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    PARTICLE MANIPULATION SYSTEM WITH CYTOMETRIC CAPABILITY AND FEEDBACK LOOP AND VARIABLE GAIN DETECTOR
    1.
    发明公开
    PARTICLE MANIPULATION SYSTEM WITH CYTOMETRIC CAPABILITY AND FEEDBACK LOOP AND VARIABLE GAIN DETECTOR 审中-公开

    公开(公告)号：US20240067920A1

    公开(公告)日：2024-02-29

    申请号：US18238614

    申请日：2023-08-28

    Applicant: Owl biomedical, Inc.

    Inventor： Paul Hing ,  Nathaniel BAIR ,  Daryl GRUMMITT ,  John Harley ,  Mark NAIVAR ,  Matthew DICKERSON

    IPC: C12M1/00 ,  G01N15/14

    CPC classification number: C12M47/04 ,  G01N15/1459 ,  G01N2015/1081

    Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. One or more feedback loops may be used to improve the particle manipulation process, based on data acquired during the first interrogation and/or during a downstream confirmation. Artificial intelligence techniques may be used to good effect. A variable gain detector may improve the speed and sensitivity of the system.

    PARTICLE MANIPULATION SYSTEM WITH CYTOMETRIC CAPABILITY AND FEEDBACK LOOP
    2.
    发明申请
    PARTICLE MANIPULATION SYSTEM WITH CYTOMETRIC CAPABILITY AND FEEDBACK LOOP 有权

    公开(公告)号：US20230124069A1

    公开(公告)日：2023-04-20

    申请号：US17500986

    申请日：2021-10-14

    Applicant: Owl biomedical, Inc.

    Inventor： Daryl GRUMMITT ,  Mehran Hoonejani ,  Kevin SHIELDS ,  John HARLEY ,  Matthew MASON ,  Mark NAIVAR

    IPC: B01L3/00 ,  G01N15/14

    Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and a plurality of laser interrogation regions. The laser interrogation regions may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, flap-type fluid valve, which sorts a target particle from non-target particles in a fluid stream. The laser interrogation stages are disposed in the microfabricated fluid channels at the input and output of the flap-type sorting valve. The laser interrogation regions may be used to assess the effectiveness or accuracy of the sorting, and to control or adjust sort parameters during the sorting process. One or more feedback loops may be used to improve the particle manipulation process, based on data acquired during the first interrogation and/or during a downstream confirmation. Artificial intelligence techniques may be used to good effect.

    MICROFABRICATED DROPLET DISPENSOR WITH IMMISCIBLE FLUID
    3.
    发明申请
    MICROFABRICATED DROPLET DISPENSOR WITH IMMISCIBLE FLUID 审中-公开

    公开(公告)号：US20190381506A1

    公开(公告)日：2019-12-19

    申请号：US16009163

    申请日：2018-06-14

    Applicant: Owl biomedical, Inc.

    Inventor： John S FOSTER ,  Mehran Hoonejani ,  Kevin SHIELDS

    IPC: B01L3/00

    Abstract: A microfabricated droplet dispensing structure is described, which may include a MEMS microfluidic fluidic valve, configured to open and close a microfluidic channel. The opening and closing of the valve may separate a target particle and a bead from a sample stream, and direct these two particle into a single droplet formed at the edge of the substrate. The droplet may then be encased in a sheath flow of an immiscible fluid.

    MEMS-BASED SINGLE PARTICLE SEPARATION SYSTEM
    9.
    发明申请
    MEMS-BASED SINGLE PARTICLE SEPARATION SYSTEM 有权
    基于MEMS的单颗粒分离系统

    公开(公告)号：US20150253223A1

    公开(公告)日：2015-09-10

    申请号：US14275974

    申请日：2014-05-13

    Applicant: OWL BIOMEDICAL, INC.

    Inventor： John S. FOSTER ,  Nicholas C. MARTINEZ

    IPC: G01N1/30 ,  G01N1/31

    CPC classification number: G01N1/31 ,  B01L3/0241 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0663 ,  B01L2300/0864 ,  B01L2400/0622 ,  B01L2400/0644 ,  G01N1/30

    Abstract: A particle separation system uses a MEMS-based, microfabricated particle manipulation device which has an inlet channel, output channels, and a movable member formed on a substrate to sort one or more target particle from a sample stream. The system may include an interposer that receives the sorted particle and dispenses a carrier fluid with it to form a liquid droplet containing the particle. The droplet may then be dispensed to a microtiter plate, such that each well in the titer plate may contain a single target particle. The system may be used to separate individual biological cells, such as T cells, B cells, stem cells, cancer cells and sperm cells for further manipulation.

    Abstract translation: 颗粒分离系统使用具有入口通道，输出通道和形成在基板上的可移动部件的基于MEMS的微加工的颗粒操纵装置，以从样品流中分离一个或多个目标颗粒。 该系统可以包括插入器，其接收分选的颗粒并且分配载体流体以形成含有颗粒的液滴。 然后可以将液滴分配到微量滴定板，使得滴定板中的每个孔可以包含单个靶颗粒。 该系统可以用于分离各种生物细胞，例如T细胞，B细胞，干细胞，癌细胞和精子细胞，用于进一步的操作。

    PARTICLE MANIPULATION SYSTEM WITH CAMERA/CLASSIFIER CONFIRMATION AND DEEP LEARNING ALGORITHM
    10.
    发明公开
    PARTICLE MANIPULATION SYSTEM WITH CAMERA/CLASSIFIER CONFIRMATION AND DEEP LEARNING ALGORITHM 审中-公开

    公开(公告)号：US20240272062A1

    公开(公告)日：2024-08-15

    申请号：US18438518

    申请日：2024-02-12

    Applicant: Owl biomedical, inc.

    Inventor： Daryl GRUMMITT

    IPC: G01N15/149 ,  G01N15/10

    CPC classification number: G01N15/149 ,  G01N15/1012 ,  G01N2015/1026

    Abstract: A MEMS-based particle manipulation system which uses a particle manipulation stage and optical confirmation of the manipulation. The optical confirmation may be camera-based, and may be used to assess the effectiveness or accuracy of the particle manipulation stage. In one exemplary embodiment, the particle manipulation stage is a microfabricated, fluid valve, which sorts a target particle from non-target particles in a fluid stream. The optical confirmation stage is disposed in the microfabricated fluid channels at the input and output of the microfabricated sorting valve. Deep learning techniques are brought to bear on the camera output to increase speed, accuracy and reliability. A calibration device may make use of a pixelated emitter, an optical filter and a spectral separator to mimic the fluorescent output of a biological sample tagged with fluorescent emitters as used in the particle sorting system. This calibration device may allow quick and easy calibration of the optical system for improved speed and performance.

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