公开(公告)号：US20180326390A1

公开(公告)日：2018-11-15

申请号：US15774756

申请日：2016-11-14

申请人： PTT PUBLIC COMPANY LIMITED

发明人： Goran Nadezda Jovanovic ,  Frederick Atadana

IPC分类号： B01J19/00 ,  B01F13/00 ,  B01F3/04 ,  B01F5/04 ,  B01J23/883

CPC分类号： B01J19/0093 ,  B01F3/04503 ,  B01F5/0428 ,  B01F13/0059 ,  B01J23/883 ,  B01J2219/00783 ,  B01J2219/00808 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/00855 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00963 ,  B01J2219/00986 ,  C10G3/00 ,  Y02E50/13 ,  Y02P30/20

摘要： Disclosed microscale reactors comprise lamina for carrying out multi-phase reactions for making desired chemical products, such as biohydrogenated diesel (BHD). Microreactor embodiments include a bottom clamp plate, a top clamp plate, and at least one catalyst plate positioned between and operatively associated with the bottom clamp plate and the top clamp plate. Catalyst plates include a catalyst associated for catalyzing the production of product from feedstock. To address the problems encountered when using microchannel reactors, the microscale-based reactors may include a mixer plate assembly and/or at least one catalyst lamina comprising an array of microscale posts. Disclosed microreactor systems for producing BHD include a feedstock source, a hydrogen source and an inert gas source each fluidly coupled to respective microreactor inlets. Certain method embodiments include operating a microreactor or a microreactor system to produce BHD from a suitable feedstock selected from animal fats, vegetable oils, or combinations thereof.

公开(公告)号：US10076751B2

公开(公告)日：2018-09-18

申请号：US14144047

申请日：2013-12-30

申请人： General Electric Company

发明人： Victor Donald Samper ,  Christian Friedrich Peter Rensch ,  Christoph Boeld ,  Ruben Julian Salvamoser

IPC分类号： B01L3/00 ,  B01J19/00 ,  F16K99/00

CPC分类号： B01L3/502715 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00966 ,  B01J2219/00986 ,  B01L3/523 ,  B01L2200/028 ,  B01L2200/04 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0887 ,  B01L2300/16 ,  B01L2400/0638 ,  B01L2400/0683 ,  F16K99/0015 ,  F16K99/003 ,  F16K2099/0084 ,  Y10T156/10

摘要： A microfluidic device for storing a reagent includes a single unit includes a first portion having a reagent storage chamber configured to hold a reagent. The device also includes a second portion having a reaction chamber configured to support the reagent during a reaction process to form a product. The device also includes a valve configured to isolate the reagent storage compartment from the reaction chamber when the valve is in a closed state.

公开(公告)号：US20170181979A1

公开(公告)日：2017-06-29

申请号：US15300492

申请日：2015-03-25

申请人： SHIMADZU CORPORATION

发明人： Takashi KAWABE ,  Eiichi OZEKI

IPC分类号： A61K9/51 ,  A61K51/12 ,  C08G69/44 ,  A61K49/12 ,  A61K51/06 ,  C08J3/12 ,  B01J19/00 ,  A61K49/18

CPC分类号： A61K9/5192 ,  A61K9/5153 ,  A61K49/126 ,  A61K49/1824 ,  A61K51/06 ,  A61K51/1262 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00903 ,  B01J2219/00954 ,  B01J2219/00961 ,  B01J2219/0097 ,  B01J2219/00986 ,  B82Y5/00 ,  B82Y40/00 ,  C08G69/44 ,  C08J3/07 ,  C08J3/12 ,  C08J2353/00 ,  C08J2377/12

摘要： Provided is a method for producing a nanoparticle having a uniform particle diameter. A method for producing a nanoparticle comprising an amphiphilic block polymer, the method comprising: with use of a nanoparticle production device that includes: a polymer solution supply channel Cp; an aqueous liquid supply channel Cw1, Cw2; a junction J of the channels; a nanoparticle formation channel Cn; and a nanoparticle-containing liquid outlet On, supplying a solution of a polymer and an aqueous liquid to the junction J; forming a nanoparticle while bringing a laminar flow of the polymer solution and a laminar flow of the aqueous liquid into contact with each other; obtaining a liquid containing the formed nanoparticle from the nanoparticle-containing liquid outlet; and controlling a particle diameter of the nanoparticle by measuring a statistic of the particle diameter of the formed nanoparticle in real time, and by controlling at least one of an amount of the polymer solution supplied to the junction and an amount of the aqueous liquid supplied to the junction such that the statistic becomes a desired value.

公开(公告)号：US09636655B2

公开(公告)日：2017-05-02

申请号：US13314170

申请日：2011-12-07

申请人： Lester F. Ludwig

发明人： Lester F. Ludwig

IPC分类号： B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  G01N35/00

CPC分类号： B01J19/0093 ,  B01J2219/00835 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00905 ,  B01J2219/00986 ,  B01J2219/00997 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L9/52 ,  B01L2200/10 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2400/0421 ,  B01L2400/0487 ,  B01L2400/0622 ,  B01L2400/0644 ,  B01L2400/086 ,  G01N35/0092 ,  Y10T436/12

摘要： Systems and methods for software-reconfigurable chemical process systems useful in a wide range of applications. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal. In other embodiments, a flexible software-reconfigurable multipurpose reusable laboratory glassware setup may be realized, sparing talented laboratory staff from repetitive, complex, or low-level tasks occurring in analysis, synthesis, or smallscale chemical manufacturing.

公开(公告)号：US09421284B2

公开(公告)日：2016-08-23

申请号：US14235005

申请日：2012-12-26

申请人： Hitachi, Ltd.

发明人： Nami Sugita ,  Naomi Manri ,  Wataru Takeuchi ,  Yuichi Morimoto ,  Hiroko Hanzawa

IPC分类号： B01J19/24 ,  A61K51/08 ,  B01J19/00 ,  B01L3/00 ,  B01F13/00 ,  C07B59/00

CPC分类号： A61K51/088 ,  B01F13/0062 ,  B01F13/0066 ,  B01J19/0006 ,  B01J19/0093 ,  B01J19/24 ,  B01J2219/00049 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00842 ,  B01J2219/00873 ,  B01J2219/0088 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2219/24 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  C07B59/00 ,  Y10T436/12

摘要： A reaction container in which to mix a first chemical compound with a second chemical compound has a main body and a lid member formed oppositely on a top face side of the main body; a flow channel on the top face of the main body; and a labeling agent solidification section at an intermediate section of the flow channel to remove a solvent in a solution of the second chemical compound and solidify the second chemical compound. First and second chemical compound supply sections and a mixture discharge section are formed on the upstream and downstream sides of the labeling agent solidification section, respectively. The reactor is provided with a liquid sending unit to supply the first and second chemical compounds and reciprocally send a solution of the first chemical compound to an upper part of the second chemical compound solidified at the solidification section.

摘要翻译： 将第一化合物与第二化合物混合的反应容器具有主体和在主体的顶面相对地形成的盖部件; 主体顶面上的流路; 以及在流路的中间部分处的标记剂固化部分，以除去第二化合物的溶液中的溶剂并固化第二化合物。 分别在标签试剂凝固部的上游侧和下游侧形成第一和第二化合物供给部和混合物排出部。 反应器设有一个送液单元，用于供应第一和第二化合物，并将第一化合物的溶液往凝固段固化的第二化合物的上部相互转移。

公开(公告)号：US09254486B2

公开(公告)日：2016-02-09

申请号：US14619791

申请日：2015-02-11

申请人： InCube Labs, LLC

发明人： Mir A. Imran

IPC分类号： F04F5/48 ,  B01L3/00 ,  B01J19/00 ,  F04B19/00

CPC分类号： B01L3/50273 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00961 ,  B01J2219/00966 ,  B01J2219/00981 ,  B01J2219/00986 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/022 ,  B01L2300/023 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/18 ,  B01L2300/1827 ,  B01L2300/1866 ,  B01L2400/0442 ,  B01L2400/049 ,  B01L2400/06 ,  B01L2400/0605 ,  F04B19/006 ,  Y10T137/2877 ,  Y10T137/7559 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86075

摘要： Embodiments described herein provide micro-fluidic systems and devices for use in performing various diagnostic and analytical tests. According to one embodiment, the micro-fluidic device includes a sample chamber for receiving a sample, and a reaction chamber for performing a chemical reaction. A bubble jet pump is structured on the device to control delivery of a fluid from the sample chamber to the reaction chamber. The pump is fluidically coupled to one or more chambers of the device using a fluidic channel such as a capillary. A valve may be coupled to one or more chambers to control flow into and out of those chambers. Also, a sensor may be positioned in one or more of the chambers, such as the reactant chamber, for sensing a property of the fluid within the chamber as well as the presence of a chemical within the chamber.

公开(公告)号：US20150335769A1

公开(公告)日：2015-11-26

申请号：US14235005

申请日：2012-12-26

申请人： Hitachi, Ltd.

发明人： Nami SUGITA ,  Naomi MANRI ,  Wataru TAKEUCHI ,  Yuichi MORIMOTO ,  Hiroko HANZAWA

IPC分类号： A61K51/08 ,  B01J19/24 ,  B01J19/00

CPC分类号： A61K51/088 ,  B01F13/0062 ,  B01F13/0066 ,  B01J19/0006 ,  B01J19/0093 ,  B01J19/24 ,  B01J2219/00049 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/00842 ,  B01J2219/00873 ,  B01J2219/0088 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00905 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  B01J2219/24 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  C07B59/00 ,  Y10T436/12

摘要： A reaction container in which to mix a first chemical compound with a second chemical compound has a main body and a lid member formed oppositely on a top face side of the main body; a flow channel on the top face of the main body; and a labeling agent solidification section at an intermediate section of the flow channel to remove a solvent in a solution of the second chemical compound and solidify the second chemical compound. First and second chemical compound supply sections and a mixture discharge section are formed on the upstream and downstream sides of the labeling agent solidification section, respectively. The reactor is provided with a liquid sending unit to supply the first and second chemical compounds and reciprocally send a solution of the first chemical compound to an upper part of the second chemical compound solidified at the solidification section.

摘要翻译： 将第一化合物与第二化合物混合的反应容器具有主体和在主体的顶面相对地形成的盖部件; 主体顶面上的流路; 以及在流路的中间部分处的标记剂固化部分，以除去第二化合物的溶液中的溶剂并固化第二化合物。 分别在标签试剂凝固部的上游侧和下游侧形成第一和第二化合物供给部和混合物排出部。 反应器设有一个送液单元，用于供应第一和第二化合物，并将第一化合物的溶液往凝固段固化的第二化合物的上部相互转移。

公开(公告)号：US08658112B2

公开(公告)日：2014-02-25

申请号：US13286418

申请日：2011-11-01

申请人： Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

发明人： Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

IPC分类号： G01N33/00

CPC分类号： B01F11/0042 ,  B01F11/0071 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00858 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00916 ,  B01J2219/00927 ,  B01J2219/00986

摘要： Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.

摘要翻译： 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。

公开(公告)号：US08425748B2

公开(公告)日：2013-04-23

申请号：US13572377

申请日：2012-08-10

申请人： Seth Adrian Miller

发明人： Seth Adrian Miller

IPC分类号： G01N27/26 ,  C02F1/40 ,  B01F3/00 ,  B01F3/08

CPC分类号： F04B19/006 ,  B01F3/0807 ,  B01F13/0076 ,  B01J19/0093 ,  B01J2219/00047 ,  B01J2219/00853 ,  B01J2219/00889 ,  B01J2219/00986

摘要： Techniques are generally described that include electrokinetic pumping an emulsion comprising an ionic fluid and a nonpolar fluid to promote flow of the ionic fluid by electro-osmotic flow and drag the nonpolar fluid by viscous drag forces. In some examples, the electrokinetic pump may be utilized to deliver one or more reagents within a fluidic reactor system, such as a micro-scale reactor system. In some additional examples, a reagent may be dissolved in the nonpolar fluid of a first emulsion and pumped through the electrokinetic pump to a mixing channel to allow the reagent of the first emulsion to react with a reagent of second emulsion to form a reactive product.

摘要翻译： 通常描述的技术包括电动泵送包含离子流体和非极性流体的乳液以促进离子流体通过电渗流的流动，并通过粘性阻力拖动非极性流体。 在一些实例中，电动泵可以用于在流体反应器系统（例如微量级反应器系统）内递送一种或多种试剂。 在一些另外的实施例中，试剂可以溶解在第一乳液的非极性流体中，并通过电动泵泵送到混合通道，以允许第一乳液的试剂与第二乳液的试剂反应形成反应产物。

公开(公告)号：US20120201725A1

公开(公告)日：2012-08-09

申请号：US13448235

申请日：2012-04-16

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： B01L3/00

CPC分类号： B01L3/50273 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00961 ,  B01J2219/00966 ,  B01J2219/00981 ,  B01J2219/00986 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/022 ,  B01L2300/023 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/18 ,  B01L2300/1827 ,  B01L2300/1866 ,  B01L2400/0442 ,  B01L2400/049 ,  B01L2400/06 ,  B01L2400/0605 ,  F04B19/006 ,  Y10T137/2877 ,  Y10T137/7559 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86075

摘要： Embodiments described herein provide micro-fluidic systems and devices for use in performing various diagnostic and analytical tests. According to one embodiment, the micro-fluidic device includes a sample chamber for receiving a sample, and a reaction chamber for performing a chemical reaction. A bubble jet pump is structured on the device to control delivery of a fluid from the sample chamber to the reaction chamber. The pump is fluidically coupled to one or more chambers of the device using a fluidic channel such as a capillary. A valve may be coupled to one or more chambers to control flow into and out of those chambers. Also, a sensor may be positioned in one or more of the chambers, such as the reactant chamber, for sensing a property of the fluid within the chamber as well as the presence of a chemical within the chamber.

摘要翻译： 本文所述的实施例提供用于执行各种诊断和分析测试的微流体系统和装置。 根据一个实施例，微流体装置包括用于接收样品的样品室和用于进行化学反应的反应室。 气泡喷射泵被构造在装置上以控制流体从样品室传送到反应室。 泵使用诸如毛细管的流体通道流体地耦合到装置的一个或多个室。 阀可以联接到一个或多个室以控制流入和流出这些室。 此外，传感器可以定位在一个或多个室中，例如反应物室，用于感测室内的流体的性质以及室内的化学物质的存在。