices, a fault detection device that detects abnormal flocculation, and a notification device that notifies occurrence of the abnormal flocculation. The fault detection device includes: a calculator that calculates at least one of a difference and a ratio between particle diameters of floc; a storage that stores therein a tolerable range of at least one of the difference and the ratio between the particle diameters of floc; a determiner that, when the calculated value is within the tolerable range, determines that it is normal, and when the calculated value is outside the tolerable range, determines that it is abnormal; and an outputter that transmits an abnormal flocculation detection signal to the notification device.

Abstract translation: 提供了防止异常絮凝的忽视和误检的水处理系统。 水处理系统包括混合罐，絮凝槽，多个絮凝粒径测量装置，检测异常絮凝的故障检测装置，以及通知异常絮凝发生的通知装置。 所述故障检测装置包括：计算器，其计算絮体的粒径之间的差异和比例中的至少一个; 其中存储有其中絮体的粒径之间的差异和比率之间的至少一个的可容许范围的容许范围; 当计算值在可容忍范围内时，确定它是正常的，当计算值在可容忍范围之外时，确定它是异常的; 以及将异常絮凝检测信号发送到通知装置的输出器。