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    Fluid injection
    1.
    发明授权
    Fluid injection 有权

    公开(公告)号：US11358105B2

    公开(公告)日：2022-06-14

    申请号：US17145684

    申请日：2021-01-11

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

    IPC: B01F25/314 ,  F16K99/00 ,  B01J19/00 ,  B01L3/00 ,  B01F33/302 ,  B01F33/3031 ,  G01N27/447 ,  G01N35/10

    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    FLUID INJECTION
    4.
    发明申请
    FLUID INJECTION 有权

    公开(公告)号：US20220274072A1

    公开(公告)日：2022-09-01

    申请号：US17745711

    申请日：2022-05-16

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

    IPC: B01F25/314 ,  F16K99/00 ,  B01J19/00 ,  B01L3/00 ,  B01F33/302 ,  B01F33/3031

    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    FLUID INJECTION
    5.
    发明申请
    FLUID INJECTION 有权

    公开(公告)号：US20210197146A1

    公开(公告)日：2021-07-01

    申请号：US17145684

    申请日：2021-01-11

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

    IPC: B01F5/04 ,  F16K99/00 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00

    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    Fluid injection
    6.
    发明授权
    Fluid injection 有权

    公开(公告)号：US10919008B2

    公开(公告)日：2021-02-16

    申请号：US15659307

    申请日：2017-07-25

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

    IPC: B01F5/04 ,  F16K99/00 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N27/447 ,  G01N35/10

    Abstract: The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

    SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
    7.
    发明申请
    SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING 审中-公开

    公开(公告)号：US20180057875A1

    公开(公告)日：2018-03-01

    申请号：US15670885

    申请日：2017-08-07

    Applicant: President and Fellows of Harvard College

    Inventor： David A. Weitz ,  Jeremy Agresti ,  Michael P. Weiner ,  Adam R. Abate ,  Tony Hung

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q2537/143 ,  C12Q2563/149

    Abstract: The present invention relates to systems and methods for sequencing nucleic acids, including sequencing nucleic acids in fluidic droplets. In one set of embodiments, the method employs sequencing by hybridization using droplets such as microfluidic droplets. In some embodiments, droplets are formed which include a target nucleic acid, a nucleic acid probe, and at least one identification element, such as a fluorescent particle. The nucleic acid probes that hybridize to the target nucleic acid are determined, in some instances, by determining the at least one identification element. The nucleic acid probes that hybridize to the target nucleic acid may be used to determine the sequence of the target nucleic acid. In certain instances, the microfluidic droplets are provided with reagents that modify the nucleic acid probe. In some cases, a droplet, such as those described above, is deformed such that the components of the droplets individually pass a target area.

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