公开(公告)号：US20230302420A1

公开(公告)日：2023-09-28

申请号：US17978304

申请日：2022-11-01

申请人： President and Fellows of Harvard College

发明人： David A. Weitz ,  Mark Romanowsky ,  Adam R. Abate

IPC分类号： B01F33/3011 ,  B01L3/00 ,  B01F23/41 ,  B01J19/00

CPC分类号： B01F33/3011 ,  B01L3/502784 ,  B01F23/41 ,  B01F23/4105 ,  B01J19/0093 ,  Y10T137/8593 ,  B01J2219/00015 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0097 ,  B01J2219/00975 ,  B01F2101/23

摘要： Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

公开(公告)号：US20190062502A1

公开(公告)日：2019-02-28

申请号：US16149867

申请日：2018-10-02

申请人： The Boeing Company

发明人： Patrick John Kinlen ,  Andrew M. Zweig

IPC分类号： C08G73/02 ,  B01J19/24 ,  B01J19/00 ,  C09D179/02

CPC分类号： C08G73/0266 ,  B01J19/0093 ,  B01J19/2415 ,  B01J19/242 ,  B01J19/2425 ,  B01J19/243 ,  B01J2219/00087 ,  B01J2219/00164 ,  B01J2219/00795 ,  B01J2219/00822 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00963 ,  B01J2219/24 ,  C09D179/02

摘要： A flow reactor system and methods having tubing useful as polymerization chamber. The flow reactor has at least one inlet and at least one mixing chamber, and an outlet. The method includes providing two phases, an aqueous phase and a non-aqueous phase and forming an emulsion for introduction into the flow reactor.

公开(公告)号：US20170354937A1

公开(公告)日：2017-12-14

申请号：US15659307

申请日：2017-07-25

申请人： President and Fellows of Harvard College

发明人： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

IPC分类号： B01F5/04 ,  B01L3/00 ,  B01F13/00 ,  B01J19/00 ,  F16K99/00 ,  G01N35/10 ,  G01N27/447

CPC分类号： B01F5/0471 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00837 ,  B01J2219/00853 ,  B01J2219/00862 ,  B01J2219/00889 ,  B01L3/50273 ,  B01L3/502784 ,  B01L2300/0867 ,  B01L2400/0415 ,  F16K99/0042 ,  F16K99/0051 ,  G01N27/44791 ,  G01N2035/1034 ,  Y10T137/0391 ,  Y10T137/206

摘要： The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

公开(公告)号：US09757698B2

公开(公告)日：2017-09-12

申请号：US13379782

申请日：2010-06-25

申请人： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

发明人： David A. Weitz ,  Adam R. Abate ,  Tony Hung ,  Pascaline Mary

IPC分类号： F16K99/00 ,  B01F5/04 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  G01N27/447 ,  G01N35/10

CPC分类号： B01F5/0471 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00837 ,  B01J2219/00853 ,  B01J2219/00862 ,  B01J2219/00889 ,  B01L3/50273 ,  B01L3/502784 ,  B01L2300/0867 ,  B01L2400/0415 ,  F16K99/0042 ,  F16K99/0051 ,  G01N27/44791 ,  G01N2035/1034 ,  Y10T137/0391 ,  Y10T137/206

摘要： The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

公开(公告)号：US09592506B2

公开(公告)日：2017-03-14

申请号：US14517602

申请日：2014-10-17

申请人： The University of Chicago

发明人： Rustem F. Ismagilov ,  Joshua David Tice ,  Cory John Gerdts ,  Bo Zheng

IPC分类号： G01N1/10 ,  B01L3/00 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00 ,  B82Y30/00 ,  G01N35/08 ,  G01N1/28 ,  B01D9/00 ,  C07K14/43 ,  C12N9/36 ,  C30B7/14 ,  C30B29/54 ,  C30B29/58 ,  B01J14/00 ,  C12Q1/68

CPC分类号： B01L3/502784 ,  B01D9/0072 ,  B01D2009/0086 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0071 ,  B01J14/00 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00736 ,  B01J2219/00756 ,  B01J2219/00783 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00869 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00894 ,  B01J2219/00903 ,  B01J2219/00975 ,  B01J2219/00977 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2300/0867 ,  B01L2400/0487 ,  B82Y30/00 ,  C07K14/43 ,  C12N9/2462 ,  C12Q1/6806 ,  C12Y302/01017 ,  C30B7/14 ,  C30B29/54 ,  C30B29/58 ,  G01N1/28 ,  G01N35/08 ,  Y10T117/10 ,  Y10T137/0318 ,  Y10T436/117497 ,  Y10T436/143333 ,  Y10T436/25

摘要： A method of crystallization is disclosed, the method comprises the steps of providing a microfluidic system comprising at least three channels having at least one junction; providing within the at least three channels a continuously flowing water-immiscible carrier-fluid, a continuously flowing first aqueous fluid comprising a crystallization target, and a continuously flowing second aqueous fluid comprising a precipitant; forming at least one plug comprising the first and second aqueous fluids by partitioning the aqueous fluids with the flowing carrier-fluid at the junction of the at least three channels, flowing the at least one plug through an outlet port into a tubing, and stopping the flow of the at least one plug in the tubing, wherein the crystallization target forms a crystal in the tubing.

摘要翻译： 公开了一种结晶方法，该方法包括提供包含至少三个通道的微流体系统的步骤，该通道具有至少一个结点; 在所述至少三个通道内提供连续流动的与水不混溶的载体流体，包含结晶靶的连续流动的第一含水流体和包含沉淀剂的连续流动的第二含水流体; 通过在所述至少三个通道的接合处分配含水流体与所述流动的载体流体形成至少一个塞子，所述至少一个塞子使所述至少一个塞子通过出口端口流入管道，并且停止 管中的至少一个塞子的流动，其中结晶靶在管道中形成晶体。

公开(公告)号：US09566558B2

公开(公告)日：2017-02-14

申请号：US11662362

申请日：2005-09-09

申请人： Jean-Louis Viovy ,  Max Chabert ,  Kevin Dorfman

发明人： Jean-Louis Viovy ,  Max Chabert ,  Kevin Dorfman

IPC分类号： C12M1/00 ,  C12Q1/68 ,  C02F1/40 ,  G01N15/06 ,  G01N33/48 ,  G01N27/00 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  F04B19/00 ,  G01N35/08 ,  B01L7/00 ,  G01N15/00 ,  G01N35/10

CPC分类号： B01L3/502784 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00853 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0097 ,  B01L3/5027 ,  B01L3/502723 ,  B01L7/525 ,  B01L2200/0605 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/1816 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0415 ,  B01L2400/0427 ,  B01L2400/0493 ,  C12Q1/686 ,  F04B19/006 ,  G01N35/08 ,  G01N2015/003 ,  G01N2015/0053 ,  G01N2035/1037

摘要： The present invention concerns a microfluidic device (1) for performing physical, chemical or biological treatment to at least one packet without contamination.

摘要翻译： 本发明涉及用于对至少一个包进行物理，化学或生物处理而不被污染的微流体装置（1）。

公开(公告)号：US09486757B2

公开(公告)日：2016-11-08

申请号：US14710223

申请日：2015-05-12

申请人： President and Fellows of Harvard College

发明人： Mark Romanowsky ,  Adam R. Abate ,  David A. Weitz

IPC分类号： G01N1/10 ,  B01L3/00 ,  B01F13/00 ,  B01F3/08 ,  B01J19/00

CPC分类号： B01F13/0062 ,  B01F3/0807 ,  B01F3/0811 ,  B01F2215/0037 ,  B01J19/0093 ,  B01J2219/00015 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0097 ,  B01J2219/00975 ,  B01L3/502784 ,  B01L2200/0636 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0861 ,  Y10T137/0318 ,  Y10T137/8593

摘要： Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

摘要翻译： 描述了用于在流体中聚焦和/或形成相似或不同尺寸的不连续部分的微流体方法和装置的并行使用。 在一些方面，本发明一般涉及流动聚焦型技术，还涉及微流体，更具体地说，并行使用布置成控制分散剂内的分散相的微流体系统，以及尺寸和尺寸分布 分散相在多相流体系统中，以及用于将流体组分输送到多个这样的装置的系统。

公开(公告)号：US09421284B2

公开(公告)日：2016-08-23

申请号：US14235005

申请日：2012-12-26

申请人： Hitachi, Ltd.

发明人： Nami Sugita ,  Naomi Manri ,  Wataru Takeuchi ,  Yuichi Morimoto ,  Hiroko Hanzawa

IPC分类号： B01J19/24 ,  A61K51/08 ,  B01J19/00 ,  B01L3/00 ,  B01F13/00 ,  C07B59/00

CPC分类号： A61K51/088 ,  B01F13/0062 ,  B01F13/0066 ,  B01J19/0006 ,  B01J19/0093 ,  B01J19/24 ,  B01J2219/00049 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00842 ,  B01J2219/00873 ,  B01J2219/0088 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2219/24 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  C07B59/00 ,  Y10T436/12

摘要： A reaction container in which to mix a first chemical compound with a second chemical compound has a main body and a lid member formed oppositely on a top face side of the main body; a flow channel on the top face of the main body; and a labeling agent solidification section at an intermediate section of the flow channel to remove a solvent in a solution of the second chemical compound and solidify the second chemical compound. First and second chemical compound supply sections and a mixture discharge section are formed on the upstream and downstream sides of the labeling agent solidification section, respectively. The reactor is provided with a liquid sending unit to supply the first and second chemical compounds and reciprocally send a solution of the first chemical compound to an upper part of the second chemical compound solidified at the solidification section.

摘要翻译： 将第一化合物与第二化合物混合的反应容器具有主体和在主体的顶面相对地形成的盖部件; 主体顶面上的流路; 以及在流路的中间部分处的标记剂固化部分，以除去第二化合物的溶液中的溶剂并固化第二化合物。 分别在标签试剂凝固部的上游侧和下游侧形成第一和第二化合物供给部和混合物排出部。 反应器设有一个送液单元，用于供应第一和第二化合物，并将第一化合物的溶液往凝固段固化的第二化合物的上部相互转移。

公开(公告)号：US09339755B2

公开(公告)日：2016-05-17

申请号：US14795784

申请日：2015-07-09

申请人： Chevron Phillips Chemical Company LP

发明人： Lei Ji ,  Ai-Fu Chang

IPC分类号： C08F2/00 ,  C08F210/00 ,  B01D53/04 ,  C07C7/13 ,  C08F110/02 ,  B01J19/00 ,  C07C7/12 ,  B01J8/08

CPC分类号： B01D53/0462 ,  B01D53/0407 ,  B01D2253/102 ,  B01D2253/108 ,  B01D2253/116 ,  B01D2253/204 ,  B01D2256/24 ,  B01D2257/7022 ,  B01D2259/40043 ,  B01J8/085 ,  B01J8/087 ,  B01J19/00 ,  B01J2208/00212 ,  B01J2208/00274 ,  B01J2219/0004 ,  B01J2219/00837 ,  B01J2219/00842 ,  C07C7/12 ,  C07C7/13 ,  C08F110/02 ,  Y02P20/582 ,  C08F10/02 ,  C08F2/01 ,  C08F210/16 ,  C08F210/14 ,  C08F2/14 ,  C07C11/04

摘要： A process for component separation in a polymer production system, comprising (a) separating a polymerization product stream into a gas stream and a polymer stream, (b) contacting the polymer stream with a purge gas to yield a purged polymer and a spent purge gas comprising purge gas, ethylene, and ethane, (c) contacting the spent purge gas with a temperature swing adsorber contactor (TSAC) to yield a loaded TSAC, wherein at least a portion of the ethylene is adsorbed by the TSAC at a first temperature to yield TSAC-adsorbed ethylene, wherein a portion of the ethane is adsorbed by the TSAC at the first temperature to yield TSAC-adsorbed ethane, (d) heating the loaded TSAC to a second temperature to yield a regenerated TSAC, and (e) contacting the regenerated TSAC with a sweeping gas stream to yield a recovered adsorbed gas stream comprising sweeping gas, recovered ethylene and recovered ethane.

公开(公告)号：US20150335769A1

公开(公告)日：2015-11-26

申请号：US14235005

申请日：2012-12-26

申请人： Hitachi, Ltd.

发明人： Nami SUGITA ,  Naomi MANRI ,  Wataru TAKEUCHI ,  Yuichi MORIMOTO ,  Hiroko HANZAWA

IPC分类号： A61K51/08 ,  B01J19/24 ,  B01J19/00

CPC分类号： A61K51/088 ,  B01F13/0062 ,  B01F13/0066 ,  B01J19/0006 ,  B01J19/0093 ,  B01J19/24 ,  B01J2219/00049 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00842 ,  B01J2219/00873 ,  B01J2219/0088 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2219/24 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  C07B59/00 ,  Y10T436/12

摘要： A reaction container in which to mix a first chemical compound with a second chemical compound has a main body and a lid member formed oppositely on a top face side of the main body; a flow channel on the top face of the main body; and a labeling agent solidification section at an intermediate section of the flow channel to remove a solvent in a solution of the second chemical compound and solidify the second chemical compound. First and second chemical compound supply sections and a mixture discharge section are formed on the upstream and downstream sides of the labeling agent solidification section, respectively. The reactor is provided with a liquid sending unit to supply the first and second chemical compounds and reciprocally send a solution of the first chemical compound to an upper part of the second chemical compound solidified at the solidification section.

摘要翻译： 将第一化合物与第二化合物混合的反应容器具有主体和在主体的顶面相对地形成的盖部件; 主体顶面上的流路; 以及在流路的中间部分处的标记剂固化部分，以除去第二化合物的溶液中的溶剂并固化第二化合物。 分别在标签试剂凝固部的上游侧和下游侧形成第一和第二化合物供给部和混合物排出部。 反应器设有一个送液单元，用于供应第一和第二化合物，并将第一化合物的溶液往凝固段固化的第二化合物的上部相互转移。