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公开(公告)号：US20050284213A1
公开(公告)日：2005-12-29
申请号：US10880656
申请日：2004-06-29
Applicant: Christoph Karp , Marci Pezzuto , Steven Hobbs
Inventor： Christoph Karp , Marci Pezzuto , Steven Hobbs
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/565 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2400/0487 , G01N30/6026 , G01N30/6095
Abstract: A threadless interface for a fluidic system includes a microfluidic device having an outer surface and an internal near-surface channel having a first width and disposed at a first depth relative to the outer surface, with the first width being less than about two times the first depth. A fluidic seal engages the outer surface and exerts an elevated contact pressure against at least a portion of the outer surface without substantially occluding the channel. A preferred seal includes a raised boss. A fault tolerant flow path design can accommodate misalignment between adjacent device layers without detrimentally affecting fluid flow capability. The interface may be used in a microfluidic system for performing parallel analyses such as high performance liquid chromatography.
Abstract translation: 用于流体系统的无螺纹接口包括具有外表面和内部近表面通道的微流体装置，其具有第一宽度并且相对于外表面设置在第一深度，第一宽度小于第一宽度的大约两倍 深度。 流体密封件接合外表面并且相对于外表面的至少一部分施加升高的接触压力，而基本上不堵塞通道。 优选的密封件包括凸起的凸起。 容错流路设计可以适应相邻设备层之间的不对准，而不会有不利地影响流体流动能力。 该界面可用于微流体系统中以进行并行分析，例如高效液相色谱法。
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公开(公告)号：US06919046B2
公开(公告)日：2005-07-19
申请号：US10164887
申请日：2002-06-07
Applicant: Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Courtney Coyne , Steven E. Hobbs , Eugene Dantsker
Inventor： Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Courtney Coyne , Steven E. Hobbs , Eugene Dantsker
CPC classification number: B01F5/0682 , B01F5/0688 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00822 , B01J2219/00833 , B01J2219/00837 , B01J2219/00867 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00909 , B01J2219/00916 , B01J2219/00934 , B01J2219/00961 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/18 , B01L2400/0487 , B01L2400/0638 , B01L2400/084 , B82Y30/00 , G01N21/05 , G01N2021/0346 , G01N2021/056 , G01N2021/058 , Y10T137/0491 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
Abstract: Modular microfluidic systems includes a plurality of microfluidic modules, each capable of performing fluidic operations including, but not limited to, filtering, splitting, regulating pressure, mixing, metering, reacting, diverting, heating, cooling, and condensing are provided. The microfluidic modules are polymeric, stencil-based structures adapted to be coupled in sequence for performing biological or chemical synthesis, including, but not limited to, chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products.
Abstract translation: 模块化微流体系统包括多个微流体模块，其各自能够执行流体操作，包括但不限于过滤，分离，调节压力，混合，计量，反应，转向，加热，冷却和冷凝。 微流体模块是适合于依次耦合以进行生物或化学合成的聚合物，基于蜡纸的结构，包括但不限于有机，聚合物，无机，寡核苷酸，肽，蛋白质，细菌和 酶产品。
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公开(公告)号：US06729352B2
公开(公告)日：2004-05-04
申请号：US10165448
申请日：2002-06-07
Applicant: Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Paren P. Patel , Steven E. Hobbs , Eugene Dantsker
Inventor： Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Paren P. Patel , Steven E. Hobbs , Eugene Dantsker
IPC: F15C114
CPC classification number: B01F5/0471 , B01F5/064 , B01F13/0059 , B01F15/0205 , B01F15/0264 , B01J19/0093 , B01J2219/00783 , B01J2219/00889 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/06 , B01L2400/0688 , B82Y30/00 , Y10T137/2164 , Y10T137/2191 , Y10T137/2224 , Y10T137/85938
Abstract: A microfluidic reactor for performing chemical and biological synthesis reactions, including chemical and biological syntheses of organic, polymer, inorganic, oligonucleotide, peptide, protein, bacteria, and enzymatic products is provided. Two fluids are input into the device, mixed in a mixing region and provided to a long, composite reaction channel. Fluids flowing through the reaction channel may be diverted at a diversion region into a sample channel. Fluids in the sample channel may be mixed at a second region, with additional reagents.
Abstract translation: 提供了用于进行化学和生物合成反应的微流体反应器，包括有机，聚合物，无机，寡核苷酸，肽，蛋白质，细菌和酶产物的化学和生物合成。 将两种流体输入到装置中，在混合区域中混合并提供给长的复合反应通道。 流过反应通道的流体可以在分流区域被转移到样品通道中。 样品通道中的液体可以在第二区域与另外的试剂混合。
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4.发明授权公开(公告)号：US07318912B2
公开(公告)日：2008-01-15
申请号：US10150427
申请日：2002-05-16
Applicant: Marci Pezzuto , Eugene Dantsker
Inventor： Marci Pezzuto , Eugene Dantsker
CPC classification number: B01F5/0471 , B01F5/064 , B01F13/0059 , B01F15/0205 , B01F15/0264 , B01L3/502707 , B01L3/502738 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/06 , B01L2400/0683 , B01L2400/0688 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T137/0318 , Y10T137/2496 , Y10T137/2501 , Y10T137/2562 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
Abstract: Microfluidic devices capable of combining discrete fluid volumes generally include channels for supplying different fluids toward a sample chamber and means for establishing fluid communication between the fluids within the chamber. Discrete fluid plugs are defined from larger fluid volumes before being combined. Certain embodiments utilize adjacent chambers or subchambers divided by a rupture region such as a frangible seal. Further embodiments utilize one or more deformable membranes and/or porous regions to direct fluid flow. Certain devices may be pneumatically or magnetically actuated.
Abstract translation: 能够组合离散流体体积的微流体装置通常包括用于向样品室供应不同流体的通道和用于在室内的流体之间建立流体连通的装置。 离散流体塞在组合之前由更大的流体体积定义。 某些实施例利用由诸如易碎密封件之类的破裂区域分开的相邻室或子室。 另外的实施例利用一个或多个可变形膜和/或多孔区域来引导流体流动。 某些装置可以是气动或磁力驱动的。
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公开(公告)号：US06755211B1
公开(公告)日：2004-06-29
申请号：US10405109
申请日：2003-03-31
Applicant: Stephen D. O'Connor , Eugene Dantsker , Marci Pezzuto
Inventor： Stephen D. O'Connor , Eugene Dantsker , Marci Pezzuto
IPC: F15C100
CPC classification number: B01L3/502738 , B01L3/502746 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/0688 , F15C1/02 , F15D1/02 , F16K99/0001 , F16K99/0017 , F16K99/0028 , F16K99/0049 , F16K99/0055 , F16K99/0057 , F16K2099/008 , Y10T137/0491 , Y10T137/2191 , Y10T137/2224 , Y10T137/598 , Y10T137/8242 , Y10T137/86035
Abstract: Microfluidic systems and devices having integrated fluidic impedances are provided. Such impedances hinder the passage of fluid at low differential pressures, but allow fluid flow at higher differential pressures. Impedances are formed at the overlap of two or more microfluidic channels contained in different layers of a device. Such devices can be rapidly prototyped and can be assembled to contain multiple fluidic impedances to perform complex fluid handling tasks, including the metering of small aliquots from a larger fluid volume. Various means may be used to overcome the fluidic impedances.
Abstract translation: 提供具有集成的流体阻抗的微流体系统和装置。 这种阻抗阻碍了流体在低压差下通过，但允许流体在较高压差下流动。 在包含在器件的不同层中的两个或更多个微流体通道的重叠处形成阻抗。 这样的装置可以快速原型化并且可以被组装以包含多个流体阻抗以执行复杂的流体处理任务，包括从更大的流体体积计量小等分试样。 可以使用各种手段来克服流体阻抗。
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Patent Agency Ranking
公开(公告)号：US06561208B1
公开(公告)日：2003-05-13
申请号：US09550184
申请日：2000-04-14
Applicant: Stephen D. O'Connor , Eugene Dantsker , Marci Pezzuto
Inventor： Stephen D. O'Connor , Eugene Dantsker , Marci Pezzuto
IPC: F15C100
CPC classification number: B01L3/502738 , B01L3/502746 , B01L2200/0605 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/0688 , F15C1/02 , F15D1/02 , F16K99/0001 , F16K99/0017 , F16K99/0028 , F16K99/0049 , F16K99/0055 , F16K99/0057 , F16K2099/008 , Y10T137/0491 , Y10T137/2191 , Y10T137/2224 , Y10T137/598 , Y10T137/8242 , Y10T137/86035
Abstract: The invention provides microfluidic devices with embedded fluidic impedances. Such impedances do not allow fluid to pass at a low differential pressure, but allow fluid to flow at a higher differential pressure. Impedances are formed by the three dimensional overlap of two or more channels contained within layers of the device. Such devices can be rapidly protyped and can be assembled to contain multiple fluidic impedances to perform complex fluid handling tasks, including metering defined volumes of samples and dividing samples into aliquots.
Abstract translation: 本发明提供具有嵌入式流体阻抗的微流体装置。 这种阻抗不允许流体在低压差下通过，而是允许流体在较高的压差下流动。 通过包含在器件的层内的两个或更多个沟道的三维重叠形成阻抗。 这样的装置可以快速制成并且可以被组装成包含多个流体阻抗以执行复杂的流体处理任务，包括计量定义的体积的样品并将样品分成等分试样。
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公开(公告)号：US06481453B1
公开(公告)日：2002-11-19
申请号：US10185860
申请日：2002-06-27
Applicant: Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Eugene Dantsker
Inventor： Stephen D. O'Connor , Christoph D. Karp , Marci Pezzuto , Eugene Dantsker
IPC: F17D300
CPC classification number: B01L3/0241 , B01J2219/00315 , B01L3/502784 , B01L2200/0605 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , C40B60/14 , F15C1/02 , F15D1/02 , F16K99/0001 , F16K99/0025 , F16K99/0028 , F16K99/0057 , F16K2099/0074 , F16K2099/008 , G01N35/08 , Y10T137/0419 , Y10T137/0491 , Y10T137/2224 , Y10T137/4259 , Y10T137/85938
Abstract: Microfluidic devices and methods for metering discrete plugs of fluid are provided. The microfluidic devices include a trunk channel and a branch channel having an impedance region. A fluid is supplied to the trunk channel and fills the branch channel to the impedance region. The fluid is then flushed from the trunk channel leaving the branch channel filled. Because the branch channel has a volume, a discrete plug of the fluid having a volume substantially equal to that of the branch channel is formed.
Abstract translation: 提供用于计量流体分离塞的微流体装置和方法。 微流体装置包括干线通道和具有阻抗区域的支路通道。 将流体供应到主干通道并将分支通道填充到阻抗区域。 然后将流体从干线通道冲洗，离开分支通道。 由于分支通道具有体积，因此形成具有基本上等于分支通道的体积的流体的离散塞。
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公开(公告)号：US06848462B2
公开(公告)日：2005-02-01
申请号：US10313231
申请日：2002-12-06
Applicant: Joseph F. Covington , Steven E. Hobbs , Jeffrey A. Koehler , Paren P. Patel , Marci Pezzuto , Mark S. Scheib
Inventor： Joseph F. Covington , Steven E. Hobbs , Jeffrey A. Koehler , Paren P. Patel , Marci Pezzuto , Mark S. Scheib
CPC classification number: B01L3/502707 , B01J2219/00783 , B01J2219/00833 , B01J2219/00835 , B01J2219/00891 , B01J2219/00952 , B01L3/502738 , B01L3/502746 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0681 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B29C65/18 , B29C66/02 , B29C66/026 , B29C66/1122 , B29C66/45 , B29C66/71 , B29C66/727 , B29C66/73112 , B29C66/8322 , B29C66/91212 , B29C66/91213 , B29C66/91216 , B29C66/91221 , B29C66/91231 , B29C66/91411 , B29C66/91445 , B29C66/91645 , B29C66/92445 , B29C66/929 , B29C66/961 , B29K2023/00 , B29K2023/12 , B29L2031/756 , B32B37/0023 , B32B37/08 , B32B37/10 , B32B38/004 , B32B41/00 , B32B2037/0092 , B32B2038/166 , B32B2309/02 , B32B2309/022 , B32B2309/12 , B32B2310/024 , B81B2201/058 , B81C1/00119 , B81C3/008 , B81C2201/019 , G01N27/44791 , G01N30/6095 , Y10T29/49002 , Y10T137/0402 , Y10T137/2224 , Y10T137/598 , B29C2035/0827 , B29K2067/00
Abstract: A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device layers, the device layers including a first cover layer, second cover layer, and at least one stencil layer defining a microfluidic channel penetrating through the entire thickness of the stencil layer also are provided. Each stencil layer is disposed between other device layers such that the channel is bounded laterally by a stencil layer, and bounded from above and below by surrounding device layers to define an upper channel surface and a lower channel surface. The device layers are stacked between the first platen and the second platen. The stacked device layers are controllably heated according to a heating profile adapted to form a substantially sealed adhesiveless microfluidic device wherein each upper channel surface remains distinct from its corresponding lower channel surface. The resulting microfluidic device has high inter-layer bond strength while preserving the integrity of the channel(s) defined in the stencil layer(s).
Abstract translation: 一种制造微流体装置的方法，其中设置有第一和第二基本平坦的压板。 还提供了多个基本平坦的，基本上无金属的无粘合剂聚合物器件层，所述器件层包括第一覆盖层，第二覆盖层和限定穿透模板层的整个厚度的微流体通道的至少一个模板层。 每个模版层设置在其它装置层之间，使得通道被模板层横向限定，并且由周围装置层从上方和下方界定，以限定上通道表面和下通道表面。 装置层堆叠在第一压板和第二压板之间。 根据适于形成基本上密封的无粘合微流体装置的加热轮廓可控制地加热堆叠的装置层，其中每个上部通道表面保持与其相应的下部通道表面不同。 所得到的微流体装置具有高的层间结合强度，同时保持在模版层中定义的通道的完整性。
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公开(公告)号：US06748978B2
公开(公告)日：2004-06-15
申请号：US10188285
申请日：2002-07-01
Applicant: Marci Pezzuto , Stephen D. O'Connor
Inventor： Marci Pezzuto , Stephen D. O'Connor
IPC: F16K2700
CPC classification number: F16K99/0025 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0418 , B01L2400/0487 , B01L2400/0688 , B01L2400/084 , F16K99/0001 , F16K99/0028 , F16K99/0036 , F16K99/0057 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , Y10T137/0318 , Y10T137/206 , Y10T137/2196 , Y10T137/2224
Abstract: Microfluidic devices having porous materials that restrict fluid flow rate for a given pressure are provided. Multiple porous regions can be constructed in a single device so that they have different valving capabilities or impedances, and in unison can control the overall direction of fluid flow. Porous regions can be constructed in various ways, such as, for example: by inserting porous materials into or between channels; by sandwiching one or more sheets or layers of porous materials between other layers of a device; or by inserting a liquid, solution, slurry, or suspension into a microfluidic channel and then permitting the formation of porous deposits by promoting at least partial evaporation. Adhesive tape may be used for one or more layers of such a microfluidic device.
Abstract translation: 提供了具有限制给定压力的流体流速的多孔材料的微流体装置。 可以在单个装置中构造多个多孔区域，使得它们具有不同的阀门能力或阻抗，并且一致地可以控制流体流动的总体方向。 多孔区域可以以各种方式构造，例如：通过将多孔材料插入通道内或通道之间; 通过在设备的其他层之间夹住一个或多个多孔材料层; 或通过将液体，溶液，浆液或悬浮液插入微流体通道中，然后通过促进至少部分蒸发来允许形成多孔沉积物。 胶带可用于这种微流体装置的一层或多层。
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公开(公告)号：US06536477B1
公开(公告)日：2003-03-25
申请号：US09689568
申请日：2000-10-12
Applicant: Stephen D. O'Connor , Eugene Dantsker , Christoph D. Karp , Marci Pezzuto
Inventor： Stephen D. O'Connor , Eugene Dantsker , Christoph D. Karp , Marci Pezzuto
IPC: F15C106
CPC classification number: B01L3/5027 , B01L3/502707 , B01L2200/027 , B01L2300/0887 , B01L2400/0487 , G01N35/10 , G01N2035/00326 , Y10T137/2224
Abstract: Microfluidic coupling devices capable of connecting more than one microfluidic module together to form a larger, integrated system are described. These devices are constructed in a number of ways. In a certain embodiments, the coupler is constructed from laminated materials and mates to one or more microfluidic devices using adhesive. The device can be used to place fluid into a microfluidic device, to remove fluid from a microfluidic device, or to transfer fluid between two or more microfluidic devices. Also described are modular microfluidic systems formed from microfluidic modules made using various techniques and/or useful for performing various functions.
Abstract translation: 描述了能够将多于一个微流体模块连接在一起以形成较大的集成系统的微流体耦合装置。 这些设备以多种方式构建。 在某些实施例中，耦合器由层压材料构成，并使用粘合剂与一个或多个微流体装置配合。 该装置可以用于将流体放入微流体装置中，以从微流体装置中移除流体，或者在两个或多个微流体装置之间传送流体。 还描述了由使用各种技术制造的微流体模块和/或用于执行各种功能而形成的模块化微流体系统。
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