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公开(公告)号：US20190176122A1
公开(公告)日：2019-06-13
申请号：US16094091
申请日：2017-04-24
Applicant: Purdue Research Foundation
Inventor： Andy Koswara , Zoltan Kalman Nagy , Conor Douglas Parks
IPC: B01J19/00 , C07D207/16 , C07C213/06
CPC classification number: B01J19/0093 , B01J2219/00783 , B01J2219/00792 , B01J2219/0081 , B01J2219/00813 , B01J2219/00867 , B01J2219/00873 , B01J2219/0088 , B01J2219/00891 , B01J2219/00905 , B01J2219/00909 , B01J2219/00916 , B01J2219/00954 , B01J2219/00959 , B01J2219/00968 , B01J2219/0097 , B01J2219/00986 , B01J2219/00995 , B01J2219/00997 , C07C213/06 , C07D207/16
Abstract: The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.
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2.发明申请公开(公告)号：US20180016296A1
公开(公告)日：2018-01-18
申请号：US15545924
申请日：2016-02-03
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Jennifer Marie Murphy , Mark Saul Lazari
CPC classification number: C07J31/006 , B01J19/004 , B01J19/0093 , B01J2219/00011 , B01J2219/00799 , B01J2219/00813 , B01J2219/00817 , B01J2219/00831 , B01J2219/0084 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/00916 , B01J2219/00927 , B01J2219/00936 , B01J2219/00957 , B01J2219/00986 , C07J1/0022 , C07J21/006 , C07J75/00
Abstract: The automated synthesis of clinically relevant amounts of 16β-18F-fluoro-5α-dihydrotestosterone (18F-FDHT) using a commercially available radiosynthesizer. Synthesis was performed in 90 minutes with a decay-corrected radiochemical yield of 29±5%. The specific activity was 4.6 Ci/μmol (170 GBq/μmol) at end of formulation with a starting activity of 1.0 Ci (37 GBq). The formulated 18F-FDHT yielded sufficient activity for multiple patient doses and passed all quality control tests required for routine clinical use.
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公开(公告)号：US09556081B2
公开(公告)日：2017-01-31
申请号：US14990567
申请日：2016-01-07
Applicant: ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH , GESIM-GESELLSCHAFT FUER SILIZIUM-MIKROSYSTEME MBH
Inventor： Marco Mueller , Steffen Howitz
CPC classification number: C07B59/005 , B01J19/004 , B01J19/0046 , B01J19/0093 , B01J2219/00038 , B01J2219/0004 , B01J2219/00094 , B01J2219/00132 , B01J2219/00141 , B01J2219/00283 , B01J2219/00333 , B01J2219/00364 , B01J2219/00585 , B01J2219/00599 , B01J2219/00704 , B01J2219/0072 , B01J2219/00731 , B01J2219/00788 , B01J2219/0081 , B01J2219/00882 , B01J2219/00889 , B01J2219/00916 , B01J2219/00941 , C07B59/00 , C07B2200/05 , C07H5/02
Abstract: The invention relates to a method for the preparation of radiochemical compounds using a device having at least a reaction module, a dosing module, and a storage module, wherein the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module. Substances needed for the preparation of the respective radiochemical compound are introduced into the reaction vessel of the reaction module by means of dosing units, wherein the dosing units can be moved via a pipetting head in x, y directions or in x, y, and z directions.
Abstract translation: 本发明涉及使用至少具有反应模块，剂量模块和储存模块的装置来制备放射化学化合物的方法，其中反应模块具有至少一个具有可闭合的开口的反应容器， 可以将预定的放射化学化合物的制备物引入反应模块的反应容器中，通过该反应装置可以从反应模块的反应容器中除去所制备的放射化学化合物; 所述计量模块具有至少一个移液头，其可相对于所述储存模块和所述反应模块以及x，y和z方向移动，并且还具有至少一个计量单元; 并且在储存模块中形成用于制备各放射化学化合物所需的物质之一的至少一个贮存器。 制备相应的放射化学化合物所需的物质通过计量单元被引入反应模块的反应容器中，其中计量单元可以通过移液头沿x，y方向或x，y和z移动 方向。
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公开(公告)号：US09260354B2
公开(公告)日：2016-02-16
申请号：US14592283
申请日：2015-01-08
Applicant: ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH , GESIM-GESELLSCHAFT FUER SILIZIUM-MIKROSYSTEME MBH
Inventor： Marco Mueller , Steffen Howitz
CPC classification number: C07B59/005 , B01J19/004 , B01J19/0046 , B01J19/0093 , B01J2219/00038 , B01J2219/0004 , B01J2219/00094 , B01J2219/00132 , B01J2219/00141 , B01J2219/00283 , B01J2219/00333 , B01J2219/00364 , B01J2219/00585 , B01J2219/00599 , B01J2219/00704 , B01J2219/0072 , B01J2219/00731 , B01J2219/00788 , B01J2219/0081 , B01J2219/00882 , B01J2219/00889 , B01J2219/00916 , B01J2219/00941 , C07B59/00 , C07B2200/05 , C07H5/02
Abstract: The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module; the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; and at least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module.
Abstract translation: 本发明涉及一种用于制备放射化学化合物的装置。 该装置至少包括反应模块，计量模块和存储模块，其中反应模块具有至少一个反应容器，该反应容器具有可闭合的开口，制备预定的放射化学化合物所需的物质可以通过该封闭开口 引入反应模块的反应容器中，通过该反应模块可以从反应模块的反应容器中除去所制备的放射化学化合物; 所述计量模块具有至少一个移液头，其可相对于所述储存模块和所述反应模块以及x，y和z方向移动，并且还具有至少一个计量单元; 并且在储存模块中形成用于制备各放射化学化合物所需的物质之一的至少一个贮存器。
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5.发明授权Automatic system for synthesizing 123I-MIBG and automatic device for synthesizing and dispensing 123I-MIBG comprising the same 有权用于合成123I-MIBG的自动系统和用于合成和分配123I-MIBG的自动装置公开(公告)号：US09221029B2
公开(公告)日：2015-12-29
申请号：US14464461
申请日：2014-08-20
Inventor： Tsai-Yueh Luo , Te-Sheng Liang , Ying-Hsia Shih , Wuu-Jyh Lin
CPC classification number: B01J19/0006 , A61K51/04 , A61K51/0406 , B01J19/00 , B01J19/0013 , B01J19/0093 , B01J19/24 , B01J2219/00051 , B01J2219/00182 , B01J2219/00799 , B01J2219/00862 , B01J2219/00869 , B01J2219/00873 , B01J2219/00894 , B01J2219/00916 , B01J2219/00961 , B01J2219/00986 , B01J2219/0099 , C07B59/00
Abstract: The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine (123I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidine (MIBG) sulfate to an iodine-iodine exchange reaction to obtain radioactive iodine labeled MIBG; a purification unit for purifying the iodine labeled MIBG; and a second reactor for substituting a solvent used in purification with a phosphate buffer to obtain a phosphate solution containing 123I-MIBG. The present invention also relates to an automatic device for dispensing 123I-MIBG, which comprises the automatic system for synthesizing 123I-MIBG, a radioactivity measuring unit, and a dispensing and packing unit.
Abstract translation: 本发明涉及一种用于合成碘-123间碘碘苄基胍（123I-MIBG）的自动化系统，其包括用于使放射性碘碘化钠和间碘碘苄基胍（MIBG）硫酸盐进行碘 - 碘交换反应的第一反应器 获得放射性碘标记的MIBG; 用于纯化碘标记的MIBG的纯化单元; 和用磷酸盐缓冲液代替纯化用溶剂的第二反应器，得到含有123I-MIBG的磷酸盐溶液。 本发明还涉及用于分配123I-MIBG的自动装置，其包括用于合成123I-MIBG的自动系统，放射性测量单元和分配和包装单元。
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Patent Agency Ranking
6.发明申请Microfluidic Chip Capable of Synthesizing Radioactively Labeled Molecules on a Scale Suitable for Human Imaging With Positron Emission Tomography 有权具有合适放射性标记分子的微流控芯片，适用于具有正电子发射断层扫描的人体成像公开(公告)号：US20120101268A1
公开(公告)日：2012-04-26
申请号：US13286418
申请日：2011-11-01
Applicant: Arkadij M. Elizarov , Hartmuth C. Kolb , R. Michael Van Dam , James R. Heath
Inventor： Arkadij M. Elizarov , Hartmuth C. Kolb , R. Michael Van Dam , James R. Heath
CPC classification number: B01F11/0042 , B01F11/0071 , B01F13/0059 , B01J19/0093 , B01J2219/00286 , B01J2219/00396 , B01J2219/00398 , B01J2219/00414 , B01J2219/00418 , B01J2219/00495 , B01J2219/00585 , B01J2219/00599 , B01J2219/00731 , B01J2219/00759 , B01J2219/00783 , B01J2219/00788 , B01J2219/00822 , B01J2219/00824 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00858 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00907 , B01J2219/00916 , B01J2219/00927 , B01J2219/00986
Abstract: Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.
Abstract translation: 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。
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公开(公告)号：US07005301B2
公开(公告)日：2006-02-28
申请号：US10456772
申请日：2003-06-06
Applicant: Eric B. Cummings , Gregory J. Fiechtner
Inventor： Eric B. Cummings , Gregory J. Fiechtner
IPC: B01L3/02
CPC classification number: G01N30/6086 , B01F5/0646 , B01F5/0648 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00891 , B01J2219/00916 , B01J2219/00995 , B01J2219/00997 , B01L3/502746 , B01L2300/0861 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B01L2400/086 , G01N27/44756 , G01N2030/285 , Y10T436/2575
Abstract: A low-dispersion methodology for designing microfabricated conduction channels for on-chip electrokinetic-based systems is presented. The technique relies on trigonometric relations that apply for ideal electrokinetic flows, allowing faceted channels to be designed on chips using common drafting software and a hand calculator. Flows are rotated and stretched along the abrupt interface between adjacent regions with differing permeability. Regions bounded by interfaces form flow “prisms” that can be combined with other designed prisms to obtain a wide range of turning angles and expansion ratios while minimizing dispersion. Designs are demonstrated using two-dimensional numerical solutions of the Laplace equation.
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公开(公告)号：US06919046B2
公开(公告)日：2005-07-19
申请号：US10164887
申请日：2002-06-07
Applicant: Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Courtney Coyne , Steven E. Hobbs , Eugene Dantsker
Inventor： Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Courtney Coyne , Steven E. Hobbs , Eugene Dantsker
CPC classification number: B01F5/0682 , B01F5/0688 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00822 , B01J2219/00833 , B01J2219/00837 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00909 , B01J2219/00916 , B01J2219/00934 , B01J2219/00961 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/18 , B01L2400/0487 , B01L2400/0638 , B01L2400/084 , B82Y30/00 , G01N21/05 , G01N2021/0346 , G01N2021/056 , G01N2021/058 , Y10T137/0491 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
Abstract: Modular microfluidic systems includes a plurality of microfluidic modules, each capable of performing fluidic operations including, but not limited to, filtering, splitting, regulating pressure, mixing, metering, reacting, diverting, heating, cooling, and condensing are provided. The microfluidic modules are polymeric, stencil-based structures adapted to be coupled in sequence for performing biological or chemical synthesis, including, but not limited to, chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products.
Abstract translation: 模块化微流体系统包括多个微流体模块，其各自能够执行流体操作，包括但不限于过滤，分离，调节压力，混合，计量，反应，转向，加热，冷却和冷凝。 微流体模块是适合于依次耦合以进行生物或化学合成的聚合物，基于蜡纸的结构，包括但不限于有机，聚合物，无机，寡核苷酸，肽，蛋白质，细菌和 酶产品。
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9.发明申请Process for producing mass transfer device and apparatus for production thereof 失效用于生产传质装置的方法及其制造装置公开(公告)号：US20050121378A1
公开(公告)日：2005-06-09
申请号：US11030289
申请日：2005-01-07
Applicant: Takeo Yamazaki , Naoto Mihashi , Takeshi Imamura , Satoko Omizu
Inventor： Takeo Yamazaki , Naoto Mihashi , Takeshi Imamura , Satoko Omizu
IPC: B01D15/20 , B01J19/00 , B01J20/281 , B01J20/283 , B01J20/287 , B01J23/72 , B01J35/04 , B01L3/00 , G01N30/46 , G01N30/56 , G01N30/60 , G01N30/88 , B01D15/08
CPC classification number: G01N30/466 , B01D15/206 , B01J19/0093 , B01J20/283 , B01J20/287 , B01J23/72 , B01J35/04 , B01J2219/00783 , B01J2219/00835 , B01J2219/00916 , B01L3/5027 , B01L3/502707 , B01L3/502753 , B01L2200/12 , G01N30/56 , G01N30/6043 , G01N30/6086 , G01N30/6095 , G01N2030/565
Abstract: A process for producing a mass transfer device is provided which enables packing of a packing material uniformly in a flow channel, and transfers a specified substance by flowing a fluid containing the specified substance through a flow channel on a substrate. A mass transfer device produced by the process is also provided. The process for producing a mass transfer device comprises steps of preparing a substrate, forming a flow channel on the surface of the substrate, applying a liquid drop composed of a packing material and a liquid medium, and packing the packing material in the flow channel by removing the liquid medium.
Abstract translation: 提供一种生产传质装置的方法，其能够将包装材料均匀地包封在流动通道中，并且通过使含有特定物质的流体通过基板上的流动通道流动来转移特定物质。 还提供了通过该方法生产的传质装置。 制造传质装置的方法包括以下步骤：制备基材，在基材的表面上形成流动通道，施加由包装材料和液体介质组成的液滴，并将包装材料包装在流动通道中 去除液体介质。
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公开(公告)号：US20030139630A1
公开(公告)日：2003-07-24
申请号：US10296459
申请日：2002-11-25
Inventor： Hanns Wurziger , Guido Pieper , Norbert Schwesinger
IPC: C07C029/15 , C07C027/22
CPC classification number: C07B41/06 , B01J19/0093 , B01J2219/0086 , B01J2219/00862 , B01J2219/00873 , B01J2219/00889 , B01J2219/00916 , C07C45/00 , C07D209/12
Abstract: The present invention relates to a process for the formylation of organic compounds.
Abstract translation: 本发明涉及有机化合物甲酰化的方法
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