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    Fluid injection
    1.
    发明授权
    Fluid injection 有权

    公开(公告)号：US11358105B2

    公开(公告)日：2022-06-14

    申请号：US17145684

    申请日：2021-01-11

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

    IPC: B01F25/314 ,  F16K99/00 ,  B01J19/00 ,  B01L3/00 ,  B01F33/302 ,  B01F33/3031 ,  G01N27/447 ,  G01N35/10

    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    Electronic control of fluidic species
    9.
    发明授权
    Electronic control of fluidic species 有权

    公开(公告)号：US11383234B2

    公开(公告)日：2022-07-12

    申请号：US16813106

    申请日：2020-03-09

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Darren Roy Link ,  Galder Cristobal-Azkarate ,  Zhengdong Cheng ,  Keunho Ahn

    IPC: B01L3/00 ,  B01J19/00 ,  G01N15/14 ,  B01F33/30 ,  B01F33/302 ,  B01F33/3031 ,  G01N15/10 ,  B01F25/45 ,  B01F25/433 ,  B01F25/452 ,  B01F25/23 ,  B01L3/02

    Abstract: Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.

    DIRECTING MOTION OF DROPLETS USING DIFFERENTIAL WETTING
    10.
    发明申请
    DIRECTING MOTION OF DROPLETS USING DIFFERENTIAL WETTING 有权

    公开(公告)号：US20250065326A1

    公开(公告)日：2025-02-27

    申请号：US18624968

    申请日：2024-04-02

    Applicant: Volta Labs, Inc.

    Inventor： Udayan UMAPATHI

    IPC: B01L3/00 ,  B01F33/302 ,  B01F33/3031 ,  B01F101/23 ,  G02B26/00 ,  H05K3/28

    Abstract: Apparatus for controlling motion of liquid droplets. A set of electrode pads is arranged to define one or more tracks over which liquid droplets may be induced to move over a sequence of the electrode pads. A surface over the electrode pads is dielectric, smooth, and slippery to the droplets. In some cases, the smooth surface is formed as a thin layer of a second liquid that is immiscible with the liquid of the droplets. The surface has wetting affinity to the liquid that can be individually varied in a controlled manner by application of voltage to respective electrode pads. A control is designed to alter the wetting characteristic of varying-wettability portions of the surface over respective electrode pads to effect induced motion of the droplets over the surface. The apparatus is designed with the smooth hydrophobic surface open, with no overlying or facing electrode or plate above the droplets.

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